FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124008081> ?p ?o ?g. }

• W3124008081 abstract "Early-life neglect in critical developmental periods has been associated with emotional and cognitive consequences. Maternal separation (MS) has been commonly used as a rodent model to identify the developmental effects of child neglect. However, reports have shown considerable variability in behavioral results from MS studies in both mice and rats. Difficulties in developing reliable child neglect models have impeded advances in identifying the effects of early-life stress. Accumulating evidence shows that neuronal intrinsic excitability plays an important role in information processing and storage in the brain. The prefrontal cortex (PFC) integrates information from many cortical and subcortical structures. No studies to date have examined the impact of early-life stress on glutamatergic neuronal excitability in the PFC. This study aimed to develop a reliable child neglect rat model and observe glutamatergic neuronal excitability in the PFC. An MS with early weaning (MSEW) rat model was developed. Rats were separated from the dam for 4 h per day on postnatal days (PNDs) 2–5 and for 8 h per day on PNDs 6–16 and then weaned on PND 17. A battery of behavioral tests was used to assess anxiety-like behavior, coping behavior, working memory, spatial reference memory, and fear memory. The action potentials (APs) of glutamatergic neuronal membranes were recorded. MSEW resulted in anxiety-like behavior, a passive coping strategy and increased fear memory in male rats and decreased locomotor activity in both sexes. MSEW slightly impaired working memory during non-stressful situations in female rats but did not change spatial reference memory or associative learning under stressful circumstances in either sex. MSEW reduced the number of glutamatergic neuron APs in male rats. Our findings showed that MS with early weaning induced anxiety-like behavior in male rats. The reduced glutamatergic neuronal excitability may be associated with the emotional alteration induced by MSEW in male rats. In addition, MSEW induced adaptive modification, which depended on a non-stressful context." @default.
• W3124008081 created "2021-02-01" @default.
• W3124008081 creator A5020377193 @default.
• W3124008081 creator A5040709374 @default.
• W3124008081 creator A5050574477 @default.
• W3124008081 creator A5057788539 @default.
• W3124008081 creator A5078576975 @default.
• W3124008081 date "2021-01-26" @default.
• W3124008081 modified "2023-10-16" @default.
• W3124008081 title "Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex" @default.
• W3124008081 cites W1585420472 @default.
• W3124008081 cites W1903965668 @default.
• W3124008081 cites W1965773704 @default.
• W3124008081 cites W1966037459 @default.
• W3124008081 cites W1977029849 @default.
• W3124008081 cites W2008301991 @default.
• W3124008081 cites W2037070770 @default.
• W3124008081 cites W2044364684 @default.
• W3124008081 cites W2048503594 @default.
• W3124008081 cites W2052440064 @default.
• W3124008081 cites W2054649184 @default.
• W3124008081 cites W2066295027 @default.
• W3124008081 cites W2068163081 @default.
• W3124008081 cites W2070173588 @default.
• W3124008081 cites W2077269712 @default.
• W3124008081 cites W2079464767 @default.
• W3124008081 cites W2104419150 @default.
• W3124008081 cites W2127169747 @default.
• W3124008081 cites W2135468643 @default.
• W3124008081 cites W2135562556 @default.
• W3124008081 cites W2136906274 @default.
• W3124008081 cites W2153988504 @default.
• W3124008081 cites W2271686560 @default.
• W3124008081 cites W2282523187 @default.
• W3124008081 cites W2529339498 @default.
• W3124008081 cites W2556751720 @default.
• W3124008081 cites W2570038129 @default.
• W3124008081 cites W2586171856 @default.
• W3124008081 cites W2753237181 @default.
• W3124008081 cites W2763303457 @default.
• W3124008081 cites W2768172955 @default.
• W3124008081 cites W2776321968 @default.
• W3124008081 cites W2785413961 @default.
• W3124008081 cites W2790434348 @default.
• W3124008081 cites W2791189429 @default.
• W3124008081 cites W2800603098 @default.
• W3124008081 cites W2807980645 @default.
• W3124008081 cites W2810146004 @default.
• W3124008081 cites W2853214301 @default.
• W3124008081 cites W2883388010 @default.
• W3124008081 cites W2889842063 @default.
• W3124008081 cites W289503551 @default.
• W3124008081 cites W2902079119 @default.
• W3124008081 cites W2905210080 @default.
• W3124008081 cites W2908446636 @default.
• W3124008081 cites W2910649779 @default.
• W3124008081 cites W2910838753 @default.
• W3124008081 cites W2921510018 @default.
• W3124008081 cites W2939293709 @default.
• W3124008081 cites W2943859684 @default.
• W3124008081 cites W2952704221 @default.
• W3124008081 cites W2953025968 @default.
• W3124008081 cites W2969901945 @default.
• W3124008081 cites W2971949693 @default.
• W3124008081 cites W2972595417 @default.
• W3124008081 cites W3007569487 @default.
• W3124008081 cites W3029442986 @default.
• W3124008081 cites W4213346165 @default.
• W3124008081 doi "https://doi.org/10.3389/fpsyt.2020.572224" @default.
• W3124008081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7870800" @default.
• W3124008081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33574771" @default.
• W3124008081 hasPublicationYear "2021" @default.
• W3124008081 type Work @default.
• W3124008081 sameAs 3124008081 @default.
• W3124008081 citedByCount "11" @default.
• W3124008081 countsByYear W31240080812021 @default.
• W3124008081 countsByYear W31240080812022 @default.
• W3124008081 countsByYear W31240080812023 @default.
• W3124008081 crossrefType "journal-article" @default.
• W3124008081 hasAuthorship W3124008081A5020377193 @default.
• W3124008081 hasAuthorship W3124008081A5040709374 @default.
• W3124008081 hasAuthorship W3124008081A5050574477 @default.
• W3124008081 hasAuthorship W3124008081A5057788539 @default.
• W3124008081 hasAuthorship W3124008081A5078576975 @default.
• W3124008081 hasBestOaLocation W31240080811 @default.
• W3124008081 hasConcept C118552586 @default.
• W3124008081 hasConcept C126322002 @default.
• W3124008081 hasConcept C15744967 @default.
• W3124008081 hasConcept C169760540 @default.
• W3124008081 hasConcept C169900460 @default.
• W3124008081 hasConcept C170493617 @default.
• W3124008081 hasConcept C21963081 @default.
• W3124008081 hasConcept C2776289891 @default.
• W3124008081 hasConcept C2780648746 @default.
• W3124008081 hasConcept C2781195155 @default.
• W3124008081 hasConcept C558461103 @default.
• W3124008081 hasConcept C61174792 @default.
• W3124008081 hasConcept C71924100 @default.
• W3124008081 hasConceptScore W3124008081C118552586 @default.
• W3124008081 hasConceptScore W3124008081C126322002 @default.

• next