Matches in SemOpenAlex for { <https://semopenalex.org/work/W31238345> ?p ?o ?g. }
- W31238345 abstract "As a ubiquitous intracellular messenger ion, calcium is involved in many critical biochemical processes in the cell. In cardiomyocytes, Ca interacts with a variety of calcium-sensing proteins and regulates cardiac pacemaking, excitability and contractility. This study examined two typical calcium-sensing proteins: calpain and Ca/calmodulindependent protein kinase II (CaMKII). Drosophila melanogaster was used as a model to explore the roles of these proteins in cardiomyocyte and how their dysregulation affects cardiac function. We show here that calpain mutations, calpain knockdowns, and CaMKII knockdown result in increased cardiac frequency and rhythmicity. In contrast, mutation in CaMKII causes a decreased cardiac frequency and rhythmicity. The findings deepened our understanding of the roles of calpain and CaMKII in heart cells and how their dysregulation could affect the heartbeat." @default.
- W31238345 created "2016-06-24" @default.
- W31238345 creator A5022355646 @default.
- W31238345 date "2014-01-01" @default.
- W31238345 modified "2023-09-27" @default.
- W31238345 title "Effects of Calcium-Sensing Protein Dysregulation on Cardiac Function in Drosophila melanogaster" @default.
- W31238345 cites W1483489359 @default.
- W31238345 cites W1587564193 @default.
- W31238345 cites W1654410153 @default.
- W31238345 cites W1964152667 @default.
- W31238345 cites W1964706412 @default.
- W31238345 cites W1976819248 @default.
- W31238345 cites W1989679097 @default.
- W31238345 cites W1993900486 @default.
- W31238345 cites W1997265358 @default.
- W31238345 cites W2001049607 @default.
- W31238345 cites W2003552474 @default.
- W31238345 cites W2003607907 @default.
- W31238345 cites W2016448886 @default.
- W31238345 cites W2021242075 @default.
- W31238345 cites W2023165472 @default.
- W31238345 cites W2023309134 @default.
- W31238345 cites W2023591835 @default.
- W31238345 cites W2029853313 @default.
- W31238345 cites W2041330970 @default.
- W31238345 cites W2044302872 @default.
- W31238345 cites W2050824263 @default.
- W31238345 cites W2057491896 @default.
- W31238345 cites W2067275294 @default.
- W31238345 cites W2082291205 @default.
- W31238345 cites W2090802617 @default.
- W31238345 cites W2100270425 @default.
- W31238345 cites W2110659224 @default.
- W31238345 cites W2115707237 @default.
- W31238345 cites W2116691755 @default.
- W31238345 cites W2116988718 @default.
- W31238345 cites W2125780660 @default.
- W31238345 cites W2126455177 @default.
- W31238345 cites W2131802378 @default.
- W31238345 cites W2132930716 @default.
- W31238345 cites W2135539659 @default.
- W31238345 cites W2135846312 @default.
- W31238345 cites W2141652419 @default.
- W31238345 cites W2159453909 @default.
- W31238345 cites W2168269637 @default.
- W31238345 cites W2169436026 @default.
- W31238345 cites W2345055725 @default.
- W31238345 cites W2503615964 @default.
- W31238345 cites W2616563136 @default.
- W31238345 cites W2912072485 @default.
- W31238345 cites W2916774960 @default.
- W31238345 cites W563750707 @default.
- W31238345 hasPublicationYear "2014" @default.
- W31238345 type Work @default.
- W31238345 sameAs 31238345 @default.
- W31238345 citedByCount "0" @default.
- W31238345 crossrefType "journal-article" @default.
- W31238345 hasAuthorship W31238345A5022355646 @default.
- W31238345 hasConcept C104317684 @default.
- W31238345 hasConcept C126322002 @default.
- W31238345 hasConcept C134018914 @default.
- W31238345 hasConcept C13852961 @default.
- W31238345 hasConcept C163235415 @default.
- W31238345 hasConcept C173396325 @default.
- W31238345 hasConcept C181080969 @default.
- W31238345 hasConcept C181199279 @default.
- W31238345 hasConcept C184235292 @default.
- W31238345 hasConcept C201571599 @default.
- W31238345 hasConcept C2780104201 @default.
- W31238345 hasConcept C38652104 @default.
- W31238345 hasConcept C39133596 @default.
- W31238345 hasConcept C41008148 @default.
- W31238345 hasConcept C501734568 @default.
- W31238345 hasConcept C519063684 @default.
- W31238345 hasConcept C54355233 @default.
- W31238345 hasConcept C55493867 @default.
- W31238345 hasConcept C56928146 @default.
- W31238345 hasConcept C71924100 @default.
- W31238345 hasConcept C79879829 @default.
- W31238345 hasConcept C86803240 @default.
- W31238345 hasConcept C95444343 @default.
- W31238345 hasConcept C97029542 @default.
- W31238345 hasConceptScore W31238345C104317684 @default.
- W31238345 hasConceptScore W31238345C126322002 @default.
- W31238345 hasConceptScore W31238345C134018914 @default.
- W31238345 hasConceptScore W31238345C13852961 @default.
- W31238345 hasConceptScore W31238345C163235415 @default.
- W31238345 hasConceptScore W31238345C173396325 @default.
- W31238345 hasConceptScore W31238345C181080969 @default.
- W31238345 hasConceptScore W31238345C181199279 @default.
- W31238345 hasConceptScore W31238345C184235292 @default.
- W31238345 hasConceptScore W31238345C201571599 @default.
- W31238345 hasConceptScore W31238345C2780104201 @default.
- W31238345 hasConceptScore W31238345C38652104 @default.
- W31238345 hasConceptScore W31238345C39133596 @default.
- W31238345 hasConceptScore W31238345C41008148 @default.
- W31238345 hasConceptScore W31238345C501734568 @default.
- W31238345 hasConceptScore W31238345C519063684 @default.
- W31238345 hasConceptScore W31238345C54355233 @default.
- W31238345 hasConceptScore W31238345C55493867 @default.