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• W3123280981 abstract "See Commentaries on pages 24 and 26.Central MessageOpen distal aortic repair is definitive and durable, remaining the gold standard treatment for chronic aortic dissection. See Commentaries on pages 24 and 26. Open distal aortic repair is definitive and durable, remaining the gold standard treatment for chronic aortic dissection. Recent guidelines define an aortic dissection as chronic after 90 days from the time of the initial event. This chronic state reflects the loss of compliance over time in the septum separating the true and false lumens of the dissection.1Lombardi J.V. Hughes G.C. Appoo J.J. Bavaria J.E. Beck A.W. Cambria R.P. et al.Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections.J Vasc Surg. 2020; 71: 723-747Abstract Full Text Full Text PDF PubMed Scopus (130) Google Scholar However, open repair of a dissection-related aneurysm of the distal aorta usually does not occur until years after the onset of dissection. The persistence of a pressurized false lumen weakens the outer aortic wall, leading to dilation and, possibly, to aneurysm (Figure 1).2Coselli J.S. Green S.Y. Price M.D. Hash J.A. Ouyang Y. Volguina I.V. et al.Results of open surgical repair in patients with Marfan syndrome and distal aortic dissection.Ann Thorac Surg. 2016; 101: 2193-2201Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar,3Schoenhoff F.S. Jungi S. Czerny M. Roost E. Reineke D. Matyas G. et al.Acute aortic dissection determines the fate of initially untreated aortic segments in Marfan syndrome.Circulation. 2013; 127: 1569-1575Crossref PubMed Scopus (71) Google Scholar Aneurysms due to chronic aortic dissection are present in 15% to 40% of patients who undergo open repair of descending thoracic aortic aneurysm or thoracoabdominal aortic aneurysm (TAAA).4Conrad M.F. Crawford R.S. Davison J.K. Cambria R.P. Thoracoabdominal aneurysm repair: a 20-year perspective.Ann Thorac Surg. 2007; 83: S856-S861Abstract Full Text Full Text PDF PubMed Scopus (294) Google Scholar, 5Coselli J.S. LeMaire S.A. Preventza O. de la Cruz K.I. Cooley D.A. Price M.D. et al.Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.J Thorac Cardiovasc Surg. 2016; 151: 1323-1337Abstract Full Text Full Text PDF PubMed Scopus (327) Google Scholar, 6Estrera A.L. Sandhu H.K. Charlton-Ouw K.M. Afifi R.O. Azizzadeh A. Miller III, C.C. et al.A quarter century of organ protection in open thoracoabdominal repair.Ann Surg. 2015; 262: 660-668Crossref PubMed Scopus (90) Google Scholar, 7Kulik A. Castner C.F. Kouchoukos N.T. Outcomes after thoracoabdominal aortic aneurysm repair with hypothermic circulatory arrest.J Thorac Cardiovasc Surg. 2011; 141: 953-960Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar In our series of 3309 patients who underwent TAAA repair, we found that 1020 (31%) had chronic aortic dissection; this included 427 (13%) survivors of DeBakey Type I and 593 (18%) survivors of DeBakey Type III aortic dissection.5Coselli J.S. LeMaire S.A. Preventza O. de la Cruz K.I. Cooley D.A. Price M.D. et al.Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.J Thorac Cardiovasc Surg. 2016; 151: 1323-1337Abstract Full Text Full Text PDF PubMed Scopus (327) Google Scholar These patients are distinctly different from those with degenerative atherosclerotic aneurysms. Patients with chronic aortic dissection are younger, have fewer comorbidities, and are more likely to have heritable thoracic aortic disease. In roughly one-third of patients who survive an acute dissection event (residual DeBakey Type I and index DeBakey Type III aortic dissection), a distal aortic aneurysm will subsequently develop.8Alfonsi J. Murana G. Smeenk H.G. Kelder H. Schepens M. Sonker U. et al.Open surgical repair of post-dissection thoraco-abdominal aortic aneurysms: early and late outcomes of a single-centre study involving over 200 patients.Eur J Cardiothorac Surg. 2018; 54: 382-388Crossref PubMed Scopus (15) Google Scholar Predictors of aneurysm development after aortic dissection include uncontrolled hypertension, initial aortic diameter >4.0 cm, entry tear >10 mm, partial thrombosis or continued patency of the distal false lumen, or false lumen >2.2 cm.9Bernard Y. Zimmermann H. Chocron S. Litzler J.F. Kastler B. Etievent J.P. et al.False lumen patency as a predictor of late outcome in aortic dissection.Am J Cardiol. 