FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123327712> ?p ?o ?g. }

• W3123327712 endingPage "303" @default.
• W3123327712 startingPage "301" @default.
• W3123327712 abstract "Despite great advances in the field of intensive care, when patients survive a severe brain injury but remain in a chronic Vegetative State (VS) or Minimally Conscious State (MCS) (i.e., a disorder of consciousness; DOC), little can be done to promote recovery [[1]Schnakers C. Monti M.M. Disorders of consciousness after severe brain injury: therapeutic options.Curr Opin Neurol. 2017; 30: 573-579Crossref PubMed Scopus (21) Google Scholar]. To date, several restorative strategies have been investigated in DOC patients—all proposed to exert their effects via direct or indirect upregulation of excitatory thalamic output and, in turn, upregulation of a large scale cortico-striato-pallido-thalamo-cortical mesocircuit [[1]Schnakers C. Monti M.M. Disorders of consciousness after severe brain injury: therapeutic options.Curr Opin Neurol. 2017; 30: 573-579Crossref PubMed Scopus (21) Google Scholar,[2]Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis.Trends Neurosci. 2010; 33: 1-9Abstract Full Text Full Text PDF PubMed Scopus (304) Google Scholar]. For instance, high-quality evidence supports the use of amantadine and transcranial direct current stimulation (tDCS) in sub-acute patients [[1]Schnakers C. Monti M.M. Disorders of consciousness after severe brain injury: therapeutic options.Curr Opin Neurol. 2017; 30: 573-579Crossref PubMed Scopus (21) Google Scholar]; however, considerably less evidence exists in chronic patients. Indeed, despite the remarkable results obtained with thalamic deep brain stimulation (DBS) in one chronic patient [[2]Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis.Trends Neurosci. 2010; 33: 1-9Abstract Full Text Full Text PDF PubMed Scopus (304) Google Scholar], a 7-year prospective clinical trial evaluating the use of this technique in a larger sample highlights the limited applicability of the technique [[3]Magrassi L. et al.Results of a prospective study (CATS) on the effects of thalamic stimulation in minimally conscious and vegetative state patients.J Neurosurg. 2016; 125: 972-981Crossref PubMed Scopus (30) Google Scholar], inviting the development of alternative approaches to direct thalamic stimulation. The rapid (re)development of low intensity focused ultrasound (LIFU) as a means of reversible modulation of (subcortical) brain tissue offers a potential alternative to DBS for restorative intervention in DOC. The bioactivity of LIFU in neural tissue has now been shown in vitro, in non-human animal models, and in healthy human volunteers [[4]Blackmore J. Shrivastava S. Sallet J. Butler C.R. Cleveland R.O. Ultrasound neuromodulation: a review of results, mechanisms and safety.Ultrasound Med Biol. 2019; 45: 1509-1536Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar]. Relevant here, thalamic LIFU has been associated with faster behavioral recovery from anesthesia in animal models [[5]Yoo S.-S. Kim H. Min B.-K. Eric Franck S.P. Transcranial focused ultrasound to the thalamus alters anesthesia time in rats.Neuroreport. 2011; 22: 783-787Crossref PubMed Scopus (59) Google Scholar], and a case report of thalamic LIFU in acute DOC confirms this approach’s clinical viability [[6]Monti M.M. Schnakers C. Korb A.S. Bystritsky A. Vespa P.M. Non-invasive ultrasonic thalamic stimulation in disorders of consciousness after severe brain injury: a first-in-man report.Brain Stimul: Basic Transl Clin Res Neuromodul. 2016; 9: 940-941Abstract Full Text Full Text PDF PubMed Scopus (90) Google Scholar]. We report the very first application of thalamic LIFU in three patients with chronic DOC, as part of a first-in-man clinical trial (NCT02522429; UCLA approved IRB #14–001749). Patients underwent two MR-guided thalamic LIFU sessions one week apart while behavioral assessments using the JFK Coma Recovery Scale–Revised (CRS-R) [[7]Giacino J.T. Kalmar K. Whyte J. The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility.Arch Phys Med Rehabil. 