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- W3123456084 endingPage "189" @default.
- W3123456084 startingPage "189" @default.
- W3123456084 abstract "The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development and progression both in solid cancers and hematological malignancies. The human P2X7 gene is highly polymorphic, and several splice variants of the receptor have been identified in time. P2X7 single-nucleotide polymorphisms (SNPs) have been broadly analyzed by studies relating them to pathologies as different as infectious, inflammatory, nervous, and bone diseases, among which cancer is included. Moreover, in the last years, an increasing number of reports concentrated on P2X7 splice variants’ different roles and their implications in pathological conditions, including oncogenesis. Here, we give an overview of established and recent literature demonstrating a role for human P2X7 gene products in oncological conditions, mainly focusing on current data emerging on P2X7 isoform B and nfP2X7. We explored the role of these and other genetic variants of P2X7 in cancer insurgence, dissemination, and progression, as well as the effect of chemotherapy on isoforms expression. The described literature strongly suggests that P2X7 variants are potential new biomarkers and therapeutical targets in oncological conditions and that their study in carcinogenesis deserves to be further pursued." @default.
- W3123456084 created "2021-02-01" @default.
- W3123456084 creator A5053938706 @default.
- W3123456084 creator A5074345267 @default.
- W3123456084 creator A5076910866 @default.
- W3123456084 date "2021-01-19" @default.
- W3123456084 modified "2023-10-16" @default.
- W3123456084 title "P2X7 Variants in Oncogenesis" @default.
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