2001; 87: 1378-1382Abstract Full Text Full Text PDF PubMed Scopus (278) Google Scholar, 10Durham C.A. Aranson N.J. Ergul E.A. Wang L.J. Patel V.I. Cambria R.P. et al.Aneurysmal degeneration of the thoracoabdominal aorta after medical management of type B aortic dissections.J Vasc Surg. 2015; 62: 900-906Abstract Full Text Full Text PDF PubMed Scopus (44) Google Scholar, 11Fattouch K. Sampognaro R. Navarra E. Caruso M. Pisano C. Coppola G. et al.Long-term results after repair of type a acute aortic dissection according to false lumen patency.Ann Thorac Surg. 2009; 88: 1244-1250Abstract Full Text Full Text PDF PubMed Scopus (154) Google Scholar, 12Schwartz S.I. Durham C. Clouse W.D. Patel V.I. Lancaster R.T. Cambria R.P. et al.Predictors of late aortic intervention in patients with medically treated type B aortic dissection.J Vasc Surg. 2018; 67: 78-84Abstract Full Text Full Text PDF PubMed Scopus (51) Google Scholar The American College of Cardiology and American Heart Association guidelines for patients with thoracic aortic disease recommend open distal aortic repair when aortic diameter exceeds 5.5 cm (class I recommendation; level of evidence B), with a lower diameter threshold in patients with a rapid rate of growth (>0.5 cm/y) or heritable thoracic aortic disease.13Hiratzka L.F. Bakris G.L. Beckman J.A. Bersin R.M. Carr V.F. Casey Jr., D.E. et al.2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine.J Am Coll Cardiol. 2010; 55: e27-129Crossref PubMed Scopus (998) Google Scholar Symptomatic aneurysms can herald impending rupture and should be repaired, regardless of size.13Hiratzka L.F. Bakris G.L. Beckman J.A. Bersin R.M. Carr V.F. Casey Jr., D.E. et al.2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine.J Am Coll Cardiol. 2010; 55: e27-129Crossref PubMed Scopus (998) Google Scholar Other indications for open repair include compressive symptoms of adjacent structures or malperfusion syndromes. Notably, the open repair of chronic distal aortic dissection is generally performed on only the aneurysmal or symptomatic aortic segment.14Preventza O. Price M.D. Amarasekara H.S. Tullos A. Chen P. Reidy M.R. et al.Chronic Type I and Type III aortic dissections: a propensity analysis of outcomes after open distal repair.Eur J Cardiothorac Surg. 2018; 54: 510-516Crossref PubMed Scopus (12) Google Scholar Except in the most extensive repairs, a portion of residual chronic aortic dissection often remains after repair. Open repair of chronic aortic dissection remains the gold standard over thoracic endovascular aortic repair (TEVAR). With open repair, the thickened and stiff dissecting septum is excised, and a common lumen is created with the replacement graft. The durability of open repair has been well established. TEVAR is a burgeoning field; its application for the treatment of aortic dissection relies on covering the intimal tear and promoting aortic remodeling. However, in the chronic state, the thickened and noncompliant dissecting septum often prevents the complete elimination of false lumen blood flow, even if the entry tear is covered. The distal seal can be complicated by persistent retrograde blood flow into the false lumen, and new entry tears induced by the stent graft can develop at any point of coverage.15Hughes G.C. Stent graft-induced new entry tear (SINE): intentional and NOT.J Thorac Cardiovasc Surg. 2019; 157: 101-106Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar,16Andersen N.D. Keenan J.E. Ganapathi A.M. Gaca J.G. McCann R.L. Hughes G.C. Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting.Ann Cardiothorac Surg. 2014; 3: 264-274PubMed Google Scholar In fact, the aortic diameter fails to regress in 70% of patients with chronic aortic dissection who undergo TEVAR.17Conway A.M. Qato K. Mondry L.R. Stoffels G.J. Giangola G. Carroccio A. Outcomes of thoracic endovascular aortic repair for chronic aortic dissections.J Vasc Surg. 2018; 67: 1345-1352Abstract Full Text Full Text PDF PubMed Scopus (30) Google Scholar,18Sultan I. Siki M.A. Bavaria J.E. Dibble T.R. Savino D.C. Kilic A. et al.Predicting distal aortic remodeling after endovascular repair for chronic DeBakey III aortic