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- W3123240166 endingPage "292" @default.
- W3123240166 startingPage "265" @default.
- W3123240166 abstract "The field of DNA nanotechnology came into existence with the primary aim of building DNA scaffolds that could be used to organize macromolecules with nanometer precision. The programmable Watson–Crick base pairing properties of DNA molecules have been exploited to create branched junctions via sticky-end cohesion, which could be reprogrammed by reciprocal exchange to create new types of junctions. This way, myriad DNA assemblies have been constructed, exploring diversity in size, shape, and complexity. However, until fairly recently, most of these assemblies only exhibited structural properties and lacked dynamic behavior. This limitation was overcome with the development of the toehold-mediated strand displacement reaction, in which a DNA strand can displace another from a DNA assembly by virtue of greater complementarity. The thermodynamic and kinetic properties of such reactions have been extensively studied such that precise control can be exerted over a reaction of interest. In the context of DNA nanotechnology, strand displacement was first utilized to dynamically reconfigure DNA objects between different topological states. It was also used to engineer new systems with evolved functions, such as DNA walkers that mimic the movement of motor proteins along microtubules and can achieve transport and DNA computing devices that are capable of processing information encoded in a DNA sequence to produce a desired response. A particular emphasis is given in this review to DNA computing devices due to their ability to process information at the molecular level, which could be a fundamental feature for attaining advanced functions in biotechnological and biomedical applications." @default.
- W3123240166 created "2021-02-01" @default.
- W3123240166 creator A5032305764 @default.
- W3123240166 creator A5065785380 @default.
- W3123240166 date "2021-01-15" @default.
- W3123240166 modified "2023-09-26" @default.
- W3123240166 title "Strand Displacement in DNA ‐Based Nanodevices and Logic" @default.
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