Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123178860> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W3123178860 abstract "The present study aims to evaluate the ability of peonidin and petunidin-3-glucoside (Peo and Pet-3-glc) and their metabolites (vanillic acid; VA and methyl-gallic acid; MetGA), to prevent monocyte (THP-1) adhesion to endothelial cells (HUVECs), and to reduce the production of VCAM-1, E-selectin and VEGF in a stimulated pro-inflammatory environment, a pivotal step of atherogenesis. Tumor necrosis factor-α (TNF-α; 100 ng mL-1) was used to stimulate the adhesion of labelled monocytes (THP-1) to endothelial cells (HUVECs). Successively, different concentrations of Peo-3-glc and Pet-3-glc (0.02, 0.2, 2 and 20 µM) and VA and MetGA (0.05, 0.5, 5 and 50 µM) were tested. After 24 h, the production of VCAM-1, E-selectin and VEGF was quantified by ELISA kits, while the adhesion process was measured spectrophotometrically. Peo-3-glc and Pet-3-glc (from 0.02 to 20 µM) significantly (p<0.0001) decreased THP-1 adhesion to HUVECs at all concentrations (-37%, -24%, -30% and -47% for Peo-3-glc; -37%, -33%, -33% and -45% for Pet-3-glc). VA, but not MetGA, reduced the adhesion process at 50 µM (-21%; p<0.001). At the same concentrations, a significant (p<0.0001) reduction of E-selectin, but not VCAM-1, was documented. In addition, anthocyanins and their metabolites significantly decreased (p<0.001) VEGF production. The present findings suggest, that while Peo-3-glc and Pet-3-glc, but not their metabolites, reduced monocyte adhesion to endothelial cells through suppression of E-selectin production, VEGF production was reduced by both anthocyanins and their metabolites suggesting a role in regulation of angiogenesis." @default.
- W3123178860 created "2021-02-01" @default.
- W3123178860 creator A5020279650 @default.
- W3123178860 creator A5029106366 @default.
- W3123178860 creator A5032835338 @default.
- W3123178860 creator A5038940837 @default.
- W3123178860 creator A5046772605 @default.
- W3123178860 creator A5080535745 @default.
- W3123178860 date "2020-01-11" @default.
- W3123178860 modified "2023-10-18" @default.
- W3123178860 title "Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In-Vitro Model of Atherosclerosis" @default.
- W3123178860 doi "https://doi.org/10.20944/preprints202001.0113.v1" @default.
- W3123178860 hasPublicationYear "2020" @default.
- W3123178860 type Work @default.
- W3123178860 sameAs 3123178860 @default.
- W3123178860 citedByCount "1" @default.
- W3123178860 countsByYear W31231788602021 @default.
- W3123178860 crossrefType "posted-content" @default.
- W3123178860 hasAuthorship W3123178860A5020279650 @default.
- W3123178860 hasAuthorship W3123178860A5029106366 @default.
- W3123178860 hasAuthorship W3123178860A5032835338 @default.
- W3123178860 hasAuthorship W3123178860A5038940837 @default.
- W3123178860 hasAuthorship W3123178860A5046772605 @default.
- W3123178860 hasAuthorship W3123178860A5080535745 @default.
- W3123178860 hasBestOaLocation W31231788601 @default.
- W3123178860 hasConcept C134018914 @default.
- W3123178860 hasConcept C178790620 @default.
- W3123178860 hasConcept C17991360 @default.
- W3123178860 hasConcept C185592680 @default.
- W3123178860 hasConcept C199616788 @default.
- W3123178860 hasConcept C2778004101 @default.
- W3123178860 hasConcept C2778362808 @default.
- W3123178860 hasConcept C55493867 @default.
- W3123178860 hasConcept C71924100 @default.
- W3123178860 hasConcept C84416704 @default.
- W3123178860 hasConcept C85789140 @default.
- W3123178860 hasConceptScore W3123178860C134018914 @default.
- W3123178860 hasConceptScore W3123178860C178790620 @default.
- W3123178860 hasConceptScore W3123178860C17991360 @default.
- W3123178860 hasConceptScore W3123178860C185592680 @default.
- W3123178860 hasConceptScore W3123178860C199616788 @default.
- W3123178860 hasConceptScore W3123178860C2778004101 @default.
- W3123178860 hasConceptScore W3123178860C2778362808 @default.
- W3123178860 hasConceptScore W3123178860C55493867 @default.
- W3123178860 hasConceptScore W3123178860C71924100 @default.
- W3123178860 hasConceptScore W3123178860C84416704 @default.
- W3123178860 hasConceptScore W3123178860C85789140 @default.
- W3123178860 hasLocation W31231788601 @default.
- W3123178860 hasLocation W31231788602 @default.
- W3123178860 hasLocation W31231788603 @default.
- W3123178860 hasOpenAccess W3123178860 @default.
- W3123178860 hasPrimaryLocation W31231788601 @default.
- W3123178860 hasRelatedWork W11835298 @default.
- W3123178860 hasRelatedWork W12877788 @default.
- W3123178860 hasRelatedWork W14201815 @default.
- W3123178860 hasRelatedWork W20434869 @default.
- W3123178860 hasRelatedWork W21710102 @default.
- W3123178860 hasRelatedWork W22326212 @default.
- W3123178860 hasRelatedWork W28180501 @default.
- W3123178860 hasRelatedWork W31989641 @default.
- W3123178860 hasRelatedWork W35043363 @default.
- W3123178860 hasRelatedWork W37075423 @default.
- W3123178860 isParatext "false" @default.
- W3123178860 isRetracted "false" @default.
- W3123178860 magId "3123178860" @default.
- W3123178860 workType "article" @default.