FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123446607> ?p ?o ?g. }

• W3123446607 endingPage "245" @default.
• W3123446607 startingPage "237" @default.
• W3123446607 abstract "Several genome wide association studies of colorectal cancer (CRC) have identified single nucleotide polymorphisms (SNPs) on chromosome 15q13.3 associated with CRC risk. To identify functional variant(s) underlying this association, we investigated SNPs in linkage disequilibrium with the risk-associated SNP rs4779584 that overlapped regulatory regions/enhancer elements characterized in colon-related tissues and cells. We identified several SNP-containing regulatory regions that exhibited enhancer activity in vitro, including one SNP (rs1406389) that correlated with allele-specific effects on enhancer activity. Deletion of either this enhancer or another enhancer that had previously been reported in this region correlated with decreased expression of GREM1 following CRISPR/Cas9 genome editing. That GREM1 is one target of these enhancers was further supported by an expression quantitative trait loci correlation between rs1406389 and GREM1 expression in the transverse but not sigmoid colon in the Genotype-Tissue Expression dataset. Taken together, we conclude that the 15q13.3 region contains at least two functional variants that map to distinct enhancers and impact CRC risk through modulation of GREM1 expression." @default.
• W3123446607 created "2021-02-01" @default.
• W3123446607 creator A5013835204 @default.
• W3123446607 creator A5017400925 @default.
• W3123446607 creator A5027296062 @default.
• W3123446607 creator A5033227663 @default.
• W3123446607 creator A5073601044 @default.
• W3123446607 creator A5084496654 @default.
• W3123446607 date "2021-02-02" @default.
• W3123446607 modified "2023-10-14" @default.
• W3123446607 title "SNPs associated with colorectal cancer at 15q13.3 affect risk enhancers that modulate <i>GREM1</i> gene expression" @default.
• W3123446607 cites W1504344466 @default.
• W3123446607 cites W1968006026 @default.
• W3123446607 cites W1995773697 @default.
• W3123446607 cites W2001528153 @default.
• W3123446607 cites W2002097988 @default.
• W3123446607 cites W2006519381 @default.
• W3123446607 cites W2010789111 @default.
• W3123446607 cites W2027350554 @default.
• W3123446607 cites W2027873459 @default.
• W3123446607 cites W2042421957 @default.
• W3123446607 cites W2042560956 @default.
• W3123446607 cites W2045459421 @default.
• W3123446607 cites W2048352123 @default.
• W3123446607 cites W2054552261 @default.
• W3123446607 cites W2057398976 @default.
• W3123446607 cites W2064010630 @default.
• W3123446607 cites W2075363163 @default.
• W3123446607 cites W2086838915 @default.
• W3123446607 cites W2095816919 @default.
• W3123446607 cites W2097878546 @default.
• W3123446607 cites W2098259384 @default.
• W3123446607 cites W2099154089 @default.
• W3123446607 cites W2100083515 @default.
• W3123446607 cites W2108490637 @default.
• W3123446607 cites W2116102471 @default.
• W3123446607 cites W2118976071 @default.
• W3123446607 cites W2122039687 @default.
• W3123446607 cites W2124017740 @default.
• W3123446607 cites W2148169621 @default.
• W3123446607 cites W2152626776 @default.
• W3123446607 cites W2156673508 @default.
• W3123446607 cites W2164382475 @default.
• W3123446607 cites W2164752398 @default.
• W3123446607 cites W2259938310 @default.
• W3123446607 cites W2587617032 @default.
• W3123446607 cites W2758092636 @default.
• W3123446607 cites W2761275051 @default.
• W3123446607 cites W2767826728 @default.
• W3123446607 cites W2804783434 @default.
• W3123446607 cites W2808886822 @default.
• W3123446607 cites W2901303766 @default.
• W3123446607 cites W2903533144 @default.
• W3123446607 cites W2943515841 @default.
• W3123446607 cites W2944046200 @default.
• W3123446607 cites W2949294310 @default.
• W3123446607 cites W2980997921 @default.
• W3123446607 cites W3123446607 @default.
• W3123446607 doi "https://doi.org/10.1002/humu.24166" @default.
• W3123446607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7898835" @default.
• W3123446607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33476087" @default.
• W3123446607 hasPublicationYear "2021" @default.
• W3123446607 type Work @default.
• W3123446607 sameAs 3123446607 @default.
• W3123446607 citedByCount "9" @default.
• W3123446607 countsByYear W31234466072021 @default.
• W3123446607 countsByYear W31234466072022 @default.
• W3123446607 countsByYear W31234466072023 @default.
• W3123446607 crossrefType "journal-article" @default.
• W3123446607 hasAuthorship W3123446607A5013835204 @default.
• W3123446607 hasAuthorship W3123446607A5017400925 @default.
• W3123446607 hasAuthorship W3123446607A5027296062 @default.
• W3123446607 hasAuthorship W3123446607A5033227663 @default.
• W3123446607 hasAuthorship W3123446607A5073601044 @default.
• W3123446607 hasAuthorship W3123446607A5084496654 @default.
• W3123446607 hasBestOaLocation W31234466071 @default.
• W3123446607 hasConcept C104317684 @default.
• W3123446607 hasConcept C106208931 @default.
• W3123446607 hasConcept C111936080 @default.
• W3123446607 hasConcept C121608353 @default.
• W3123446607 hasConcept C135763542 @default.
• W3123446607 hasConcept C139275648 @default.
• W3123446607 hasConcept C150194340 @default.
• W3123446607 hasConcept C153209595 @default.
• W3123446607 hasConcept C168393362 @default.
• W3123446607 hasConcept C180754005 @default.
• W3123446607 hasConcept C186413461 @default.
• W3123446607 hasConcept C35605836 @default.
• W3123446607 hasConcept C526805850 @default.
• W3123446607 hasConcept C54355233 @default.
• W3123446607 hasConcept C86803240 @default.
• W3123446607 hasConceptScore W3123446607C104317684 @default.
• W3123446607 hasConceptScore W3123446607C106208931 @default.
• W3123446607 hasConceptScore W3123446607C111936080 @default.
• W3123446607 hasConceptScore W3123446607C121608353 @default.
• W3123446607 hasConceptScore W3123446607C135763542 @default.
• W3123446607 hasConceptScore W3123446607C139275648 @default.
• W3123446607 hasConceptScore W3123446607C150194340 @default.

• next