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- W3123267369 endingPage "2709" @default.
- W3123267369 startingPage "2696" @default.
- W3123267369 abstract "The increased susceptibility of ripe fruit to fungal pathogens poses a substantial threat to crop production and marketability. Here, we coupled transcriptomic analyses with mutant studies to uncover critical processes associated with defense and susceptibility in tomato (Solanum lycopersicum) fruit. Using unripe and ripe fruit inoculated with three fungal pathogens, we identified common pathogen responses reliant on chitinases, WRKY transcription factors, and reactive oxygen species detoxification. We established that the magnitude and diversity of defense responses do not significantly impact the interaction outcome, as susceptible ripe fruit mounted a strong immune response to pathogen infection. Then, to distinguish features of ripening that may be responsible for susceptibility, we utilized non-ripening tomato mutants that displayed different susceptibility patterns to fungal infection. Based on transcriptional and hormone profiling, susceptible tomato genotypes had losses in the maintenance of cellular redox homeostasis, while jasmonic acid accumulation and signaling coincided with defense activation in resistant fruit. We identified and validated a susceptibility factor, pectate lyase (PL). CRISPR-based knockouts of PL, but not polygalacturonase (PG2a), reduced susceptibility of ripe fruit by >50%. This study suggests that targeting specific genes that promote susceptibility is a viable strategy to improve the resistance of tomato fruit against fungal disease." @default.
- W3123267369 created "2021-02-01" @default.
- W3123267369 creator A5001798930 @default.
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- W3123267369 creator A5078512560 @default.
- W3123267369 date "2021-01-19" @default.
- W3123267369 modified "2023-10-16" @default.
- W3123267369 title "Host susceptibility factors render ripe tomato fruit vulnerable to fungal disease despite active immune responses" @default.
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- W3123267369 cites W1958695491 @default.
- W3123267369 cites W1969398747 @default.
- W3123267369 cites W1971588351 @default.
- W3123267369 cites W1972448623 @default.
- W3123267369 cites W1978402038 @default.
- W3123267369 cites W1981615505 @default.
- W3123267369 cites W1982130501 @default.
- W3123267369 cites W1984980713 @default.
- W3123267369 cites W1994953727 @default.
- W3123267369 cites W2001824684 @default.
- W3123267369 cites W2003190329 @default.
- W3123267369 cites W2016613675 @default.
- W3123267369 cites W2031967316 @default.
- W3123267369 cites W2047725454 @default.
- W3123267369 cites W2050018481 @default.
- W3123267369 cites W2050860522 @default.
- W3123267369 cites W2052643756 @default.
- W3123267369 cites W2056837410 @default.
- W3123267369 cites W2058495284 @default.
- W3123267369 cites W2066386162 @default.
- W3123267369 cites W2071752315 @default.
- W3123267369 cites W2072802751 @default.
- W3123267369 cites W2076370029 @default.
- W3123267369 cites W2081055023 @default.
- W3123267369 cites W2089283973 @default.
- W3123267369 cites W2099110887 @default.
- W3123267369 cites W2100441566 @default.
- W3123267369 cites W2102911889 @default.
- W3123267369 cites W2106420560 @default.
- W3123267369 cites W2107060225 @default.
- W3123267369 cites W2107979013 @default.
- W3123267369 cites W2110543362 @default.
- W3123267369 cites W2113005886 @default.
- W3123267369 cites W2116231861 @default.
- W3123267369 cites W2116420468 @default.
- W3123267369 cites W2117818501 @default.
- W3123267369 cites W2123613115 @default.
- W3123267369 cites W2128113924 @default.
- W3123267369 cites W2130442690 @default.
- W3123267369 cites W2131271579 @default.
- W3123267369 cites W2133579817 @default.
- W3123267369 cites W2137875276 @default.
- W3123267369 cites W2148403253 @default.
- W3123267369 cites W2150731830 @default.
- W3123267369 cites W2153733135 @default.
- W3123267369 cites W2156934470 @default.
- W3123267369 cites W2160669366 @default.
- W3123267369 cites W2161397936 @default.
- W3123267369 cites W2163673935 @default.
- W3123267369 cites W2170551349 @default.
- W3123267369 cites W2179438025 @default.
- W3123267369 cites W2296905245 @default.
- W3123267369 cites W2328633258 @default.
- W3123267369 cites W2340395486 @default.
- W3123267369 cites W2415373434 @default.
- W3123267369 cites W2502879233 @default.
- W3123267369 cites W2529592713 @default.
- W3123267369 cites W2570342114 @default.
- W3123267369 cites W2605305085 @default.
- W3123267369 cites W2766581318 @default.
- W3123267369 cites W2789207181 @default.
- W3123267369 cites W2799501975 @default.
- W3123267369 cites W2802886016 @default.
- W3123267369 cites W2884883504 @default.
- W3123267369 cites W2886104993 @default.
- W3123267369 cites W2900619387 @default.
- W3123267369 cites W2901999571 @default.
- W3123267369 cites W2912451059 @default.
- W3123267369 cites W2913973081 @default.
- W3123267369 cites W2914996391 @default.
- W3123267369 cites W2922022650 @default.
- W3123267369 cites W2941451696 @default.
- W3123267369 cites W2966391710 @default.
- W3123267369 cites W2991165410 @default.
- W3123267369 cites W3019648101 @default.
- W3123267369 cites W4211213709 @default.
- W3123267369 doi "https://doi.org/10.1093/jxb/eraa601" @default.
- W3123267369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8006553" @default.
- W3123267369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33462583" @default.
- W3123267369 hasPublicationYear "2021" @default.
- W3123267369 type Work @default.