Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123202321> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3123202321 endingPage "105732" @default.
- W3123202321 startingPage "105732" @default.
- W3123202321 abstract "An increasing resistance of human pathogenic bacteria and fungi has become a global health problem. Based on previous reports of 4-(salicylideneamino)benzoic acids, we designed, synthesised and evaluated their me-too analogues as potential antimicrobial agents. Forty imines derived from substituted salicylaldehydes and aminobenzoic acids, 4-aminobenzoic acid esters and 4-amino-N-phenylbenzamide were designed using molecular hybridization and prodrug strategies. The target compounds were synthesized with high yields and characterized by spectral methods. They were investigated against a panel of Gram-positive and Gram-negative bacteria, mycobacteria, yeasts and moulds. The most active imines were tested to determine their cytotoxicity and selectivity in HepG2 cells. Dihalogenosalicylaldehydes-based derivatives showed potent broad-spectrum antimicrobial properties, particularly against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (minimum inhibitory concentrations, MIC, from 7.81 µM) and Enterococcus faecalis (MIC of ≥15.62 µM), yeasts (MIC from 7.81 µM) and Trichophyton interdigitale mould (MIC of ≥3.90 µM). Methyl 4-[(2-hydroxy-3,5-diiodobenzylidene)amino]benzoate 4h exhibited excellent in vitro activity along with low toxicity to mammalian cells. This compound is selective for staphylococci, Candida spp. and Trichophyton interdigitale. In addition, this imine was evaluated as a potential inhibitor of Gram-positive biofilms. The successful approach used provided some promising derivatives with more advantageous properties than the parent 4-(salicylideneamino)benzoic acids." @default.
- W3123202321 created "2021-02-01" @default.
- W3123202321 creator A5018987430 @default.
- W3123202321 creator A5025945176 @default.
- W3123202321 creator A5029955040 @default.
- W3123202321 creator A5031101723 @default.
- W3123202321 creator A5056513778 @default.
- W3123202321 creator A5078611040 @default.
- W3123202321 date "2021-04-01" @default.
- W3123202321 modified "2023-09-24" @default.
- W3123202321 title "Optimizing the structure of (salicylideneamino)benzoic acids: Towards selective antifungal and anti-staphylococcal agents" @default.
- W3123202321 cites W1511878397 @default.
- W3123202321 cites W1988701195 @default.
- W3123202321 cites W2019815534 @default.
- W3123202321 cites W2039742102 @default.
- W3123202321 cites W2048312836 @default.
- W3123202321 cites W2062744755 @default.
- W3123202321 cites W2103063068 @default.
- W3123202321 cites W2116904583 @default.
- W3123202321 cites W2136202414 @default.
- W3123202321 cites W2141563676 @default.
- W3123202321 cites W2154615773 @default.
- W3123202321 cites W2168638566 @default.
- W3123202321 cites W2399827296 @default.
- W3123202321 cites W2518179790 @default.
- W3123202321 cites W2750959598 @default.
- W3123202321 cites W2790695048 @default.
- W3123202321 cites W2888695392 @default.
- W3123202321 cites W2896971423 @default.
- W3123202321 cites W2927270655 @default.
- W3123202321 cites W2948966009 @default.
- W3123202321 cites W2949248133 @default.
- W3123202321 cites W2966641782 @default.
- W3123202321 cites W2966922705 @default.
- W3123202321 cites W2989934952 @default.
- W3123202321 cites W2995372026 @default.
- W3123202321 cites W3009424018 @default.
- W3123202321 cites W3012379779 @default.
- W3123202321 cites W4211178015 @default.
- W3123202321 doi "https://doi.org/10.1016/j.ejps.2021.105732" @default.
- W3123202321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33493669" @default.
- W3123202321 hasPublicationYear "2021" @default.
- W3123202321 type Work @default.
- W3123202321 sameAs 3123202321 @default.
- W3123202321 citedByCount "4" @default.
- W3123202321 countsByYear W31232023212021 @default.
- W3123202321 countsByYear W31232023212023 @default.
- W3123202321 crossrefType "journal-article" @default.
- W3123202321 hasAuthorship W3123202321A5018987430 @default.
- W3123202321 hasAuthorship W3123202321A5025945176 @default.
- W3123202321 hasAuthorship W3123202321A5029955040 @default.
- W3123202321 hasAuthorship W3123202321A5031101723 @default.
- W3123202321 hasAuthorship W3123202321A5056513778 @default.
- W3123202321 hasAuthorship W3123202321A5078611040 @default.
- W3123202321 hasConcept C108215921 @default.
- W3123202321 hasConcept C176947019 @default.
- W3123202321 hasConcept C185592680 @default.
- W3123202321 hasConcept C2778844314 @default.
- W3123202321 hasConcept C2779489039 @default.
- W3123202321 hasConcept C2779895986 @default.
- W3123202321 hasConcept C4937899 @default.
- W3123202321 hasConcept C523546767 @default.
- W3123202321 hasConcept C54355233 @default.
- W3123202321 hasConcept C55493867 @default.
- W3123202321 hasConcept C86803240 @default.
- W3123202321 hasConcept C89423630 @default.
- W3123202321 hasConceptScore W3123202321C108215921 @default.
- W3123202321 hasConceptScore W3123202321C176947019 @default.
- W3123202321 hasConceptScore W3123202321C185592680 @default.
- W3123202321 hasConceptScore W3123202321C2778844314 @default.
- W3123202321 hasConceptScore W3123202321C2779489039 @default.
- W3123202321 hasConceptScore W3123202321C2779895986 @default.
- W3123202321 hasConceptScore W3123202321C4937899 @default.
- W3123202321 hasConceptScore W3123202321C523546767 @default.
- W3123202321 hasConceptScore W3123202321C54355233 @default.
- W3123202321 hasConceptScore W3123202321C55493867 @default.
- W3123202321 hasConceptScore W3123202321C86803240 @default.
- W3123202321 hasConceptScore W3123202321C89423630 @default.
- W3123202321 hasFunder F4320321006 @default.
- W3123202321 hasFunder F4320335322 @default.
- W3123202321 hasLocation W31232023211 @default.
- W3123202321 hasOpenAccess W3123202321 @default.
- W3123202321 hasPrimaryLocation W31232023211 @default.
- W3123202321 hasRelatedWork W1967892852 @default.
- W3123202321 hasRelatedWork W2008512511 @default.
- W3123202321 hasRelatedWork W2514452971 @default.
- W3123202321 hasRelatedWork W2753184995 @default.
- W3123202321 hasRelatedWork W2954159082 @default.
- W3123202321 hasRelatedWork W2964010063 @default.
- W3123202321 hasRelatedWork W3107914937 @default.
- W3123202321 hasRelatedWork W3123202321 @default.
- W3123202321 hasRelatedWork W4280557691 @default.
- W3123202321 hasRelatedWork W4280601032 @default.
- W3123202321 hasVolume "159" @default.
- W3123202321 isParatext "false" @default.
- W3123202321 isRetracted "false" @default.
- W3123202321 magId "3123202321" @default.
- W3123202321 workType "article" @default.