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- W3123659059 abstract "Abstract The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex." @default.
- W3123659059 created "2021-02-01" @default.
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- W3123659059 date "2021-03-01" @default.
- W3123659059 modified "2023-10-16" @default.
- W3123659059 title "Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex" @default.
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- W3123659059 doi "https://doi.org/10.1016/j.bmcl.2021.127824" @default.
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