dissection.Ann Thorac Surg. 2018; 105: 1691-1696Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar Adjunctive endovascular techniques to address the thickened, noncompliant dissecting septum include the following: obliteration of the false lumen, including embolization, by using coils or plugs; or, common aortic lumen creation by fenestration, stent-graft–assisted balloon aortic septal fracture, or provisional extension to induce complete attachment techniques.19Rohlffs F. Tsilimparis N. Fiorucci B. Heidemann F. Debus E.S. Kolbel T. The candy-plug technique: technical aspects and early results of a new endovascular method for false lumen occlusion in chronic aortic dissection.J Endovasc Ther. 2017; 24: 549-555Crossref PubMed Scopus (51) Google Scholar, 20Kölbel T. Carpenter S.W. Lohrenz C. Tsilimparis N. Larena-Avellaneda A. Debus E.S. Addressing persistent false lumen flow in chronic aortic dissection: the knickerbocker technique.J Endovasc Ther. 2014; 21: 117-122Crossref PubMed Scopus (95) Google Scholar, 21Iwakoshi S. Watkins C.A. Ogawa Y. Fischbein M. Lee A. Lee J.T. et al.Cheese wire fenestration of dissection intimal flap to facilitate thoracic endovascular aortic repair in chronic dissection.J Vasc Interv Radiol. 2020; 31: 150-154Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar, 22Kazimierczak A. Rynio P. Jędrzejczak T. Mokrzycki K. Samad R. Brykczyński M. et al.Expanded Petticoat technique to promote the reduction of contrasted false lumen volume in patients with chronic type B aortic dissection.J Vasc Surg. 2019; 70: 1782-1791Abstract Full Text Full Text PDF PubMed Scopus (11) Google Scholar We describe our operative technique involving a 4-branched replacement graft for the open repair of extent II TAAA aneurysms due to chronic aortic dissection. A careful review of preoperative imaging is the cornerstone of TAAA repair. The surgeon must plan for potential aortic clamping and cannulation sites with respect to calcification, dissection, and mural thrombus. Although rarely used at our institution, hypothermic circulatory arrest may be necessary if there is a contained rupture or if the distal aortic arch is aneurysmal and without a suitable proximal aortic clamping site. The origins of branching vessels, including the brachiocephalic, intercostal, lumbar, visceral, renal, and iliofemoral branches, are assessed with respect to the true lumen, false lumen, or both. Dissection extending into branch vessels may require fenestration. Anatomic variation should also be examined. A left renal vein that is retroaortic may need to be divided and later reconstructed with an interposition graft. The spatial orientations of the visceral and renal arteries are assessed with consideration of an island patch or individual branching grafts. The visceral and renal arteries are often displaced because of the chronic dissection. Therefore, we typically use a prefabricated 4-branched graft for the visceral and renal anastomoses. The use of this graft also avoids the formation of a late visceral patch aneurysm by eliminating the residual aortic tissue that remains after using alternate methods of a visceral artery reattachment (ie, the visceral island patch approach may form a subsequent aneurysm). Furthermore, the use of this graft reduces the anastomotic tension of this aortic region, thereby decreasing the likelihood of late pseudoaneurysm formation, which is particularly important in patients with heritable thoracic aortic disease. Standard intravenous lines are inserted, including a central venous access line. A Swan-Ganz catheter and a right-sided upper extremity arterial line are obtained for hemodynamic monitoring. A double-lumen endotracheal tube is used to facilitate single-lung ventilation. The aneurysm may distort the airway such that it is difficult to navigate a double-lumen endotracheal tube. When anatomically necessary, our second choice is to insert a bronchial blocker. Our practice is to transfer the patient to the intensive care unit with the double-lumen endotracheal tube in place and exchange to a single-lumen endotracheal tube if we anticipate a prolonged course of mechanical ventilation. The patient's temperature passively cools to a mildly hypothermic temperature (32°C-33°C). Core temperature is measured