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• W3123652669 endingPage "100924" @default.
• W3123652669 startingPage "100924" @default.
• W3123652669 abstract "Adversity early in life substantially impacts prefrontal cortex (PFC) development and vulnerability to later-life psychopathology. Importantly, repeated adverse experiences throughout childhood increase the risk for PFC-mediated behavioral deficits more commonly in women. Evidence from animal models points to effects of adversity on later-life neural and behavioral dysfunction; however, few studies have investigated the neurobiological underpinnings of sex-specific, long-term consequences of multiple developmental stressors. We modeled early life adversity in rats via maternal separation (postnatal day (P)2-20) and juvenile social isolation (P21-35). In adulthood, anxiety-like behavior was assessed in the elevated zero maze and the presence and structural integrity of PFC perineuronal nets (PNNs) enwrapping parvalbumin (PV)-expressing interneurons was quantified. PNNs are extracellular matrix structures formed during critical periods in postnatal development that play a key role in the plasticity of PV cells. We observed a female-specific effect of adversity on hyperactivity and risk-assessment behavior. Moreover, females – but not males – exposed to multiple hits of adversity demonstrated a reduction in PFC PV cells in adulthood. We also observed a sex-specific, potentiated reduction in PV + PNN structural integrity. These findings suggest a sex-specific impact of repeated adversity on neurostructural development and implicate PNNs as a contributor to associated behavioral dysfunction." @default.
• W3123652669 created "2021-02-01" @default.
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• W3123652669 date "2021-04-01" @default.
• W3123652669 modified "2023-09-26" @default.
• W3123652669 title "A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior" @default.
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• W3123652669 doi "https://doi.org/10.1016/j.dcn.2021.100924" @default.
• W3123652669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7847967" @default.
• W3123652669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33515957" @default.
• W3123652669 hasPublicationYear "2021" @default.

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