Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123276546> ?p ?o ?g. }
- W3123276546 endingPage "1080" @default.
- W3123276546 startingPage "1073" @default.
- W3123276546 abstract "Background Achieving the best possible reperfusion is a key determinant of clinical outcome after mechanical thrombectomy (MT). However, data on the safety and efficacy of intra-arterial (IA) fibrinolytics as an adjunct to MT with the intention to improve reperfusion are sparse. Methods We performed a PROSPERO-registered (CRD42020149124) systematic review and meta-analysis accessing MEDLINE, PubMed, and Embase from January 1, 2000 to January 1, 2020. A random-effect estimate (Mantel-Haenszel) was computed and summary OR with 95% CI were used as a measure of added IA fibrinolytics versus control on the risk of symptomatic intracranial hemorrhage (sICH) and secondary endpoints (modified Rankin Scale ≤2, mortality at 90 days). Results The search identified six observational cohort studies and three observational datasets of MT randomized-controlled trial data reporting on IA fibrinolytics with MT as compared with MT alone, including 2797 patients (405 with additional IA fibrinolytics (100 urokinase (uPA), 305 tissue plasminogen activator (tPA)) and 2392 patients without IA fibrinolytics). Of 405 MT patients treated with additional IA fibrinolytics, 209 (51.6%) received prior intravenous tPA. We did not observe an increased risk of sICH after administration of IA fibrinolytics as adjunct to MT (OR 1.06, 95% CI 0.64 to 1.76), nor excess mortality (0.81, 95% CI 0.60 to 1.08). Although the mode of reporting was heterogeneous, some studies observed improved reperfusion after IA fibrinolytics. Conclusion The quality of evidence regarding peri-interventional administration of IA fibrinolytics in MT is low and limited to observational data. In highly selected patients, no increase in sICH was observed, but there is large uncertainty." @default.
- W3123276546 created "2021-02-01" @default.
- W3123276546 creator A5002472123 @default.
- W3123276546 creator A5003552461 @default.
- W3123276546 creator A5003759615 @default.
- W3123276546 creator A5006654860 @default.
- W3123276546 creator A5007955209 @default.
- W3123276546 creator A5011554054 @default.
- W3123276546 creator A5017689286 @default.
- W3123276546 creator A5019980438 @default.
- W3123276546 creator A5020320620 @default.
- W3123276546 creator A5020702592 @default.
- W3123276546 creator A5029210202 @default.
- W3123276546 creator A5033337810 @default.
- W3123276546 creator A5034122925 @default.
- W3123276546 creator A5038342943 @default.
- W3123276546 creator A5040154888 @default.
- W3123276546 creator A5047699396 @default.
- W3123276546 creator A5048297907 @default.
- W3123276546 creator A5052668764 @default.
- W3123276546 creator A5055453342 @default.
- W3123276546 creator A5059556142 @default.
- W3123276546 creator A5067250692 @default.
- W3123276546 creator A5073445438 @default.
- W3123276546 creator A5073996084 @default.
- W3123276546 creator A5074519999 @default.
- W3123276546 creator A5076072571 @default.
- W3123276546 creator A5080100010 @default.
- W3123276546 creator A5088764481 @default.
- W3123276546 date "2021-01-29" @default.
- W3123276546 modified "2023-10-17" @default.
- W3123276546 title "Safety and efficacy of intra-arterial fibrinolytics as adjunct to mechanical thrombectomy: a systematic review and meta-analysis of observational data" @default.
- W3123276546 cites W1971247823 @default.
- W3123276546 cites W2045124775 @default.
- W3123276546 cites W2126930838 @default.
- W3123276546 cites W2131192729 @default.
- W3123276546 cites W2132689928 @default.
- W3123276546 cites W2139621750 @default.
- W3123276546 cites W2168848392 @default.
- W3123276546 cites W2171058244 @default.
- W3123276546 cites W2269790923 @default.
- W3123276546 cites W2277258071 @default.
- W3123276546 cites W2511388967 @default.
- W3123276546 cites W2598003106 @default.
- W3123276546 cites W2621140147 @default.
- W3123276546 cites W2741644784 @default.
- W3123276546 cites W2747962553 @default.
- W3123276546 cites W2748472095 @default.
- W3123276546 cites W2749339225 @default.
- W3123276546 cites W2760763089 @default.
- W3123276546 cites W2783885397 @default.
- W3123276546 cites W2791187944 @default.
- W3123276546 cites W2793609248 @default.
- W3123276546 cites W2804424581 @default.
- W3123276546 cites W2808502365 @default.
- W3123276546 cites W2888794036 @default.
- W3123276546 cites W2890223142 @default.
- W3123276546 cites W2896839958 @default.
- W3123276546 cites W2900055315 @default.
- W3123276546 cites W2902226520 @default.
- W3123276546 cites W2905027998 @default.
- W3123276546 cites W2924359439 @default.
- W3123276546 cites W2944350557 @default.
- W3123276546 cites W2952204941 @default.
- W3123276546 cites W2982321961 @default.
- W3123276546 cites W2984519728 @default.
- W3123276546 cites W2986335210 @default.
- W3123276546 cites W2991979046 @default.
- W3123276546 cites W2998606486 @default.
- W3123276546 cites W4294215472 @default.
- W3123276546 doi "https://doi.org/10.1136/neurintsurg-2020-016680" @default.
- W3123276546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8606438" @default.
- W3123276546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33514609" @default.
- W3123276546 hasPublicationYear "2021" @default.
- W3123276546 type Work @default.
- W3123276546 sameAs 3123276546 @default.
- W3123276546 citedByCount "26" @default.
- W3123276546 countsByYear W31232765462021 @default.
- W3123276546 countsByYear W31232765462022 @default.
- W3123276546 countsByYear W31232765462023 @default.
- W3123276546 crossrefType "journal-article" @default.
- W3123276546 hasAuthorship W3123276546A5002472123 @default.
- W3123276546 hasAuthorship W3123276546A5003552461 @default.
- W3123276546 hasAuthorship W3123276546A5003759615 @default.
- W3123276546 hasAuthorship W3123276546A5006654860 @default.
- W3123276546 hasAuthorship W3123276546A5007955209 @default.
- W3123276546 hasAuthorship W3123276546A5011554054 @default.
- W3123276546 hasAuthorship W3123276546A5017689286 @default.
- W3123276546 hasAuthorship W3123276546A5019980438 @default.
- W3123276546 hasAuthorship W3123276546A5020320620 @default.
- W3123276546 hasAuthorship W3123276546A5020702592 @default.
- W3123276546 hasAuthorship W3123276546A5029210202 @default.
- W3123276546 hasAuthorship W3123276546A5033337810 @default.
- W3123276546 hasAuthorship W3123276546A5034122925 @default.
- W3123276546 hasAuthorship W3123276546A5038342943 @default.
- W3123276546 hasAuthorship W3123276546A5040154888 @default.
- W3123276546 hasAuthorship W3123276546A5047699396 @default.
- W3123276546 hasAuthorship W3123276546A5048297907 @default.