by using a temperature probe in the nasopharynx. Cerebral oximetry is monitored throughout the procedure. Although spinal cord function may be assessed during repair by using motor-evoked potential monitoring or near-infrared spectroscopy monitoring, we do not routinely use these techniques. In our previous experience with neuromonitoring, we had logistical issues with obtaining and interpreting useful information. Ultimately, we did not adopt these monitoring techniques into our practice; however, other aortic centers have demonstrated benefits with using motor-evoked potentials.23Jacobs M.J. Mess W. Mochtar B. Nijenhuis R.J. Statius van Eps R.G. Schurink G.W. The value of motor evoked potentials in reducing paraplegia during thoracoabdominal aneurysm repair.J Vasc Surg. 2006; 43: 239-246Abstract Full Text Full Text PDF PubMed Scopus (171) Google Scholar We utilize a multimodal approach to prevent spinal cord, visceral, and renal artery injury during TAAA repair. Cerebral spinal fluid (CSF) drainage is used for extent I and II repairs, for extent III repairs with the anticipation of replacing the iliac arteries, and for extent IV repairs with prior descending thoracic aneurysm or extent I repair. The CSF pressure is kept below 15 mm Hg, and CSF is drained at a maximum rate of 10 mL/h or 25 mL over 4 hours. The CSF drain is secured to the patient's right back. In most cases, a left heart bypass (LHB) circuit with a cell saver for autotransfusion is used; however, a complete cardiopulmonary bypass circuit is used in cases requiring hypothermic circulatory arrest (18°C-20°C). Additionally, we utilize passive mild hypothermia, sequential crossclamping, aggressive reimplantation of suitable intercostal or lumbar arteries, isothermic blood from the LHB circuit to perfuse the celiac axis and superior mesenteric artery, and cold renal solution to protect the kidneys.24Coselli J.S. Green S.Y. Price M.D. Zhang Q. Preventza O. de la Cruz K.I. et al.Spinal cord deficit after 1114 extent II open thoracoabdominal aortic aneurysm repairs.J Thorac Cardiovasc Surg. 2020; 159: 1-13Abstract Full Text Full Text PDF Scopus (27) Google Scholar, 25Coselli J.S. LeMaire S.A. Left heart bypass reduces paraplegia rates after thoracoabdominal aortic aneurysm repair.Ann Thorac Surg. 1999; 67: 1931-1934Abstract Full Text Full Text PDF PubMed Scopus (172) Google Scholar, 26Coselli J.S. LeMaire S.A. Koksoy C. Schmittling Z.C. Curling P.E. Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair: results of a randomized clinical trial.J Vasc Surg. 2002; 35: 631-639Abstract Full Text Full Text PDF PubMed Scopus (505) Google Scholar The mean arterial pressure is kept between 70 and 90 mm Hg, measured from the right-sided upper extremity. The patient is placed in the right lateral decubitus position with the upper body at 60° and the hips at 30° with respect to horizon by using a beanbag (Figure 2, A). The left arm is placed on an arm board at an angle above the shoulders in a freestyle swimming position. The table is flexed at the waist. This position allows for adequate exposure of the TAAA and femoral arteries. A sigmoid skin incision is made from the left scapula, along the seventh rib, across the costal margin, to the left of the umbilicus. The ribs are counted, and the sixth intercostal space is entered with the left lung collapsed. A short segment of the posterior rib may be removed to improve thoracic exposure and to prevent rib fracture from excessive retraction.Figure 2Repair of chronic aortic dissection in a patient with a Crawford extent II thoracoabdominal aortic aneurysm. A, Positioning of the patient and incision for thoracoabdominal extent II repair. B, Preparation of the proximal aorta, including the initiation of left heart bypass. The dissecting septum is excised (inset). C, Sizing of a branched aortic graft with respect to the visceral and renal branches. D, Construction of the proximal anastomosis. Left heart bypass is used. E, Exposure of the distal length of the aorta. F, Visceral perfusion and patch anastomosis of pairs of intercostal arteries. G, Expedited construction of the distal anastomosis when a branched graft is used. H, Construction of right renal anastomosis. Construction of the superior mesenteric artery anastomosis, celiac