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• W3123508728 abstract "The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern. Critically, these global priority bacteria have begun to be reported in companion animals, implying a potential risk of cross-transmission between humans and pets. Using long-read (MinION) and short-read (Illumina) sequencing technologies, we have identified and characterized a hypermucoviscous KPC-2-producing Klebsiella pneumoniae strain belonging to the high-risk international clone ST11/CG258, in a dog with urinary tract infection. Strikingly, the blaKPC-2 gene was carried by a 54-kb IncN plasmid assignated to ST15, which shared 99.8 and 96.8% pairwise identity with IncN-pST15 plasmids from human and environmental K. pneumoniae strains, respectively; all come from an area with high endemicity of KPC-2. Our findings suggest that IncN-pST15 plasmids conferring carbapenem resistance can play as important a role as clonal transmission of K. pneumoniae, representing another major challenge for One Health." @default.
• W3123508728 created "2021-02-01" @default.
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• W3123508728 date "2021-02-21" @default.
• W3123508728 modified "2023-10-18" @default.
• W3123508728 title "Detection of IncN‐pST15 one‐health plasmid harbouring <i>bla</i> _KPC‐2 in a hypermucoviscous <i>Klebsiella pneumoniae</i> CG258 isolated from an infected dog, Brazil" @default.
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• W3123508728 doi "https://doi.org/10.1111/tbed.14006" @default.
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