2004; 85: 2020-2029Abstract Full Text Full Text PDF PubMed Scopus (1028) Google Scholar] were utilized at 12 time points to assess the therapeutic potential of the LIFU procedure. In each session, LIFU was applied at 100 Hz pulse repetition frequency (PRF), 0.5 ms pulse width (PW), 650 kHz carrier wave frequency, 5% duty cycle, and 14.39 Wcm2 ISPPA.3/719.73 mWcm2 ISPTA.3. The transducer (Brainsonix) was positioned using MR-guidance such that its focus (55mm from its surface) lay over the left central thalamus [[2]Schiff N.D. Recovery of consciousness after brain injury: a mesocircuit hypothesis.Trends Neurosci. 2010; 33: 1-9Abstract Full Text Full Text PDF PubMed Scopus (304) Google Scholar], at which point sonication was delivered inside the MRI scanner for ten 30-s blocks, separated by 30s off periods (cf., Fig. 1a and b). Phenotypes of Patients at Baseline: At baseline, Patient 1 (male, age 56, 14.5 months PI [post-injury]—hemorrhagic stroke) displayed behaviors consistent with a minimally conscious state “plus” (MCS+), including reproducible response to command, object recognition, and non-functional communication (CRS-R: 16; CRS-R index [[8]Annen J. et al.Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness.Brain Inj. 2019; 33: 1409-1412Crossref PubMed Scopus (10) Google Scholar]: 55.9). Patient 2 (female, age 50, 32 months PI—cardiac arrest/hypoxia) demonstrated behaviors consistent with MCS “minus” (MCS-), including visual fixation and no response to command (CRS-R: 9; CRS-R index: 15.96). Patient 3 (male, age 58, 66 months PI—motor vehicle accident) displayed behaviors consistent with MCS+, including response to command (finger movement) and object recognition (distinguishing relatives in pictures) (CRS-R: 16; CRS-R index: 65.28). Results, Phenotypes of Patients Following LIFU: We highlight three initial results. First, this report shows that MR-guided LIFU is feasible in (outpatient) chronic DOC patients. Second, the intervention appears to be well tolerated and safe; no alteration in vital parameters (blood pressure, heart rate, blood oxygen), evidence of structural damage, or any other adverse event were noted. Third, although these results must be understood as preliminary, two out of three patients exhibited clinically significant increases in behavioral responsiveness after exposure to each dose of thalamic LIFU, compared to baseline. In the week following the first LIFU exposure, Patient 1 (baseline MCS+) demonstrated, for the first time, the ability to perform consistent response to two distinct commands and a highly accurate rate of response to autobiographical questions (i.e., 5/6). In the days following the second LIFU exposure, patient 1 also demonstrated, for the first time, the ability to functionally use two different objects (i.e., proper use of a pen on paper, bottle-to-mouth) as well as to functionally communicate (6/6 question-response pairs). Importantly, these behaviors are diagnostic markers of emergence from MCS and thus from a disorder of consciousness. Nonetheless, at 3-month and 6-month follow-up visits, the patient regressed to a neurobehavioral profile consistent with MCS+. Patient 2 (baseline MCS-) demonstrated, also for the first time, reproducible response to command (head, finger movement, 3/4 times each) shortly after the first LIFU exposure, with this behavior becoming systematic (head motion, 4/4 times) in the days following (prior to the second LIFU exposure). This behavior is consistent with MCS+. The patient also exhibited, for the first time, the ability to recognize different objects (pencil, comb) following the first LIFU. MCS+ categorization was maintained throughout follow-up assessments. Importantly, these novel behaviors had not been observed prior to the procedure by our team or their families (see supplement), despite the years since onset. Finally, patient 3, who began as MCS+, did not show any benefit of either exposure to LIFU. In fact, the patient only exhibited lower-level behaviors, consistent with MCS- (visual pursuit and automatic motor response), until the first follow-up, when higher-level behaviors typical of MCS+ were observed again (cf., Fig. 1c for CRS-R (index) ) over assessments). While exciting, alternative explanations should be considered. First, the CRS-R assessment has been shown to minimize diagnostic error (where, importantly, diagnosis is based on the highest level of responding) to less than 5% only after 5 administrations whereas our baseline only included three (17% chance of error [[9]Wannez S. Heine L. Thonnard M. Gosseries O. Laureys S. The repetition of behavioral assessments in diagnosis of disorders of consciousness.Ann Neurol. 