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- W3122940401 abstract "Peroxisome proliferator- activated receptors (PPARs) are nuclear receptors and function as transcriptional factors involved in some chronic diseases such as lipid metabolism disorder and cancer, which include PPAR alpha, PPAR beta/delta, PPAR gamma. Among them, PPAR beta/delta has exhibited explicitly proangiogenic effects on physiological and pathological angiogenesis. Angiogenesis has been known as a hallmark of cancer. PPAR beta/delta has been suggested to be involved in the regulation of the angiogenic switch in tumor progression. However, until now, it is still unclear to what extent the expression of PPAR beta/delta in tumor endothelium influences tumor progression and metastasis formation. Thus, we addressed this question using transgenic mice with conditional inducible vascular-endothelium specific PPAR beta/delta overexpression. We also induced syngenic tumors following specific PPAR beta/delta overexpression in endothelial cells. We observed higher tumor neovascularization and enhanced tumor growth and metastasis formation in tumors of animals with vascular-specific PPAR beta/delta overexpression. In order to identify potential downstream molecular targets of PPAR beta/delta in tumor endothelium, we sorted endothelial cells from the tumors and performed RNA sequencing. We identified platelet- derived growth factor B (PDGFB), platelet- derived growth factor receptor beta (PDGFR beta) and the receptor tyrosine kinase KIT (c-KIT) as new PPAR beta/delta dependent molecules by ChIP assay. Thus, we demonstrated that PPAR beta/delta activation, regardless of its action on different cancer cell types, promotes tumor progression and metastasis formation through enhancement of tumor angiogenesis." @default.
- W3122940401 created "2021-02-01" @default.
- W3122940401 creator A5010230635 @default.
- W3122940401 date "2020-09-24" @default.
- W3122940401 modified "2023-09-23" @default.
- W3122940401 title "Impact of Vascular PPAR beta/delta Expression on Tumor Progression and Metastasis Formation" @default.
- W3122940401 hasPublicationYear "2020" @default.
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