axis, and left renal artery (inset). I, The completed extent II thoracoabdominal aortic repair. All figures used with permission of Baylor College of Medicine.View Large Image Figure ViewerDownload Hi-res image Download (PPT) The diaphragm is divided circumferentially, leaving a 3- to 4-cm rim of tissue from the left costal margin to the aortic hiatus to preserve the neurovascular supply of the diaphragm. The peritoneum is carefully opened, ensuring that the stomach, transverse colon, and liver are not injured. Left medial visceral rotation is performed by entering the avascular plane along the line of Toldt. The stomach is palpated to ensure its adequate decompression and that the nasal gastric tube is suitably placed. The nasal gastric tube is used as a marker for the esophagus. The left ureter is identified and retracted medially with the viscera. The left renal artery is used as a landmark, and the aorta is dissected free of its fibrofatty attachments. Throughout the procedure, meticulous hemostasis is obtained during exposure to prevent blood loss and its sequela of impaired oxygen delivery and coagulopathy. The proximal aorta is circumferentially freed while protecting the left recurrent laryngeal nerve. Adhesions from a prior DeBakey Type I aortic dissection repair may increase the difficulty in preparing the proximal aorta for a crossclamp. An elephant trunk extension during the index proximal aortic repair simplifies the staged TAAA repair.27LeMaire S.A. Carter S.A. Coselli J.S. The elephant trunk technique for staged repair of complex aneurysms of the entire thoracic aorta.Ann Thorac Surg. 2006; 81: 1561-1569Abstract Full Text Full Text PDF PubMed Scopus (146) Google Scholar Epiaortic ultrasound may be helpful to locate the free-floating elephant trunk graft within the proximal portion of the descending thoracic aorta. LHB for isothermic, self-oxygenated blood perfusion is facilitated by inserting a drainage cannula in the left atrium via the left inferior pulmonary vein and a return cannula in the distal aorta. Careful review of preoperative imaging aids the selection of a cannulation site free of thick thrombus. Although the true lumen is ideally cannulated, multiple entry tears are common in the dissecting septum, which typically ensures comprehensive perfusion even if the false lumen is cannulated. Epiaortic ultrasound may also aid the identification of a suitable distal aortic cannulation site. Heparin is administered (1.5 mg/kg) to achieve an activated clotting time >280 seconds before the initiation of LHB at a flow of 500 mL/min, which is then increased to 3.5 L/min once the aortic crossclamp is applied. In patients with chronic aortic dissection, the distal arch tends to be dilated. A straight, padded aortic crossclamp is applied, distal to the left subclavian artery whenever possible; more commonly, it is placed proximal to the left subclavian artery. If a crossclamp is placed proximal to the left subclavian artery, then a bulldog clamp is applied across the left subclavian artery, and cerebral oximetry is monitored to ensure that blood flow to the left common carotid is not compromised. A Crafoord clamp is applied distally at the T6 to T7 vertebral level to preserve flow where the artery of Adamkiewicz commonly arises (T7-L1). The isolated aortic segment is checked to determine whether it is depressurized by gently milking the blood before distal aortic clamping. LHB flow is increased to 3.5 L/min, and a mean arterial pressure between 70 and 90 mm Hg is maintained from the right upper extremity arterial line. The aorta is opened longitudinally, and the aortic edges are retracted with stay sutures. The chronic dissection membrane is excised, effectively creating a single lumen. Briskly back-bleeding intercostal arteries are ligated with figure-of-8 sutures to improve visualization, minimize hemorrhage, and prevent shunting of blood from the spinal cord. In instances of hypothermic circulatory arrest, fenestration should be carried out proximally under visualization. We are careful to not aggressively excise aortic tissue, given that a transmural cut would be extremely difficult to repair in the proximal aortic arch. The aorta is trimmed for the proximal anastomosis, leaving a rim of approximately 3 