2017; 81: 883-889Crossref PubMed Scopus (113) Google Scholar]). However, patient 1 exhibited novel behaviors consistent with eMCS (emergence from MCS) on the 10th examination and patient 2 exhibited systematic response to command on the 6th examination, while published estimates show no benefit of additional assessments beyond the 5th [[9]Wannez S. Heine L. Thonnard M. Gosseries O. Laureys S. The repetition of behavioral assessments in diagnosis of disorders of consciousness.Ann Neurol. 2017; 81: 883-889Crossref PubMed Scopus (113) Google Scholar]. Yet, future investigations should be mindful of the recently shown need for extended baseline measurements [[9]Wannez S. Heine L. Thonnard M. Gosseries O. Laureys S. The repetition of behavioral assessments in diagnosis of disorders of consciousness.Ann Neurol. 2017; 81: 883-889Crossref PubMed Scopus (113) Google Scholar]. Second, albeit less frequently than in acute DOC, spontaneous recovery does occur in chronic patients [[10]Whyte J. et al.Functional outcomes in traumatic disorders of consciousness: 5-year outcomes from the national institute on disability and rehabilitation research traumatic brain injury model systems.Arch Phys Med Rehabil. 2013; 94: 1855-1860Abstract Full Text Full Text PDF PubMed Scopus (61) Google Scholar]. Nonetheless, this has been characterized over the course of months and years post-injury, not over the span of days and weeks, making it unlikely that our findings are simply due to spontaneous recovery, particularly for non-traumatic patients. Third, assessments were unblinded with respect to the LIFU procedure—which produced indicators (e.g., hair removal)—and thus could be susceptible to biases. These findings should compel double-blind and controlled procedures in future confirmatory work. Nonetheless, these preliminary findings suggest that LIFU has potential as a novel, safe, and broadly applicable intervention for patients with chronic DOC. MMM and CS conceived the study. JAC, MMM, and NMS administered the ultrasound. CS supervised behavioral assessments. JAC, NMS, and CS performed behavioral assessments. JPC, JSC, MAJ, and ESL assisted in planning, preliminary data collection, and ultrasound device management. JAC, MMM, and CS wrote the first draft of the paper. CR, MBB, and PMV oversaw patient wellbeing while in Ronald Reagan hospital, provided medical guidance, and assisted in the patient admission process. All listed authors reviewed this paper and provided feedback. The authors declare no competing interests. This work was funded by the Tiny Blue Dot Foundation and the Dana foundation (to MMM). The following is the Supplementary data to this article: Download .docx (.03 MB) Help with docx files Multimedia component 1" @default.
• W3123327712 created "2021-02-01" @default.
• W3123327712 creator A5008498728 @default.
• W3123327712 creator A5017601757 @default.
• W3123327712 creator A5022801729 @default.
• W3123327712 creator A5030206822 @default.
• W3123327712 creator A5039210874 @default.
• W3123327712 creator A5049203054 @default.
• W3123327712 creator A5054067532 @default.
• W3123327712 creator A5056260505 @default.
• W3123327712 creator A5063250341 @default.
• W3123327712 creator A5073633184 @default.
• W3123327712 creator A5087948456 @default.
• W3123327712 date "2021-03-01" @default.
• W3123327712 modified "2023-09-27" @default.
• W3123327712 title "Ultrasonic thalamic stimulation in chronic disorders of consciousness" @default.
• W3123327712 cites W1989167946 @default.
• W3123327712 cites W2033349308 @default.
• W3123327712 cites W2044022758 @default.
• W3123327712 cites W2159221444 @default.
• W3123327712 cites W2230401966 @default.
• W3123327712 cites W2479099656 @default.
• W3123327712 cites W2620421155 @default.
• W3123327712 cites W2755584472 @default.
• W3123327712 cites W2944853512 @default.
• W3123327712 cites W2962686550 @default.
• W3123327712 doi "https://doi.org/10.1016/j.brs.2021.01.008" @default.
• W3123327712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33465497" @default.
• W3123327712 hasPublicationYear "2021" @default.
• W3123327712 type Work @default.
• W3123327712 sameAs 3123327712 @default.
