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• W3123674369 abstract "The current study aims to evaluate the ameliorative effect of polydatin-loaded-chitosan nanoparticles (PD-CSNPs), polydatin (PD), and metformin on Diabetes-induced pulmonary disorders. After induction of diabetes, rats are classified into five groups, diabetic control and diabetic rats treated daily for four weeks with; PD, PD-CSNPs, chitosan-nanoparticles and metformin. Rats treated with PD and PD-CSNPs showed a reduction in glycosylated-haemoglobin % and lipid peroxidation level, increased activities of superoxide peroxidase, superoxide dismutase and catalase, and glutathione content in treated diabetic rats lung. Furthermore, PD-CSNPs, PD and MET decreased tumour necrosis factor-alpha and nuclear factor-kappa-β and upregulated nuclear factor erythroid 2-related factor-2 and haem oxygenase-1. Histological and ultrastructural examinations revealed their ameliorative effect via reducing the bronchiolar and alveolar fibrosis, thickening of the interalveolar septum, and inflammatory cell infiltration. In conclusion, PD-CSNPs was more effective than MET and PD in improvement the diabetes-induced pulmonary disorders through its antioxidant, anti-inflammatory, and prolonged-release properties." @default.
• W3123674369 created "2021-02-01" @default.
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• W3123674369 date "2021-01-01" @default.
• W3123674369 modified "2023-10-12" @default.
• W3123674369 title "Ameliorative effect of polydatin and polydatin-loaded chitosan nanoparticles against diabetes-induced pulmonary disorders in rats" @default.
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• W3123674369 doi "https://doi.org/10.1080/16583655.2020.1860504" @default.
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