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- W3122865612 endingPage "249" @default.
- W3122865612 startingPage "249" @default.
- W3122865612 abstract "Fuels and polymer precursors are widely used in daily life and in many industrial processes. Although these compounds are mainly derived from petrol, bacteria and yeast can produce them in an environment-friendly way. However, these molecules exhibit toxic solvent properties and reduce cell viability of the microbial producer which inevitably impedes high product titers. Hence, studying how product accumulation affects microbes and understanding how microbial adaptive responses counteract these harmful defects helps to maximize yields. Here, we specifically focus on the mode of toxicity of industry-relevant alcohols, terpenoids and aromatics and the associated stress-response mechanisms, encountered in several relevant bacterial and yeast producers. In practice, integrating heterologous defense mechanisms, overexpressing native stress responses or triggering multiple protection pathways by modifying the transcription machinery or small RNAs (sRNAs) are suitable strategies to improve solvent tolerance. Therefore, tolerance engineering, in combination with metabolic pathway optimization, shows high potential in developing superior microbial producers." @default.
- W3122865612 created "2021-02-01" @default.
- W3122865612 creator A5005685888 @default.
- W3122865612 creator A5063661741 @default.
- W3122865612 creator A5070523413 @default.
- W3122865612 date "2021-01-26" @default.
- W3122865612 modified "2023-10-16" @default.
- W3122865612 title "Increasing Solvent Tolerance to Improve Microbial Production of Alcohols, Terpenoids and Aromatics" @default.
- W3122865612 cites W105510237 @default.
- W3122865612 cites W1509303949 @default.
- W3122865612 cites W1537686192 @default.
- W3122865612 cites W1547518044 @default.
- W3122865612 cites W1552363140 @default.
- W3122865612 cites W1560754586 @default.
- W3122865612 cites W1562983831 @default.
- W3122865612 cites W1568352657 @default.
- W3122865612 cites W1584272432 @default.
- W3122865612 cites W1587535910 @default.
- W3122865612 cites W1594105132 @default.
- W3122865612 cites W1598282860 @default.
- W3122865612 cites W1619751945 @default.
- W3122865612 cites W1716662773 @default.
- W3122865612 cites W1790041928 @default.
- W3122865612 cites W1800420706 @default.
- W3122865612 cites W1830293097 @default.
- W3122865612 cites W1838599396 @default.
- W3122865612 cites W1861537611 @default.
- W3122865612 cites W1910622708 @default.
- W3122865612 cites W1935525973 @default.
- W3122865612 cites W1957671946 @default.
- W3122865612 cites W1965701199 @default.
- W3122865612 cites W1967901576 @default.
- W3122865612 cites W1969369875 @default.
- W3122865612 cites W1972665652 @default.
- W3122865612 cites W1974105595 @default.
- W3122865612 cites W1976081665 @default.
- W3122865612 cites W1978119727 @default.
- W3122865612 cites W1978763680 @default.
- W3122865612 cites W1979579263 @default.
- W3122865612 cites W1980671188 @default.
- W3122865612 cites W1982007024 @default.
- W3122865612 cites W1982033158 @default.
- W3122865612 cites W1982529605 @default.
- W3122865612 cites W1983919727 @default.
- W3122865612 cites W1985279295 @default.
- W3122865612 cites W1988533902 @default.
- W3122865612 cites W1989044894 @default.
- W3122865612 cites W1989148233 @default.
- W3122865612 cites W1991812438 @default.
- W3122865612 cites W1993447713 @default.
- W3122865612 cites W1996276569 @default.
- W3122865612 cites W2002106103 @default.
- W3122865612 cites W2002633990 @default.
- W3122865612 cites W2004696942 @default.
- W3122865612 cites W2004964848 @default.
- W3122865612 cites W2007493979 @default.
- W3122865612 cites W2007632865 @default.
- W3122865612 cites W2008054896 @default.
- W3122865612 cites W2014930721 @default.
- W3122865612 cites W2015389826 @default.
- W3122865612 cites W2016581182 @default.
- W3122865612 cites W2016707038 @default.
- W3122865612 cites W2018341352 @default.
- W3122865612 cites W2021247483 @default.
- W3122865612 cites W2021821426 @default.
- W3122865612 cites W2024105674 @default.
- W3122865612 cites W2030816046 @default.
- W3122865612 cites W2031189086 @default.
- W3122865612 cites W2031315147 @default.
- W3122865612 cites W2032756932 @default.
- W3122865612 cites W2034342274 @default.
- W3122865612 cites W2034395286 @default.
- W3122865612 cites W2034651317 @default.
- W3122865612 cites W2037060512 @default.
- W3122865612 cites W2043105926 @default.
- W3122865612 cites W2043227293 @default.
- W3122865612 cites W2043347989 @default.
- W3122865612 cites W2048031766 @default.
- W3122865612 cites W2050313567 @default.
- W3122865612 cites W2054114849 @default.
- W3122865612 cites W2054351525 @default.
- W3122865612 cites W2058874301 @default.
- W3122865612 cites W2059685673 @default.
- W3122865612 cites W2061233851 @default.
- W3122865612 cites W2062815225 @default.
- W3122865612 cites W2065185864 @default.
- W3122865612 cites W2065554170 @default.
- W3122865612 cites W2066820591 @default.
- W3122865612 cites W2068951440 @default.
- W3122865612 cites W2069331876 @default.
- W3122865612 cites W2071382270 @default.
- W3122865612 cites W2071515363 @default.
- W3122865612 cites W2072563246 @default.
- W3122865612 cites W2072607401 @default.
- W3122865612 cites W2074910098 @default.
- W3122865612 cites W2075937910 @default.
- W3122865612 cites W2076643532 @default.
- W3122865612 cites W2077153252 @default.