• W3123327712 citedByCount "49" @default.
• W3123327712 countsByYear W31233277122021 @default.
• W3123327712 countsByYear W31233277122022 @default.
• W3123327712 countsByYear W31233277122023 @default.
• W3123327712 crossrefType "journal-article" @default.
• W3123327712 hasAuthorship W3123327712A5008498728 @default.
• W3123327712 hasAuthorship W3123327712A5017601757 @default.
• W3123327712 hasAuthorship W3123327712A5022801729 @default.
• W3123327712 hasAuthorship W3123327712A5030206822 @default.
• W3123327712 hasAuthorship W3123327712A5039210874 @default.
• W3123327712 hasAuthorship W3123327712A5049203054 @default.
• W3123327712 hasAuthorship W3123327712A5054067532 @default.
• W3123327712 hasAuthorship W3123327712A5056260505 @default.
• W3123327712 hasAuthorship W3123327712A5063250341 @default.
• W3123327712 hasAuthorship W3123327712A5073633184 @default.
• W3123327712 hasAuthorship W3123327712A5087948456 @default.
• W3123327712 hasBestOaLocation W31233277121 @default.
• W3123327712 hasConcept C126322002 @default.
• W3123327712 hasConcept C126838900 @default.
• W3123327712 hasConcept C15744967 @default.
• W3123327712 hasConcept C169760540 @default.
• W3123327712 hasConcept C17329761 @default.
• W3123327712 hasConcept C186720457 @default.
• W3123327712 hasConcept C24998067 @default.
• W3123327712 hasConcept C2777938509 @default.
• W3123327712 hasConcept C2778170955 @default.
• W3123327712 hasConcept C2778542668 @default.
• W3123327712 hasConcept C2779134260 @default.
• W3123327712 hasConcept C2779246727 @default.
• W3123327712 hasConcept C2779734285 @default.
• W3123327712 hasConcept C2910642945 @default.
• W3123327712 hasConcept C71924100 @default.
• W3123327712 hasConcept C81288441 @default.
• W3123327712 hasConceptScore W3123327712C126322002 @default.
• W3123327712 hasConceptScore W3123327712C126838900 @default.
• W3123327712 hasConceptScore W3123327712C15744967 @default.
• W3123327712 hasConceptScore W3123327712C169760540 @default.
• W3123327712 hasConceptScore W3123327712C17329761 @default.
• W3123327712 hasConceptScore W3123327712C186720457 @default.
• W3123327712 hasConceptScore W3123327712C24998067 @default.
• W3123327712 hasConceptScore W3123327712C2777938509 @default.
• W3123327712 hasConceptScore W3123327712C2778170955 @default.
• W3123327712 hasConceptScore W3123327712C2778542668 @default.
• W3123327712 hasConceptScore W3123327712C2779134260 @default.
• W3123327712 hasConceptScore W3123327712C2779246727 @default.
• W3123327712 hasConceptScore W3123327712C2779734285 @default.
• W3123327712 hasConceptScore W3123327712C2910642945 @default.
• W3123327712 hasConceptScore W3123327712C71924100 @default.
• W3123327712 hasConceptScore W3123327712C81288441 @default.
• W3123327712 hasFunder F4320306305 @default.
• W3123327712 hasIssue "2" @default.
• W3123327712 hasLocation W31233277121 @default.
• W3123327712 hasOpenAccess W3123327712 @default.
• W3123327712 hasPrimaryLocation W31233277121 @default.
• W3123327712 hasRelatedWork W1999282796 @default.
• W3123327712 hasRelatedWork W2057152734 @default.
• W3123327712 hasRelatedWork W2057238759 @default.
• W3123327712 hasRelatedWork W2162093890 @default.
• W3123327712 hasRelatedWork W2171889351 @default.
• W3123327712 hasRelatedWork W2325491465 @default.
• W3123327712 hasRelatedWork W2460842794 @default.
• W3123327712 hasRelatedWork W2563867255 @default.
• W3123327712 hasRelatedWork W3164700944 @default.
• W3123327712 hasRelatedWork W4235944274 @default.
• W3123327712 hasVolume "14" @default.
• W3123327712 isParatext "false" @default.
• W3123327712 isRetracted "false" @default.

• next