FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123435912> ?p ?o ?g. }

• W3123435912 abstract "Renal interstitial fibrosis is the most important pathological process in chronic renal failure. Previous studies have shown that poricoic acid A (PAA), the main chemical constituent on the surface layer of the mushroom <em>Poria cocos</em>, has protective effects against oxidative stress and acute kidney injury. The present study aimed to investigate the potential roles of PAA on the pathological process of renal fibrosis and the associated molecular mechanism. The NRK‑49F cell line was treated with transforming growth factor‑β1 (TGF‑β1) with or without PAA or platelet‑derived growth factor C (PDGF‑C). Cell Counting Kit‑8 assay, western blotting and 5‑ethynyl‑2'‑deoxyuridine immunofluorescence staining were performed to examine cell growth, protein expression and cell proliferation, respectively. Data from the present study showed that 10 µM PAA attenuated TGF‑β1‑induced NRK‑49F cell extracellular matrix (ECM) accumulation, fibrosis formation and proliferation. Renal fibrosis with the activation of Smad3 and mitogen‑activated protein kinase (MAPK) pathways were also inhibited by PAA treatment. PDGF‑C reversed the inhibitory effects of PAA on TGF‑β1‑induced renal fibroblast proliferation and activation of the Smad3/MAPK pathway. The present study suggested that suppression of TGF‑β1‑induced renal fibroblast ECM accumulation, fibrosis formation and proliferation by PAA is mediated via the inhibition of the PDGF‑C, Smad3 and MAPK pathways. The present findings not only revealed the potential anti‑fibrotic effects of PAA on renal fibroblasts, but also provided a new insight into the prevention of fibrosis formation via regulation of the PDGF‑C, Smad3 and MAPK signaling pathways." @default.
• W3123435912 created "2021-02-01" @default.
• W3123435912 creator A5004810018 @default.
• W3123435912 creator A5033707023 @default.
• W3123435912 creator A5069771802 @default.
• W3123435912 creator A5087209680 @default.
• W3123435912 date "2021-01-27" @default.
• W3123435912 modified "2023-09-26" @default.
• W3123435912 title "Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways" @default.
• W3123435912 cites W1988760910 @default.
• W3123435912 cites W1999017328 @default.
• W3123435912 cites W2010839828 @default.
• W3123435912 cites W2019426159 @default.
• W3123435912 cites W2019482956 @default.
• W3123435912 cites W2068686351 @default.
• W3123435912 cites W2069996826 @default.
• W3123435912 cites W2092775138 @default.
• W3123435912 cites W2093675879 @default.
• W3123435912 cites W2094199236 @default.
• W3123435912 cites W2100696008 @default.
• W3123435912 cites W2108579114 @default.
• W3123435912 cites W2110408951 @default.
• W3123435912 cites W2112790453 @default.
• W3123435912 cites W2112988722 @default.
• W3123435912 cites W2146559746 @default.
• W3123435912 cites W2149442576 @default.
• W3123435912 cites W2256903816 @default.
• W3123435912 cites W2262045482 @default.
• W3123435912 cites W2400949487 @default.
• W3123435912 cites W2401600644 @default.
• W3123435912 cites W2512054829 @default.
• W3123435912 cites W2546996099 @default.
• W3123435912 cites W2556857248 @default.
• W3123435912 cites W2567066430 @default.
• W3123435912 cites W2579074098 @default.
• W3123435912 cites W2579804224 @default.
• W3123435912 cites W2590861762 @default.
• W3123435912 cites W2592989293 @default.
• W3123435912 cites W2604135869 @default.
• W3123435912 cites W2734588190 @default.
• W3123435912 cites W2748818287 @default.
• W3123435912 cites W2766952249 @default.
• W3123435912 cites W2776389664 @default.
• W3123435912 cites W2786964098 @default.
• W3123435912 cites W2802168264 @default.
• W3123435912 cites W2888358206 @default.
• W3123435912 cites W2902753570 @default.
• W3123435912 cites W2912539413 @default.
• W3123435912 cites W2914744518 @default.
• W3123435912 cites W2914934977 @default.
• W3123435912 cites W2920564902 @default.
• W3123435912 cites W2944872459 @default.
• W3123435912 cites W2946877152 @default.
• W3123435912 cites W2953381346 @default.
• W3123435912 cites W2954420034 @default.
• W3123435912 cites W2968023637 @default.
• W3123435912 cites W2985157200 @default.
• W3123435912 cites W2997836505 @default.
• W3123435912 cites W3003245890 @default.
• W3123435912 cites W3013860552 @default.
• W3123435912 cites W833849825 @default.
• W3123435912 doi "https://doi.org/10.3892/etm.2021.9720" @default.
• W3123435912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7885072" @default.
• W3123435912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33717232" @default.
• W3123435912 hasPublicationYear "2021" @default.
• W3123435912 type Work @default.
• W3123435912 sameAs 3123435912 @default.
• W3123435912 citedByCount "12" @default.
• W3123435912 countsByYear W31234359122022 @default.
• W3123435912 countsByYear W31234359122023 @default.
• W3123435912 crossrefType "journal-article" @default.
• W3123435912 hasAuthorship W3123435912A5004810018 @default.
• W3123435912 hasAuthorship W3123435912A5033707023 @default.
• W3123435912 hasAuthorship W3123435912A5069771802 @default.
• W3123435912 hasAuthorship W3123435912A5087209680 @default.
• W3123435912 hasBestOaLocation W31234359121 @default.
• W3123435912 hasConcept C118131993 @default.
• W3123435912 hasConcept C126322002 @default.
• W3123435912 hasConcept C142724271 @default.
• W3123435912 hasConcept C170493617 @default.
• W3123435912 hasConcept C180361614 @default.
• W3123435912 hasConcept C185592680 @default.
• W3123435912 hasConcept C189165786 @default.
• W3123435912 hasConcept C2775960820 @default.
• W3123435912 hasConcept C2780381497 @default.
• W3123435912 hasConcept C2780559512 @default.
• W3123435912 hasConcept C2781294074 @default.
• W3123435912 hasConcept C502942594 @default.
• W3123435912 hasConcept C54355233 @default.
• W3123435912 hasConcept C55493867 @default.
• W3123435912 hasConcept C57074206 @default.
• W3123435912 hasConcept C62112901 @default.
• W3123435912 hasConcept C62478195 @default.
• W3123435912 hasConcept C71924100 @default.
• W3123435912 hasConcept C81885089 @default.
• W3123435912 hasConcept C86803240 @default.
• W3123435912 hasConcept C95444343 @default.
• W3123435912 hasConceptScore W3123435912C118131993 @default.
• W3123435912 hasConceptScore W3123435912C126322002 @default.
• W3123435912 hasConceptScore W3123435912C142724271 @default.

• next