cm (Figure 2, B). The backwall of the aorta is dissected off the esophagus to avoid including esophageal tissue in the anastomosis, which may lead to an aortoesophageal fistula. The distance from the proximal anastomosis to the visceral branches is measured by gently stretching the graft and trimming it to an approximate length (Figure 2, C). A 3-0 polypropylene suture is used in a continuous fashion; however, a 4-0 or 5-0 suture is used in patients with heritable thoracic aortic disorders. A 24- to 28-mm Dacron (DuPont, Newark, Del) graft impregnated with gelatin is typically used, which is then soaked in rifampin tableside. The anastomosis is started at the posterolateral corner and is continued medially while ensuring all layers of the aorta are included (Figure 2, D). After completion of the primary suture line, the graft is gently retracted and carefully examined for gaps, overlapping sutures, or tears in the aorta. Pledgeted mattress sutures are liberally applied to ensure a secure anastomosis, given that mean arterial pressure targets are higher during the postoperative period. The proximal crossclamp is then moved onto the graft. This clamp movement is particularly important when the clamp was placed proximal to the left subclavian artery because it re-establishes flow to the left subclavian and right vertebral artery. LHB is weaned, and the distal cannula and distal crossclamp are removed. The aorta is opened longitudinally (Figure 2, E). The dissecting membrane is excised, and thrombus is removed, allowing exposure of the intercostal, visceral, and lumbar branches. Briskly back-bleeding intercostal or lumbar arteries are oversewn. Selective visceral perfusion is performed with isothermic, self-oxygenated blood through balloon-tipped catheters into the celiac axis and superior mesenteric artery at a flow of 600 mL/min via a Y-branch off the LHB (Figure 3). The renal arteries are protected with cold (4°C) perfusate (300 mL every 6-12 minutes) via balloon-tipped catheters on a standalone cooling circuit while the nasopharyngeal temperature is monitored (Figure 3) not to drop below 32°C to prevent hypothermia-induced arrythmias. We adjust the volume and timing of the renal perfusate on the basis of the patient's temperature. An alternate perfusion strategy involves rerouting the LHB circuit with additional balloon-tipped catheters to provide isothermic, self-oxygenated blood to all 4 branching arteries. We identify 2 or 3 pairs of arteries between T7 and L2 that are large and have minimal or no back-bleeding to be utilized for reimplantation with an island patch or, less commonly, an 8-mm interposition Dacron graft (Figure 2, F). We typically reimplant using an island patch as a side-to-side anastomosis with 3-0 polypropylene suture. Occasionally, if the pairs of intercostal or lumbar arteries are spaced far apart, 2 island patches are used. To reduce the risk of subsequent pseudoaneurysm formation, we minimize the inclusion of native aorta in the patch. Pledgeted mattress sutures are used for reinforcement if the aortic tissue is fragile. The proximal crossclamp is then moved distally to the island patch to perfuse the spinal cord through the intercostal or lumbar arterial patch. When a 4-branched replacement graft is used, the distal anastomosis is performed before reattachment of the visceral and renal arteries; this facilitates continued visceral and renal perfusion. The distal aortic anastomosis is usually sewn to the aortic bifurcation but can be constructed to the iliac or femoral arteries, as well (Figure 2, G). If the chronic dissection extends distally, the septum is fenestrated. The aortic graft is trimmed to the suitable length to prevent kinking or tension, and 3-0 polypropylene suture is used in a continuous fashion. Pledgeted mattress sutures are used to reinforce the anastomosis. The patient is placed in the Trendelenburg position, and a 19-gauge needle is used to create de-airing holes. Individual clamps are placed on each of the 4 branches. The crossclamp is slowly removed to re-establish blood flow to the lower body. Anesthesia should be prepared to resuscitate the patient to maintain mean arterial pressure upon crossclamp removal; typically, the use of bicarbonate and vasopressors is necessary. The