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- W3123758215 abstract "Antimicrobial resistance is a global public health concern, and resistance genes in Salmonella, especially those located on mobile genetic elements, are part of the problem. This study used phenotypic and genomic methods to identify antimicrobial resistance and resistance genes, as well as the plasmids that bear them, in Salmonella isolates obtained from poultry in Nigeria. Seventy-four isolates were tested for susceptibility to eleven commonly used antimicrobials. Plasmid reconstruction and identification of resistance and virulence genes were performed with a draft genome using in silico approaches in parallel with plasmid extraction. Phenotypic resistance to ciprofloxacin (50.0%), gentamicin (48.6%), nalidixic acid (79.7%), sulphonamides (71.6%) and tetracycline (59.5%) was the most observed. Antibiotic resistance genes (ARGs) detected in genomes corresponded well with these observations. Commonly observed ARGs included sul1, sul2, sul3, tet (A), tet (M), qnrS1, qnrB19 and a variety of aminoglycoside-modifying genes, in addition to point mutations in the gyrA and parC genes. Multiple ARGs were predicted to be located on IncN and IncQ1 plasmids of S. Schwarzengrund and S. Muenster, and most qnrB19 genes were carried by Col (pHAD28) plasmids. Seventy-two percent (19/24) of S. Kentucky strains carried multidrug ARGs located in two distinct variants of Salmonella genomic island I. The majority of strains carried full SPI-1 and SPI-2 islands, suggesting full virulence potential." @default.
- W3123758215 created "2021-02-01" @default.
- W3123758215 creator A5027478593 @default.
- W3123758215 creator A5033274681 @default.
- W3123758215 creator A5064698808 @default.
- W3123758215 creator A5068160600 @default.
- W3123758215 date "2021-01-20" @default.
- W3123758215 modified "2023-10-16" @default.
- W3123758215 title "Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria" @default.
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- W3123758215 doi "https://doi.org/10.3390/antibiotics10020099" @default.
- W3123758215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7909428" @default.
- W3123758215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33498344" @default.
- W3123758215 hasPublicationYear "2021" @default.
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