Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123065819> ?p ?o ?g. }
- W3123065819 endingPage "1137" @default.
- W3123065819 startingPage "1137" @default.
- W3123065819 abstract "The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be oxidized to 8-oxoguanine (8OG), we investigated the capacity of glycosylases 8-oxoguanine glycosylase (OGG1) and endonuclease VIII-like 1 (Neil1) to excise 8OG from 32R, either in duplex or G-quadruplex (G4) conformation. We found that OGG1 efficiently excised 8OG from oxidized 32R in duplex but not in G4 conformation. By contrast, glycosylase Neil1 showed more activity on the G4 than the duplex conformation. We also found that the excising activity of Neil1 on folded 32R depended on G4 topology. Our data suggest that Neil1, besides being involved in base excision repair pathway (BER), could play a role on KRAS transcription." @default.
- W3123065819 created "2021-02-01" @default.
- W3123065819 creator A5033855806 @default.
- W3123065819 creator A5055386727 @default.
- W3123065819 date "2021-01-24" @default.
- W3123065819 modified "2023-10-02" @default.
- W3123065819 title "Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter" @default.
- W3123065819 cites W1587584894 @default.
- W3123065819 cites W1614551514 @default.
- W3123065819 cites W1949858629 @default.
- W3123065819 cites W1965631364 @default.
- W3123065819 cites W1969524738 @default.
- W3123065819 cites W1997030321 @default.
- W3123065819 cites W2001649834 @default.
- W3123065819 cites W2013499563 @default.
- W3123065819 cites W2014988241 @default.
- W3123065819 cites W2015392958 @default.
- W3123065819 cites W2021711239 @default.
- W3123065819 cites W2034882046 @default.
- W3123065819 cites W2049884513 @default.
- W3123065819 cites W2058792844 @default.
- W3123065819 cites W2066411725 @default.
- W3123065819 cites W2068888525 @default.
- W3123065819 cites W2069269337 @default.
- W3123065819 cites W2074139680 @default.
- W3123065819 cites W2077450957 @default.
- W3123065819 cites W2083695927 @default.
- W3123065819 cites W2085877659 @default.
- W3123065819 cites W2087290238 @default.
- W3123065819 cites W2090219305 @default.
- W3123065819 cites W2092424765 @default.
- W3123065819 cites W2097706483 @default.
- W3123065819 cites W2102246152 @default.
- W3123065819 cites W2110773356 @default.
- W3123065819 cites W2113320982 @default.
- W3123065819 cites W2131189986 @default.
- W3123065819 cites W2137474157 @default.
- W3123065819 cites W2137862511 @default.
- W3123065819 cites W2141603634 @default.
- W3123065819 cites W2154184572 @default.
- W3123065819 cites W2162303525 @default.
- W3123065819 cites W2163663923 @default.
- W3123065819 cites W2220466462 @default.
- W3123065819 cites W2232961728 @default.
- W3123065819 cites W2265921391 @default.
- W3123065819 cites W2409385548 @default.
- W3123065819 cites W2471300702 @default.
- W3123065819 cites W2550564089 @default.
- W3123065819 cites W2551324776 @default.
- W3123065819 cites W2606686841 @default.
- W3123065819 cites W2621220151 @default.
- W3123065819 cites W2621333085 @default.
- W3123065819 cites W2768554905 @default.
- W3123065819 cites W2970761835 @default.
- W3123065819 cites W2982499940 @default.
- W3123065819 cites W2996837009 @default.
- W3123065819 cites W3028359160 @default.
- W3123065819 cites W3081189082 @default.
- W3123065819 cites W3082249859 @default.
- W3123065819 doi "https://doi.org/10.3390/ijms22031137" @default.
- W3123065819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7865940" @default.
- W3123065819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33498912" @default.
- W3123065819 hasPublicationYear "2021" @default.
- W3123065819 type Work @default.
- W3123065819 sameAs 3123065819 @default.
- W3123065819 citedByCount "4" @default.
- W3123065819 countsByYear W31230658192021 @default.
- W3123065819 countsByYear W31230658192023 @default.
- W3123065819 crossrefType "journal-article" @default.
- W3123065819 hasAuthorship W3123065819A5033855806 @default.
- W3123065819 hasAuthorship W3123065819A5055386727 @default.
- W3123065819 hasBestOaLocation W31230658191 @default.
- W3123065819 hasConcept C104317684 @default.
- W3123065819 hasConcept C134935766 @default.
- W3123065819 hasConcept C138885662 @default.
- W3123065819 hasConcept C153911025 @default.
- W3123065819 hasConcept C179926584 @default.
- W3123065819 hasConcept C185592680 @default.
- W3123065819 hasConcept C187206112 @default.
- W3123065819 hasConcept C192396546 @default.
- W3123065819 hasConcept C2778301229 @default.
- W3123065819 hasConcept C2781187634 @default.
- W3123065819 hasConcept C41895202 @default.
- W3123065819 hasConcept C501734568 @default.
- W3123065819 hasConcept C512185932 @default.
- W3123065819 hasConcept C552990157 @default.
- W3123065819 hasConcept C55493867 @default.
- W3123065819 hasConcept C86803240 @default.
- W3123065819 hasConceptScore W3123065819C104317684 @default.
- W3123065819 hasConceptScore W3123065819C134935766 @default.
- W3123065819 hasConceptScore W3123065819C138885662 @default.
- W3123065819 hasConceptScore W3123065819C153911025 @default.
- W3123065819 hasConceptScore W3123065819C179926584 @default.
- W3123065819 hasConceptScore W3123065819C185592680 @default.
- W3123065819 hasConceptScore W3123065819C187206112 @default.
- W3123065819 hasConceptScore W3123065819C192396546 @default.
- W3123065819 hasConceptScore W3123065819C2778301229 @default.
- W3123065819 hasConceptScore W3123065819C2781187634 @default.