ostia of the visceral and renal arteries are cut with a rim of aortic tissue to create buttons and are carefully inspected for dissection, calcium, or stenosis. If the dissection extends into the visceral arteries, fenestration is carried out on the distal aspect of the affected artery to ensure perfusion through both lumens. Endarterectomy, decalcification, or direct stenting (usually a 7-mm × 15-mm balloon-expandable stent) may be required. The perfusion catheters are kept in place to limit ischemic time. The right renal artery is most posterior and is sewn first by using 4-0 or 5-0 polypropylene suture (Figure 2, H). The anastomosis is de-aired, and the clamp is released to re-establish perfusion. Then, the superior mesenteric artery and celiac axis anastomoses are carried out. We typically leave the superior mesenteric artery clamped during the celiac axis anastomosis to prevent back-bleeding, which affects visualization. Last, the left renal artery anastomosis is sewn. The inferior mesenteric artery is oversewn but may need to be reimplanted when there are bilateral hypogastric artery occlusions, prior colectomy, or a diseased superior mesenteric artery. The 4-branched graft (Figure 2, I) is inspected for malorientation, and the distal pulse of the femoral arteries, renal arteries, celiac axis, and superior mesenteric artery are palpated. The bowel is visualized to confirm it is well perfused, and the kidneys are palpated for turgor. The spleen is inspected for any laceration or hematoma. Any splenic injury that cannot be controlled with electrocautery or packing will require a splenectomy. The patient is passively rewarmed to a target temperature of >34.5°C. The position of the nasal gastric tube should be confirmed. A closed-suction abdominal drain is placed in the upper left retroperitoneal space. The left hemidiaphragm is reapproximated with #1 polypropylene continuous suture that is locked every 3 bites to maintain tension. Two chest tubes are placed: 1 anterosuperiorly and the other posteroinferiorly. Absorbable pericostal sutures are placed in around the ribs in a figure-of-8, interrupted fashion with #2 coated braided polyester sutures. Two #7 steel wires are also placed to secure the thoracotomy closure. The abdominal fascia is closed and tied to the diaphragmatic suture. Ventilation of the left lung is resumed, and the soft tissue is closed. Standard intensive care monitoring and volume resuscitation form the cornerstone of postoperative care in patients with TAAA. The mean arterial pressure is maintained between 80 and 100 mm Hg, and the patient's neurologic status is checked every hour. The patient's hemoglobin level is kept at or above 10 g/dL. The CSF drain can be removed between 48 and 72 hours postoperatively if there are no spinal deficits. The CSF drain is usually clamped for 8 to 12 hours before removal. The patient may be extubated the day after surgery and slowly started on a solid diet on postoperative day 4. Typically, patients are discharged 7 to 10 days after open repair. Higher mean arterial pressure goals are maintained for 4 to 6 weeks after surgery to prevent late neurologic complications. In contemporary studies of distal aortic repair due to chronic dissection, the early mortality rate is 6% to 8%, the stroke rate is 1% to 4%, the incidence of paraplegia is 1% to 3%, and the incidence of renal failure requiring dialysis is 4% to 5%.8Alfonsi J. Murana G. Smeenk H.G. Kelder H. Schepens M. Sonker U. et al.Open surgical repair of post-dissection thoraco-abdominal aortic aneurysms: early and late outcomes of a single-centre study involving over 200 patients.Eur J Cardiothorac Surg. 2018; 54: 382-388Crossref PubMed Scopus (15) Google Scholar,14Preventza O. Price M.D. Amarasekara H.S. Tullos A. Chen P. 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Additionally, Kouchoukos and colleagues35Kouchoukos N.T. Kulik A. Castner C. Branch graft patency after open repair of thoracoabdominal aortic aneurysms.J Thorac Cardiovasc Surg. 2017; 153: S14-S19Abstract Full Text Full Text PDF PubMed Scopus (17) Google Scholar reported excellent patency of branch grafts on follow-up angiography, with 93% freedom from occlusion at 10 years." @default.
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