FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3123661549> ?p ?o ?g. }

• W3123661549 endingPage "10" @default.
• W3123661549 startingPage "3" @default.
• W3123661549 abstract "To test that the osteogenic capacity of periodontal ligament (PDL) fibroblasts can be mediated by TLR2 and TLR4 activation.Human PDL fibroblasts were cultured in osteogenic medium and treated with TLR2 and TLR4 agonists (Pam3CSK4 and monophosphoryl Lipid A (MPLA), respectively). Cell proliferation was measured by MTT and BrdU incorporation. Osteogenic differentiation was measured by alkaline phosphatase (ALP) activity. Nodule formation was measured for osteoblast function. The expression of markers of potential signaling pathways (RUNX2, OCN, BSP and Osterix) was evaluated by quantitative PCR.PDL fibroblasts grew at the same rate during the first 5 days in response to both Pam3CSK5 and MPLA. On day 7, cells cultured in the presence of Pam3CSK4 had a significantly higher rate of DNA replication, while cells in MPLA group had a significantly lower DNA replication rate (one-third) compared to the control (p less than 0.05). Pam3CSK4 induced significantly higher ALP activity and larger calcified nodules. TLR4 activation significantly reduced the expression of RUNX2 and osterix and enhanced OCN. Neither TLR2 nor TLR4 affected BSP expression.These data suggest that the activation of TLR2 and TLR4 differentially and perhaps antagonistically modulate osteogenesis by human PDL fibroblasts and have a direct role of TLR-mediated PDL function during periodontal regeneration as a potential target for therapeutics." @default.
• W3123661549 created "2021-02-01" @default.
• W3123661549 creator A5014230085 @default.
• W3123661549 creator A5018515481 @default.
• W3123661549 creator A5021437697 @default.
• W3123661549 creator A5028344929 @default.
• W3123661549 creator A5052746469 @default.
• W3123661549 creator A5091330893 @default.
• W3123661549 date "2021-01-01" @default.
• W3123661549 modified "2023-09-23" @default.
• W3123661549 title "TLR2 and TLR4 Differentially Regulate the Osteogenic Capacity of Human Periodontal Ligament Fibroblasts." @default.
• W3123661549 cites W1655860314 @default.
• W3123661549 cites W1902854090 @default.
• W3123661549 cites W1970190964 @default.
• W3123661549 cites W1972494459 @default.
• W3123661549 cites W1975166559 @default.
• W3123661549 cites W1976571762 @default.
• W3123661549 cites W1979743972 @default.
• W3123661549 cites W1991585565 @default.
• W3123661549 cites W1992415952 @default.
• W3123661549 cites W1996333219 @default.
• W3123661549 cites W1996466245 @default.
• W3123661549 cites W2003043071 @default.
• W3123661549 cites W2015050458 @default.
• W3123661549 cites W2019848731 @default.
• W3123661549 cites W2027219830 @default.
• W3123661549 cites W2049437688 @default.
• W3123661549 cites W2050385053 @default.
• W3123661549 cites W2062086916 @default.
• W3123661549 cites W2111971681 @default.
• W3123661549 cites W2113759342 @default.
• W3123661549 cites W2114528551 @default.
• W3123661549 cites W2159321615 @default.
• W3123661549 cites W2163638806 @default.
• W3123661549 cites W2169804428 @default.
• W3123661549 cites W2217100198 @default.
• W3123661549 cites W2317279002 @default.
• W3123661549 cites W2347069914 @default.
• W3123661549 cites W2749635740 @default.
• W3123661549 cites W2950266491 @default.
• W3123661549 cites W4255289084 @default.
• W3123661549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8142849" @default.
• W3123661549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33512337" @default.
• W3123661549 hasPublicationYear "2021" @default.
• W3123661549 type Work @default.
• W3123661549 sameAs 3123661549 @default.
• W3123661549 citedByCount "1" @default.
• W3123661549 countsByYear W31236615492022 @default.
• W3123661549 crossrefType "journal-article" @default.
• W3123661549 hasAuthorship W3123661549A5014230085 @default.
• W3123661549 hasAuthorship W3123661549A5018515481 @default.
• W3123661549 hasAuthorship W3123661549A5021437697 @default.
• W3123661549 hasAuthorship W3123661549A5028344929 @default.
• W3123661549 hasAuthorship W3123661549A5052746469 @default.
• W3123661549 hasAuthorship W3123661549A5091330893 @default.
• W3123661549 hasConcept C153911025 @default.
• W3123661549 hasConcept C160160445 @default.
• W3123661549 hasConcept C171056886 @default.
• W3123661549 hasConcept C181199279 @default.
• W3123661549 hasConcept C185592680 @default.
• W3123661549 hasConcept C199343813 @default.
• W3123661549 hasConcept C202751555 @default.
• W3123661549 hasConcept C2776070231 @default.
• W3123661549 hasConcept C2776363554 @default.
• W3123661549 hasConcept C2778260815 @default.
• W3123661549 hasConcept C2781236682 @default.
• W3123661549 hasConcept C41868710 @default.
• W3123661549 hasConcept C55493867 @default.
• W3123661549 hasConcept C62478195 @default.
• W3123661549 hasConcept C71924100 @default.
• W3123661549 hasConcept C86803240 @default.
• W3123661549 hasConcept C95444343 @default.
• W3123661549 hasConceptScore W3123661549C153911025 @default.
• W3123661549 hasConceptScore W3123661549C160160445 @default.
• W3123661549 hasConceptScore W3123661549C171056886 @default.
• W3123661549 hasConceptScore W3123661549C181199279 @default.
• W3123661549 hasConceptScore W3123661549C185592680 @default.
• W3123661549 hasConceptScore W3123661549C199343813 @default.
• W3123661549 hasConceptScore W3123661549C202751555 @default.
• W3123661549 hasConceptScore W3123661549C2776070231 @default.
• W3123661549 hasConceptScore W3123661549C2776363554 @default.
• W3123661549 hasConceptScore W3123661549C2778260815 @default.
• W3123661549 hasConceptScore W3123661549C2781236682 @default.
• W3123661549 hasConceptScore W3123661549C41868710 @default.
• W3123661549 hasConceptScore W3123661549C55493867 @default.
• W3123661549 hasConceptScore W3123661549C62478195 @default.
• W3123661549 hasConceptScore W3123661549C71924100 @default.
• W3123661549 hasConceptScore W3123661549C86803240 @default.
• W3123661549 hasConceptScore W3123661549C95444343 @default.
• W3123661549 hasIssue "1" @default.
• W3123661549 hasLocation W31236615491 @default.
• W3123661549 hasOpenAccess W3123661549 @default.
• W3123661549 hasPrimaryLocation W31236615491 @default.
• W3123661549 hasRelatedWork W12815476 @default.
• W3123661549 hasRelatedWork W20748828 @default.
• W3123661549 hasRelatedWork W2226909 @default.
• W3123661549 hasRelatedWork W23043966 @default.
• W3123661549 hasRelatedWork W23563578 @default.

• next