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- W3123628426 abstract "Objective: To establish a spectrophotometric method for terfenadine determination based on charge-transfer reaction. Methods: The 1∶ 1 charge-transfer complex was prepared in water solution by charge-transfer reaction when terfenadine and alizarin red took place,and determined at the complex maximum absorption wavelength of 522 nm. Then,the content of terfenadine was calculated. Results: The linear range of the content was 3. 0-72. 0 μg·m L- 1,and the correlation coefficient was 0. 998 2. The detection limit for this method was 0. 87 μg·m L- 1,and RSD of precision was 1. 5%. The apparent molar absorptivity of complex was 5. 424 × 103L·mol- 1·cm- 1. The established method has been applied to the terfenadine determination in tablets and capsules. The results were in consistent with the data obtained by the pharmacopeia method. The recoveries were 98. 6% for the tablets and 101. 3% for the capsules. Conclusion: The established method is accurate and with good repeatability,which can be applied to the analysis of terfenadine in tablets and capsules." @default.
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- W3123628426 date "2015-01-01" @default.
- W3123628426 modified "2023-09-23" @default.
- W3123628426 title "Spectrophotometric determination of terfenadine based on charge-transfer reaction with alizarin red" @default.
- W3123628426 hasPublicationYear "2015" @default.
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