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- W3123765439 abstract "Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval Drosophila We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a Drosophila α1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit." @default.
- W3123765439 created "2021-02-01" @default.
- W3123765439 creator A5000079161 @default.
- W3123765439 creator A5006364272 @default.
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- W3123765439 creator A5079227015 @default.
- W3123765439 creator A5084697552 @default.
- W3123765439 creator A5089747405 @default.
- W3123765439 date "2021-01-15" @default.
- W3123765439 modified "2023-10-17" @default.
- W3123765439 title "Octopaminergic neurons have multiple targets in <i>Drosophila</i> larval mushroom body calyx and can modulate behavioral odor discrimination" @default.
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