Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123641106> ?p ?o ?g. }
- W3123641106 abstract "Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed." @default.
- W3123641106 created "2021-02-01" @default.
- W3123641106 creator A5014377000 @default.
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- W3123641106 creator A5053959355 @default.
- W3123641106 creator A5061472855 @default.
- W3123641106 creator A5071798264 @default.
- W3123641106 creator A5086875518 @default.
- W3123641106 date "2021-01-26" @default.
- W3123641106 modified "2023-10-15" @default.
- W3123641106 title "Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease" @default.
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