Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123102386> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3123102386 abstract "Abstract BackgroundRemote ischemic preconditioning (RIPC) is reported to have early-phase and delayed-phase organ-protective effects. Whether the modified RIPC (mRIPC) protocol performed repeatedly provides cardiopulmonary protection is still uncertain.MethodsIn this single-center, randomized, controlled trial, 86 patients undergoing elective mitral valve replacement (MVR) surgery were randomized 1:1 to receive either mRIPC or no ischemic preconditioning (control). Three cycles of 5 min ischemia and 5 min reperfusion induced by a blood pressure cuff served as the RIPC stimulus. Modified RIPC was induced at the following three time points: 24 h, 12 h and 1 h before surgery. Blood samples were withdrawn at 10 min after intubation (T0), at 1 h after aortic declamping (T1), and at 6 h (T2), 12 h (T3), and 24 h (T4) after surgery to measure the serum concentrations of myocardial enzymes and other biomarkers, including cardiac troponin I (cTnI), which was the primary end point of this study. Creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH), inotropic score (IS) and inflammatory mediators were also measured. Blood gas analysis was conducted to calculate the PaO 2 /FiO 2 ratio and A-aDO 2 , and the incidence of acute lung injury (ALI) was also recorded.ResultsModified RIPC significantly decreased the serum concentrations of cTnI, CK-MB and LDH at T2, T3 and T4 ( P < 0.01), and the IS decreased compared with that in the control group (11.96 ± 0.92 vs. 14.20 ± 1.09, P < 0.01). In addition, the incidence of ALI in the mRIPC group was decreased (18.60% vs. 34.88%, P = 0.046), and the PaO 2 /FiO 2 was higher at T4 ( P < 0.05). Compared with those in the control group, the levels of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) were decreased at T1, T2, T3 and T4 ( P < 0.05) in the mRIPC group, and the level of IL-10 increased at the same time.ConclusionsModified RIPC decreased the incidence of myocardial and lung injury in MVR surgery, providing new evidence for the clinical application of RIPC in valve surgery.Trial registrationThis study was registered in ClinicalTrials.gov (NCT03010839). Date of Registration on November 5th, 2016." @default.
- W3123102386 created "2021-02-01" @default.
- W3123102386 creator A5013161931 @default.
- W3123102386 creator A5016098243 @default.
- W3123102386 creator A5021391037 @default.
- W3123102386 creator A5041076440 @default.
- W3123102386 creator A5046245231 @default.
- W3123102386 creator A5055717526 @default.
- W3123102386 creator A5063868027 @default.
- W3123102386 date "2021-01-25" @default.
- W3123102386 modified "2023-09-26" @default.
- W3123102386 title "Cardiopulmonary protection of modified remote ischemic preconditioning in mitral valve replacement surgery: A randomized controlled trial" @default.
- W3123102386 doi "https://doi.org/10.21203/rs.3.rs-152372/v1" @default.
- W3123102386 hasPublicationYear "2021" @default.
- W3123102386 type Work @default.
- W3123102386 sameAs 3123102386 @default.
- W3123102386 citedByCount "0" @default.
- W3123102386 crossrefType "posted-content" @default.
- W3123102386 hasAuthorship W3123102386A5013161931 @default.
- W3123102386 hasAuthorship W3123102386A5016098243 @default.
- W3123102386 hasAuthorship W3123102386A5021391037 @default.
- W3123102386 hasAuthorship W3123102386A5041076440 @default.
- W3123102386 hasAuthorship W3123102386A5046245231 @default.
- W3123102386 hasAuthorship W3123102386A5055717526 @default.
- W3123102386 hasAuthorship W3123102386A5063868027 @default.
- W3123102386 hasBestOaLocation W31231023861 @default.
- W3123102386 hasConcept C115725540 @default.
- W3123102386 hasConcept C126322002 @default.
- W3123102386 hasConcept C141071460 @default.
- W3123102386 hasConcept C164705383 @default.
- W3123102386 hasConcept C168563851 @default.
- W3123102386 hasConcept C2775854548 @default.
- W3123102386 hasConcept C2777543888 @default.
- W3123102386 hasConcept C2778881276 @default.
- W3123102386 hasConcept C2779311647 @default.
- W3123102386 hasConcept C2780017030 @default.
- W3123102386 hasConcept C36880943 @default.
- W3123102386 hasConcept C42219234 @default.
- W3123102386 hasConcept C500558357 @default.
- W3123102386 hasConcept C541997718 @default.
- W3123102386 hasConcept C71924100 @default.
- W3123102386 hasConceptScore W3123102386C115725540 @default.
- W3123102386 hasConceptScore W3123102386C126322002 @default.
- W3123102386 hasConceptScore W3123102386C141071460 @default.
- W3123102386 hasConceptScore W3123102386C164705383 @default.
- W3123102386 hasConceptScore W3123102386C168563851 @default.
- W3123102386 hasConceptScore W3123102386C2775854548 @default.
- W3123102386 hasConceptScore W3123102386C2777543888 @default.
- W3123102386 hasConceptScore W3123102386C2778881276 @default.
- W3123102386 hasConceptScore W3123102386C2779311647 @default.
- W3123102386 hasConceptScore W3123102386C2780017030 @default.
- W3123102386 hasConceptScore W3123102386C36880943 @default.
- W3123102386 hasConceptScore W3123102386C42219234 @default.
- W3123102386 hasConceptScore W3123102386C500558357 @default.
- W3123102386 hasConceptScore W3123102386C541997718 @default.
- W3123102386 hasConceptScore W3123102386C71924100 @default.
- W3123102386 hasLocation W31231023861 @default.
- W3123102386 hasOpenAccess W3123102386 @default.
- W3123102386 hasPrimaryLocation W31231023861 @default.
- W3123102386 hasRelatedWork W113658129 @default.
- W3123102386 hasRelatedWork W2009163517 @default.
- W3123102386 hasRelatedWork W2038291507 @default.
- W3123102386 hasRelatedWork W2062502632 @default.
- W3123102386 hasRelatedWork W2144581139 @default.
- W3123102386 hasRelatedWork W2375016267 @default.
- W3123102386 hasRelatedWork W2438379726 @default.
- W3123102386 hasRelatedWork W2540999893 @default.
- W3123102386 hasRelatedWork W2886452148 @default.
- W3123102386 hasRelatedWork W3028675807 @default.
- W3123102386 isParatext "false" @default.
- W3123102386 isRetracted "false" @default.
- W3123102386 magId "3123102386" @default.
- W3123102386 workType "article" @default.