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- W3123313222 abstract "Abstract Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is key for the secondary prevention of recurrent ischemic events and stent thrombosis after percutaneous coronary intervention. Yet, throughout its duration, DAPT is associated with an increased risk of bleeding compared to aspirin alone and a potential negative impact on prognosis. Hence, while secondary prevention with aspirin monotherapy is generally maintained for an indefinite period, the duration of DAPT after the index event is debated. In this chapter, we sought to highlight the clinical relevance of bleeding events in patients with coronary artery disease, discuss the current knowledge on bleeding risk evaluation, and critically appraise the evidence from randomized controlled trials evaluating the risks and benefits of short-term DAPT duration. We provide a special focus on treatment individualization algorithms identifying patients in whom the use of short-term DAPT has to be prioritized, based on most recent evidence." @default.
- W3123313222 created "2021-02-01" @default.
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- W3123313222 date "2021-01-01" @default.
- W3123313222 modified "2023-09-23" @default.
- W3123313222 title "Competing risks in the duration of dual antiplatelet therapy—the case for shorter treatment" @default.
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- W3123313222 doi "https://doi.org/10.1016/b978-0-12-820536-5.00001-x" @default.
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