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• W3124018425 abstract "To investigate the influence of different procedures of testicular sperm retrieval on the levels of serum inhibin B (INHB), antisperm antibodies (AsAb), follicle-stimulating hormone (FSH), and testosterone (T) in patients with azoospermia.We randomly assigned 210 azoospermia patients to receive testicular sperm extraction (TESE, n = 50), testicular sperm aspiration (TESA, n = 56), testicular fine needle aspiration (TEFNA, n = 64), or microscopic TESE (micro-TESE, n = 40). We measured the levels of serum INHB, FSH, and T and the positive rate of AsAb before and at 1 and 3 months after surgery.Compared with the baseline, the levels of serum FSH at 1 and 3 months after surgery showed no statistically significant differences in the TESE (［8.51 ± 4.34］ vs ［8.76 ± 3.07］ and ［7.24 ± 3.32］ IU/L, P >0.05), TESA (［7.70 ± 2.72］ vs ［7.90 ± 4.57］ and ［8.04 ± 3.65］ IU/L, P >0.05), TEFNA (［6.04 ± 3.17］ vs ［6.08 ± 2.70］ and ［6.10 ± 3.32］ IU/L, P >0.05), or micro-TESE group (［6.59 ± 2.74］ vs ［6.89 ± 1.78］ and ［6.75 ± 2.57］ IU/L, P >0.05); the positive rate of AsAb (IgM) was significantly increased at 1 month in the TESE (0.00 vs 14.00%, P <0.05) and micro-TESE groups (2.50% vs 15.00%, P <0.05), while the serum T level markedly decreased in the two groups (［16.52 ± 6.25］ vs ［9.25 ± 5.76］ nmol/L and ［14.16 ± 5.45］ vs ［8.23 ± 4.12］ nmol/L, P <0.05); the levels of serum INHB were remarkably reduced at 1 and 3 months in the TESE (［70.56 ± 23.17］ vs ［42.63 ± 15.34］ and ［44.05 ± 18.47］ pg/ml, P <0.05), TESA (［68.71 ± 14.74］ vs ［40.55 ± 20.51］ and ［42.11 ± 19.34］ pg/ml, P <0.05), TEFNA (［76.81 ± 27.04］ vs ［46.31 ± 19.28］ and ［48.32 ± 20.54］ pg/ml, P <0.05), and micro-TESE groups (［74.74 ± 28.35］ vs ［45.27 ± 18.83］ and ［47.64 ± 28.34］ pg/ml, P <0.05), but with no statistically significant differences among the four groups (P >0.05).Different procedures of testicular sperm retrieval have different impacts on the testicular function and AsAb in patients with azoospermia.目的： 研究不同睾丸活检术对无精子症患者血清抑制素B(INHB)、血清抗精子抗体(AsAb)、卵泡刺激素(FSH)、睾酮(T)的影响。方法： 选取无精子症患者210例，根据不同的睾丸活检手术方式，分为睾丸切开活检取精术(TESE)组50例、睾丸穿刺抽吸取精术(TESA)组56例、睾丸细针穿刺抽吸取精术(TEFNA)组64例、显微睾丸切开取精术(micro-TESE)组40例，分别检测睾丸活检术前及术后1、3个月患者血清INHB、FSH、T水平和AsAb阳性率。结果： 4组患者术后1、3个月FSH与术前比较均无显著性差异［TESE：（8.76±3.07）IU/L、（7.24±3.32）IU/L vs （8.51±4.34）IU/L； TESA：（7.90±4.57）IU/L、（8.04±3.65）IU/L vs （7.70±2.72）IU/L；TEFNA：（6.08±2.70）IU/L、（6.10±3.32）IU/L vs （6.04±3.17）IU/L；micro-TESE：（6.89±1.78）IU/L、（6.75±2.57）IU/L vs （6.59±2.74）IU/L ，P均>0.05］。TESE组和micro-TESE组术后1个月AsAb IgM阳性率（14.00%和15.00%）较术前（0.00和2.50%）明显升高（P<0.05）。TESE组和micro-TESE组患者术后1个月T水平［（9.25±5.76）nmol/L和（8.23±4.12）nmol/L］较术前［（16.52±6.25）nmol/L和（14.16±5.45）nmol/L］明显下降（P均<0.05）。TESE、TESA、TEFNA、micro-TESE4组患者术后1、3个月血清INHB较术前均明显下降［TESE：（42.63±15.34）pg/ml、（44.05±18.47）pg/ml vs （70.56±23.17）pg/ml； TESA：（40.55±20.51）pg/ml、（42.11±19.34）pg/ml vs （68.71±14.74）pg/ml；TEFNA：（46.31±19.28）pg/ml、（48.32±20.54）pg/ml vs （76.81±27.04）pg/ml；micro-TESE：（45.27±18.83）pg/ml、（47.64±28.34）pg/ml vs （74.74±28.35）pg/ml，P均<0.05］，但不同方法组组间无统计学差异（P>0.05）。结论： 不同睾丸活检术对无精子症患者睾丸功能及AsAb有影响，且存在一定差异。." @default.
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• W3124018425 date "2017-07-01" @default.
• W3124018425 modified "2023-09-23" @default.
• W3124018425 title "[Impacts of different procedures of testicular sperm retrieval on testicular function and antisperm antibodies in azoospermia patients]." @default.
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