FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122964048> ?p ?o ?g. }

• W3122964048 abstract "Abstract Background Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy required for their survival and proliferation. Deregulation of Wnt/β-catenin signaling pathway induces the metabolism switching and oncogenesis in tumor cells. RING finger protein 115 (RNF115) is an E3 ligase for ubiquitin-mediated degradation. Although the oncogenic functions of RNF115 have been revealed in breast tumor cells, the effect of RNF115 on lung cancer is still not clear. Methods RNF115 expression and its correlation with the features of LUAD patients were analyzed by using public database and our own cohort. The functions of RNF115 in proliferation and energy metabolism in LUAD cells were explored by downregulating or upregulating RNF115 expression. Results We demonstrated that RNF115 was overexpressed in LUAD tissues and its expression was positively correlated with the poor overall survival of LUAD patients. Moreover, RNF115 overexpression inhibited LUAD cell apoptosis and promoted cellular proliferation and metabolism in LUAD cells. On the contrary, RNF115 knockdown displayed reverse effects. Furthermore, the underlying mechanism of the biological function of RNF115 in LUAD was through regulating Wnt/β-catenin pathway via ubiquitination of adenomatous polyposis coli (APC). Conclusion The current study reveals a close association between RNF115 expression and prognostic conditions in LUAD patients and the oncogenic roles of RNF115 in LUAD at the first time. These findings may help establish the foundation for the development of therapeutics strategies and clinical management for lung cancer in future." @default.
• W3122964048 created "2021-02-01" @default.
• W3122964048 creator A5005328001 @default.
• W3122964048 creator A5019685354 @default.
• W3122964048 creator A5027182487 @default.
• W3122964048 creator A5041780459 @default.
• W3122964048 creator A5047399889 @default.
• W3122964048 creator A5051014513 @default.
• W3122964048 creator A5051364496 @default.
• W3122964048 creator A5080733133 @default.
• W3122964048 creator A5083447643 @default.
• W3122964048 date "2021-01-28" @default.
• W3122964048 modified "2023-10-18" @default.
• W3122964048 title "RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination" @default.
• W3122964048 cites W1496388003 @default.
• W3122964048 cites W1525117983 @default.
• W3122964048 cites W1965421709 @default.
• W3122964048 cites W1968820967 @default.
• W3122964048 cites W1983572055 @default.
• W3122964048 cites W1986627314 @default.
• W3122964048 cites W1995493096 @default.
• W3122964048 cites W2006419043 @default.
• W3122964048 cites W2022126275 @default.
• W3122964048 cites W2022376508 @default.
• W3122964048 cites W2053417127 @default.
• W3122964048 cites W2064027874 @default.
• W3122964048 cites W2083832226 @default.
• W3122964048 cites W2091961739 @default.
• W3122964048 cites W2126496132 @default.
• W3122964048 cites W2131530904 @default.
• W3122964048 cites W2134072877 @default.
• W3122964048 cites W2137956088 @default.
• W3122964048 cites W2150123812 @default.
• W3122964048 cites W2157699260 @default.
• W3122964048 cites W2159194061 @default.
• W3122964048 cites W2161080156 @default.
• W3122964048 cites W2214552500 @default.
• W3122964048 cites W2258066491 @default.
• W3122964048 cites W2336359166 @default.
• W3122964048 cites W2466033276 @default.
• W3122964048 cites W2520632143 @default.
• W3122964048 cites W2587048937 @default.
• W3122964048 cites W2591535357 @default.
• W3122964048 cites W2609686605 @default.
• W3122964048 cites W2610193187 @default.
• W3122964048 cites W2771031544 @default.
• W3122964048 cites W2777064013 @default.
• W3122964048 cites W2792896484 @default.
• W3122964048 cites W2809990610 @default.
• W3122964048 cites W2811421851 @default.
• W3122964048 cites W2913890130 @default.
• W3122964048 cites W2950278520 @default.
• W3122964048 cites W2954220199 @default.
• W3122964048 cites W3004380698 @default.
• W3122964048 doi "https://doi.org/10.1186/s40170-021-00243-y" @default.
• W3122964048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7842072" @default.
• W3122964048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33509267" @default.
• W3122964048 hasPublicationYear "2021" @default.
• W3122964048 type Work @default.
• W3122964048 sameAs 3122964048 @default.
• W3122964048 citedByCount "10" @default.
• W3122964048 countsByYear W31229640482022 @default.
• W3122964048 countsByYear W31229640482023 @default.
• W3122964048 crossrefType "journal-article" @default.
• W3122964048 hasAuthorship W3122964048A5005328001 @default.
• W3122964048 hasAuthorship W3122964048A5019685354 @default.
• W3122964048 hasAuthorship W3122964048A5027182487 @default.
• W3122964048 hasAuthorship W3122964048A5041780459 @default.
• W3122964048 hasAuthorship W3122964048A5047399889 @default.
• W3122964048 hasAuthorship W3122964048A5051014513 @default.
• W3122964048 hasAuthorship W3122964048A5051364496 @default.
• W3122964048 hasAuthorship W3122964048A5080733133 @default.
• W3122964048 hasAuthorship W3122964048A5083447643 @default.
• W3122964048 hasBestOaLocation W31229640481 @default.
• W3122964048 hasConcept C104317684 @default.
• W3122964048 hasConcept C121608353 @default.
• W3122964048 hasConcept C126322002 @default.
• W3122964048 hasConcept C134459356 @default.
• W3122964048 hasConcept C137620995 @default.
• W3122964048 hasConcept C173396325 @default.
• W3122964048 hasConcept C190283241 @default.
• W3122964048 hasConcept C25602115 @default.
• W3122964048 hasConcept C2776256026 @default.
• W3122964048 hasConcept C2778237340 @default.
• W3122964048 hasConcept C2781182431 @default.
• W3122964048 hasConcept C502942594 @default.
• W3122964048 hasConcept C526805850 @default.
• W3122964048 hasConcept C54355233 @default.
• W3122964048 hasConcept C55493867 @default.
• W3122964048 hasConcept C555283112 @default.
• W3122964048 hasConcept C62112901 @default.
• W3122964048 hasConcept C62478195 @default.
• W3122964048 hasConcept C71924100 @default.
• W3122964048 hasConcept C86803240 @default.
• W3122964048 hasConcept C95444343 @default.
• W3122964048 hasConceptScore W3122964048C104317684 @default.
• W3122964048 hasConceptScore W3122964048C121608353 @default.
• W3122964048 hasConceptScore W3122964048C126322002 @default.
• W3122964048 hasConceptScore W3122964048C134459356 @default.
• W3122964048 hasConceptScore W3122964048C137620995 @default.

• next