Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122877795> ?p ?o ?g. }
- W3122877795 endingPage "2775" @default.
- W3122877795 startingPage "2767" @default.
- W3122877795 abstract "Clinical tissue specimens are often unscreened, and preparation of tissue sections for analysis by mass spectrometry imaging (MSI) can cause aerosolization of particles potentially carrying an infectious load. We here present a decontamination approach based on ultraviolet-C (UV-C) light to inactivate clinically relevant pathogens such as herpesviridae, papovaviridae human immunodeficiency virus, or SARS-CoV-2, which may be present in human tissue samples while preserving the biodistributions of analytes within the tissue. High doses of UV-C required for high-level disinfection were found to cause oxidation and photodegradation of endogenous species. Lower UV-C doses maintaining inactivation of clinically relevant pathogens to a level of increased operator safety were found to be less destructive to the tissue metabolome and xenobiotics. These doses caused less alterations of the tissue metabolome and allowed elucidation of the biodistribution of the endogenous metabolites. Additionally, we were able to determine the spatially integrated abundances of the ATR inhibitor ceralasertib from decontaminated human biopsies using desorption electrospray ionization-MSI (DESI-MSI)." @default.
- W3122877795 created "2021-02-01" @default.
- W3122877795 creator A5017746011 @default.
- W3122877795 creator A5018264411 @default.
- W3122877795 creator A5022677387 @default.
- W3122877795 creator A5024327032 @default.
- W3122877795 creator A5030674018 @default.
- W3122877795 creator A5034863210 @default.
- W3122877795 creator A5044054725 @default.
- W3122877795 creator A5048603885 @default.
- W3122877795 creator A5071775024 @default.
- W3122877795 creator A5072726875 @default.
- W3122877795 creator A5082781519 @default.
- W3122877795 creator A5084595261 @default.
- W3122877795 creator A5087922615 @default.
- W3122877795 date "2021-01-21" @default.
- W3122877795 modified "2023-10-16" @default.
- W3122877795 title "Evaluation of UV-C Decontamination of Clinical Tissue Sections for Spatially Resolved Analysis by Mass Spectrometry Imaging (MSI)" @default.
- W3122877795 cites W1511840405 @default.
- W3122877795 cites W161629070 @default.
- W3122877795 cites W1806180438 @default.
- W3122877795 cites W1864071247 @default.
- W3122877795 cites W1954015493 @default.
- W3122877795 cites W1974737166 @default.
- W3122877795 cites W1976284410 @default.
- W3122877795 cites W1978994862 @default.
- W3122877795 cites W1998709951 @default.
- W3122877795 cites W2009149639 @default.
- W3122877795 cites W2010282107 @default.
- W3122877795 cites W2029872683 @default.
- W3122877795 cites W2038262883 @default.
- W3122877795 cites W2059455136 @default.
- W3122877795 cites W2062723387 @default.
- W3122877795 cites W2069701412 @default.
- W3122877795 cites W2081732518 @default.
- W3122877795 cites W2084088015 @default.
- W3122877795 cites W2114813165 @default.
- W3122877795 cites W2138779768 @default.
- W3122877795 cites W2141274038 @default.
- W3122877795 cites W2162304368 @default.
- W3122877795 cites W2314667906 @default.
- W3122877795 cites W2406121736 @default.
- W3122877795 cites W2520784563 @default.
- W3122877795 cites W2551569138 @default.
- W3122877795 cites W2565155642 @default.
- W3122877795 cites W2586644082 @default.
- W3122877795 cites W2593494645 @default.
- W3122877795 cites W2766212494 @default.
- W3122877795 cites W2766851522 @default.
- W3122877795 cites W2801412012 @default.
- W3122877795 cites W2888118889 @default.
- W3122877795 cites W2897726163 @default.
- W3122877795 cites W2962527362 @default.
- W3122877795 cites W2964307052 @default.
- W3122877795 cites W3033085083 @default.
- W3122877795 cites W3048518429 @default.
- W3122877795 cites W4253918582 @default.
- W3122877795 cites W2010004076 @default.
- W3122877795 cites W3034266002 @default.
- W3122877795 doi "https://doi.org/10.1021/acs.analchem.0c03430" @default.
- W3122877795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33474935" @default.
- W3122877795 hasPublicationYear "2021" @default.
- W3122877795 type Work @default.
- W3122877795 sameAs 3122877795 @default.
- W3122877795 citedByCount "2" @default.
- W3122877795 countsByYear W31228777952021 @default.
- W3122877795 countsByYear W31228777952022 @default.
- W3122877795 crossrefType "journal-article" @default.
- W3122877795 hasAuthorship W3122877795A5017746011 @default.
- W3122877795 hasAuthorship W3122877795A5018264411 @default.
- W3122877795 hasAuthorship W3122877795A5022677387 @default.
- W3122877795 hasAuthorship W3122877795A5024327032 @default.
- W3122877795 hasAuthorship W3122877795A5030674018 @default.
- W3122877795 hasAuthorship W3122877795A5034863210 @default.
- W3122877795 hasAuthorship W3122877795A5044054725 @default.
- W3122877795 hasAuthorship W3122877795A5048603885 @default.
- W3122877795 hasAuthorship W3122877795A5071775024 @default.
- W3122877795 hasAuthorship W3122877795A5072726875 @default.
- W3122877795 hasAuthorship W3122877795A5082781519 @default.
- W3122877795 hasAuthorship W3122877795A5084595261 @default.
- W3122877795 hasAuthorship W3122877795A5087922615 @default.
- W3122877795 hasConcept C107211472 @default.
- W3122877795 hasConcept C121332964 @default.
- W3122877795 hasConcept C162356407 @default.
- W3122877795 hasConcept C177322064 @default.
- W3122877795 hasConcept C185544564 @default.
- W3122877795 hasConcept C185592680 @default.
- W3122877795 hasConcept C24066741 @default.
- W3122877795 hasConcept C43617362 @default.
- W3122877795 hasConceptScore W3122877795C107211472 @default.
- W3122877795 hasConceptScore W3122877795C121332964 @default.
- W3122877795 hasConceptScore W3122877795C162356407 @default.
- W3122877795 hasConceptScore W3122877795C177322064 @default.
- W3122877795 hasConceptScore W3122877795C185544564 @default.
- W3122877795 hasConceptScore W3122877795C185592680 @default.
- W3122877795 hasConceptScore W3122877795C24066741 @default.
- W3122877795 hasConceptScore W3122877795C43617362 @default.
- W3122877795 hasFunder F4320319985 @default.