FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123169737> ?p ?o ?g. }

• W3123169737 abstract "Gut bacterial dysbiosis plays a vital role in the development of Alzheimer’s disease (AD). However, our understanding of alterations to the gut fungal microbiota and their correlations with host immunity in AD is still limited. Samples were obtained from 88 Chinese patients with AD, and 65 age- and gender-matched, cognitively normal controls. Using these samples, we investigated the fungal microbiota targeting internal transcribed spacer 2 (ITS2) rRNA genes using MiSeq sequencing, and analyzed their associations with the host immune response. Our data demonstrated unaltered fungal diversity but altered taxonomic composition of the fecal fungal microbiota in the AD patients. The analysis of the fungal microbiota was performed using 6,585,557 high-quality reads (2,932,482 reads from the controls and 3,653,075 from the AD patients), with an average of 43,042 reads per sample. We found that several key differential fungi such as Candida tropicalis and Schizophyllum commune were enriched in the AD patients, while Rhodotorula mucilaginosa decreased significantly. Interestingly, C. tropicalis and S. commune were positively correlated with IP-10 and TNF-α levels. In contrast, C. tropicalis was negatively correlated with IL-8 and IFN-γ levels, and R. mucilaginosa was negatively correlated with TNF-α level. PiCRUSt analysis revealed that lipoic acid metabolism, starch and sucrose metabolism were significantly decreased in the AD fungal microbiota. This study is the first to demonstrate fecal fungal dysbiosis in stable AD patients at a deeper level, and to identify the key differential fungi involved in regulating host systemic immunity. The analysis of the fungal microbiota in AD performed here may provide novel insights into the etiopathogenesis of AD and pave the way for improved diagnosis and treatment of AD." @default.
• W3123169737 created "2021-02-01" @default.
• W3123169737 creator A5001542595 @default.
• W3123169737 creator A5003094236 @default.
• W3123169737 creator A5008881593 @default.
• W3123169737 creator A5024113299 @default.
• W3123169737 creator A5034266315 @default.
• W3123169737 creator A5034351574 @default.
• W3123169737 creator A5037491881 @default.
• W3123169737 creator A5043364506 @default.
• W3123169737 date "2021-01-28" @default.
• W3123169737 modified "2023-10-18" @default.
• W3123169737 title "Fecal Fungal Dysbiosis in Chinese Patients With Alzheimer’s Disease" @default.
• W3123169737 cites W1602771322 @default.
• W3123169737 cites W1966689073 @default.
• W3123169737 cites W1974423650 @default.
• W3123169737 cites W1984420823 @default.
• W3123169737 cites W1992670283 @default.
• W3123169737 cites W2032066134 @default.
• W3123169737 cites W2038835308 @default.
• W3123169737 cites W2061177996 @default.
• W3123169737 cites W2072970694 @default.
• W3123169737 cites W2074589102 @default.
• W3123169737 cites W2108718991 @default.
• W3123169737 cites W2110300022 @default.
• W3123169737 cites W2122320288 @default.
• W3123169737 cites W2124351063 @default.
• W3123169737 cites W2133856765 @default.
• W3123169737 cites W2136879569 @default.
• W3123169737 cites W2139911439 @default.
• W3123169737 cites W2153109441 @default.
• W3123169737 cites W2154026962 @default.
• W3123169737 cites W2169767586 @default.
• W3123169737 cites W2170024099 @default.
• W3123169737 cites W2260815707 @default.
• W3123169737 cites W2396765784 @default.
• W3123169737 cites W2522491625 @default.
• W3123169737 cites W2586897522 @default.
• W3123169737 cites W2606594686 @default.
• W3123169737 cites W2616380171 @default.
• W3123169737 cites W2623108751 @default.
• W3123169737 cites W2736839127 @default.
• W3123169737 cites W2761210275 @default.
• W3123169737 cites W2769232178 @default.
• W3123169737 cites W2769906121 @default.
• W3123169737 cites W2783354803 @default.
• W3123169737 cites W2787612390 @default.
• W3123169737 cites W2794632074 @default.
• W3123169737 cites W2799884346 @default.
• W3123169737 cites W2889787710 @default.
• W3123169737 cites W2896535333 @default.
• W3123169737 cites W2903428492 @default.
• W3123169737 cites W2910417977 @default.
• W3123169737 cites W2910852289 @default.
• W3123169737 cites W2915525319 @default.
• W3123169737 cites W2920086083 @default.
• W3123169737 cites W2921154038 @default.
• W3123169737 cites W2937834684 @default.
• W3123169737 cites W2944415973 @default.
• W3123169737 cites W2952005092 @default.
• W3123169737 cites W2965398438 @default.
• W3123169737 cites W2967674535 @default.
• W3123169737 cites W2972007077 @default.
• W3123169737 cites W2978789909 @default.
• W3123169737 cites W2996654920 @default.
• W3123169737 cites W3014134161 @default.
• W3123169737 cites W3022918459 @default.
• W3123169737 cites W30236741 @default.
• W3123169737 cites W3027618338 @default.
• W3123169737 cites W3043048574 @default.
• W3123169737 cites W3044030235 @default.
• W3123169737 cites W3094552086 @default.
• W3123169737 cites W3095092551 @default.
• W3123169737 cites W3096059903 @default.
• W3123169737 cites W3096426693 @default.
• W3123169737 cites W3097657279 @default.
• W3123169737 cites W3099178832 @default.
• W3123169737 cites W3109631583 @default.
• W3123169737 cites W3109920867 @default.
• W3123169737 cites W3112945626 @default.
• W3123169737 cites W3112984078 @default.
• W3123169737 cites W4210987525 @default.
• W3123169737 cites W4211139529 @default.
• W3123169737 cites W4211213171 @default.
• W3123169737 cites W4233559841 @default.
• W3123169737 doi "https://doi.org/10.3389/fcell.2020.631460" @default.
• W3123169737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7876328" @default.
• W3123169737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33585471" @default.
• W3123169737 hasPublicationYear "2021" @default.
• W3123169737 type Work @default.
• W3123169737 sameAs 3123169737 @default.
• W3123169737 citedByCount "18" @default.
• W3123169737 countsByYear W31231697372021 @default.
• W3123169737 countsByYear W31231697372022 @default.
• W3123169737 countsByYear W31231697372023 @default.
• W3123169737 crossrefType "journal-article" @default.
• W3123169737 hasAuthorship W3123169737A5001542595 @default.
• W3123169737 hasAuthorship W3123169737A5003094236 @default.
• W3123169737 hasAuthorship W3123169737A5008881593 @default.
• W3123169737 hasAuthorship W3123169737A5024113299 @default.

• next