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• W3122980620 abstract "Leachates generated by solid waste dumpsites could be a factor in the development of antibiotic resistance in environmental bacteria. In Nigeria, there is a dearth of information on the contribution of leachates from dumpsite to the ever-increasing trend of antibiotic resistance. A total of 250 cefotaxime-resistant bacteria recovered from dumpsite leachate was screened for extended spectrum β-lactamase (ESBL) production using the double disc synergy test and 41 were ESBL producers. The ESBL producers belonged to four genera and were identified as Escherichia (20), Citrobacter (13) , Enterobacter (6) and Raoultella (2). Antibiotic susceptibility testing was carried out using disk diffusion method, while detection of extended spectrum and AmpC β-lactamase genes was done using Real-Time PCR. All the ESBL- producing bacteria were multidrug resistant, with 100% resistance observed to cefotaxime, cefpodoxime, tetracycline, sulfonamide, ciprofloxacin, ampicillin, ertapenem and imipenem, while 81.6% and 63.1% of the ESBL producers showed resistance to ceftazidime and amoxicillin-clavulanate respectively. bla CTX-M-1 and bla CTX-M-9 groups of CTX-M β-lactamases were detected in 33 (80.5%) of the isolates, while 26 (63.4%) harboured the bla CTX-M-2 , bla CTX-M-8 and bla CTX-M-25 groups. bla TEM was detected in 31 (75.6%) of the ESBL producers, while bla SHV was detected in 13 (31.7%). One isolate ( E. coli AW-32) carried bla CMY-1 gene. None of the isolates carried bla KPC , bla NDM-1 and bla ampC genes, while seven isolates were devoid of any gene. There was co-occurrence of resistance genes in thirty of the isolates. This study has revealed that dumpsite leachates could be important reservoirs of multidrug resistant Enterobacteriaceae harbouring extended spectrum and AmpC β-lactamases genes. • Extended spectrum and AmpC β-lactamase genes were detected in forty-one ESBL producers obtained from dumpsite leachate. • All the ESBL producers were multidrug resistant, showing 100% resistance to seven classes of antibiotics. • CTX-M β-lactamase genes predominated with 33 (80.5%) of isolates possessing the phylogenetic groups of the gene. • bla TEM was detected in 31 (75.6%) of the ESBL producing bacteria, while bla SHV was detected in 13 (31.7%). • One isolate possessed bla CMY-1 gene, an AmpC β-lactamase gene." @default.
• W3122980620 created "2021-02-01" @default.
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• W3122980620 date "2021-06-01" @default.
• W3122980620 modified "2023-10-02" @default.
• W3122980620 title "Dumpsite leachate as a hotspot of multidrug resistant Enterobacteriaceae harbouring extended spectrum and AmpC β-lactamase genes; a case study of Awotan municipal solid waste dumpsite in Southwest Nigeria" @default.
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• W3122980620 doi "https://doi.org/10.1016/j.mgene.2021.100853" @default.
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