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- W3122953246 endingPage "1258" @default.
- W3122953246 startingPage "1258" @default.
- W3122953246 abstract "The use of immune checkpoint inhibitors (ICI) in treating cancer has revolutionized the approach to eradicate cancer cells by reactivating immune responses. However, only a subset of patients benefits from this treatment; the majority remains unresponsive or develops resistance to ICI therapy. Increasing evidence suggests that metabolic machinery in the tumor microenvironment (TME) plays a role in the development of ICI resistance. Within the TME, nutrients and oxygen are scarce, forcing immune cells to undergo metabolic reprogramming to adapt to harsh conditions. Cancer-induced metabolic deregulation in immune cells can attenuate their anti-cancer properties, but can also increase their immunosuppressive properties. Therefore, targeting metabolic pathways of immune cells in the TME may strengthen the efficacy of ICIs and prevent ICI resistance. In this review, we discuss the interactions of immune cells and metabolic alterations in the TME. We also discuss current therapies targeting cellular metabolism in combination with ICIs for the treatment of cancer, and provide possible mechanisms behind the cellular metabolic rewiring that may improve clinical outcomes." @default.
- W3122953246 created "2021-02-01" @default.
- W3122953246 creator A5021453806 @default.
- W3122953246 creator A5027192230 @default.
- W3122953246 creator A5032027015 @default.
- W3122953246 creator A5083374053 @default.
- W3122953246 date "2021-01-27" @default.
- W3122953246 modified "2023-10-10" @default.
- W3122953246 title "Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance" @default.
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