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- W3123444927 abstract "Electroactive biointerfaces on metallic implants can transduce electrical into ionic signals under exogenous electrical stimulation (ES), which have been proposed to compensate the mislaid bioelectricity signals in bone defects. However, unsatisfied electrical properties and long-term stability are the major issues that hinder their clinical applications. Herein, based on the merits of birnessite-type MnO2 (the large capacitance and effective surface area) and poly(3,4-ethylenedioxythiophene) (PEDOT, the high conductivity and physicochemical stability), MnO2-PEDOT composite nanocoatings (MnO2-P1 and MnO2-P2) were prepared by coating trace amounts of PEDOT onto the MnO2 nanocoating surfaces via an in-situ polymerization method. The composite nanocoatings exhibited decreased charge transfer resistance and concurrently enhanced charge storage capacity. More importantly, the MnO2-P2 nanocoating with thicker PEDOT layer withstood higher voltages with minor loss of mass and charge injection capacity, thus enhancing mechanical and electrochemical stability. The composite nanocoatings were further applied to MC3T3-E1 osteoblastic cells to enhance their adhesion, proliferation and differentiation with the MnO2-P2 showing the greatest enhancement. Enhanced cellular proliferation on the MnO2-P2 nanocoating under ES could be ascribed to the combination of the ES-induced Ca2+-fibronectin interactions and the limited Mn2+ release prevented by PEDOT protective layer." @default.
- W3123444927 created "2021-02-01" @default.
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- W3123444927 date "2021-04-01" @default.
- W3123444927 modified "2023-10-16" @default.
- W3123444927 title "Electroactive MnO2-poly(3,4-ethylenedioxythiophene) composite nanocoatings enhance osteoblastic electrical stimulation" @default.
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- W3123444927 doi "https://doi.org/10.1016/j.apsusc.2020.148827" @default.
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