FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124084304> ?p ?o ?g. }

• W3124084304 endingPage "579" @default.
• W3124084304 startingPage "568" @default.
• W3124084304 abstract "The success of drug development of targeted therapy often hinges on an appropriate selection of the sensitive patient population, mostly based on patients’ biomarker levels. At the planning stage of a Phase II study, although a potential biomarker may have been identified, a threshold value for defining sensitive patient population is often unavailable for adopting many existing biomarker-guided designs. To address this issue, we propose a two-stage design that allows for simultaneous biomarker threshold selection and efficacy evaluation while accommodating situations where the drug is efficacious in the entire patient population. The design uses a Bayesian decision-theoretic approach and incorporates the benefit and cost considerations of the study into a utility function. The operating characteristics of the proposed design under different scenarios are investigated via simulations. We also provide a discussion on the choice of the benefit and cost parameters in practice." @default.
• W3124084304 created "2021-02-01" @default.
• W3124084304 creator A5007801126 @default.
• W3124084304 creator A5008032475 @default.
• W3124084304 creator A5021087933 @default.
• W3124084304 creator A5027127519 @default.
• W3124084304 creator A5032073558 @default.
• W3124084304 creator A5037049857 @default.
• W3124084304 creator A5057857378 @default.
• W3124084304 creator A5080102032 @default.
• W3124084304 date "2021-02-09" @default.
• W3124084304 modified "2023-09-27" @default.
• W3124084304 title "A Bayesian Decision-Theoretic Design for Simultaneous Biomarker-Based Subgroup Selection and Efficacy Evaluation" @default.
• W3124084304 cites W1553321206 @default.
• W3124084304 cites W1595208032 @default.
• W3124084304 cites W1917337005 @default.
• W3124084304 cites W1969525589 @default.
• W3124084304 cites W1978018057 @default.
• W3124084304 cites W1982478600 @default.
• W3124084304 cites W2000072919 @default.
• W3124084304 cites W2005494948 @default.
• W3124084304 cites W2029409133 @default.
• W3124084304 cites W2035583871 @default.
• W3124084304 cites W2041545409 @default.
• W3124084304 cites W2047041970 @default.
• W3124084304 cites W2048265454 @default.
• W3124084304 cites W2081236418 @default.
• W3124084304 cites W2094211844 @default.
• W3124084304 cites W2114850871 @default.
• W3124084304 cites W2115840402 @default.
• W3124084304 cites W2123543995 @default.
• W3124084304 cites W2141667093 @default.
• W3124084304 cites W2161630562 @default.
• W3124084304 cites W2173572484 @default.
• W3124084304 cites W2187858172 @default.
• W3124084304 cites W2277480360 @default.
• W3124084304 cites W2292873322 @default.
• W3124084304 cites W2354729568 @default.
• W3124084304 cites W2593767219 @default.
• W3124084304 cites W2745624257 @default.
• W3124084304 cites W2778954652 @default.
• W3124084304 cites W2982047278 @default.
• W3124084304 cites W4229681654 @default.
• W3124084304 doi "https://doi.org/10.1080/19466315.2021.1873843" @default.
• W3124084304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37197312" @default.
• W3124084304 hasPublicationYear "2021" @default.
• W3124084304 type Work @default.
• W3124084304 sameAs 3124084304 @default.
• W3124084304 citedByCount "0" @default.
• W3124084304 crossrefType "journal-article" @default.
• W3124084304 hasAuthorship W3124084304A5007801126 @default.
• W3124084304 hasAuthorship W3124084304A5008032475 @default.
• W3124084304 hasAuthorship W3124084304A5021087933 @default.
• W3124084304 hasAuthorship W3124084304A5027127519 @default.
• W3124084304 hasAuthorship W3124084304A5032073558 @default.
• W3124084304 hasAuthorship W3124084304A5037049857 @default.
• W3124084304 hasAuthorship W3124084304A5057857378 @default.
• W3124084304 hasAuthorship W3124084304A5080102032 @default.
• W3124084304 hasConcept C107673813 @default.
• W3124084304 hasConcept C112930515 @default.
• W3124084304 hasConcept C119857082 @default.
• W3124084304 hasConcept C154945302 @default.
• W3124084304 hasConcept C185592680 @default.
• W3124084304 hasConcept C2781197716 @default.
• W3124084304 hasConcept C2908647359 @default.
• W3124084304 hasConcept C41008148 @default.
• W3124084304 hasConcept C55493867 @default.
• W3124084304 hasConcept C71924100 @default.
• W3124084304 hasConcept C81917197 @default.
• W3124084304 hasConcept C99454951 @default.
• W3124084304 hasConceptScore W3124084304C107673813 @default.
• W3124084304 hasConceptScore W3124084304C112930515 @default.
• W3124084304 hasConceptScore W3124084304C119857082 @default.
• W3124084304 hasConceptScore W3124084304C154945302 @default.
• W3124084304 hasConceptScore W3124084304C185592680 @default.
• W3124084304 hasConceptScore W3124084304C2781197716 @default.
• W3124084304 hasConceptScore W3124084304C2908647359 @default.
• W3124084304 hasConceptScore W3124084304C41008148 @default.
• W3124084304 hasConceptScore W3124084304C55493867 @default.
• W3124084304 hasConceptScore W3124084304C71924100 @default.
• W3124084304 hasConceptScore W3124084304C81917197 @default.
• W3124084304 hasConceptScore W3124084304C99454951 @default.
• W3124084304 hasFunder F4320310145 @default.
• W3124084304 hasIssue "4" @default.
• W3124084304 hasLocation W31240843041 @default.
• W3124084304 hasLocation W31240843042 @default.
• W3124084304 hasOpenAccess W3124084304 @default.
• W3124084304 hasPrimaryLocation W31240843041 @default.
• W3124084304 hasRelatedWork W1990422213 @default.
• W3124084304 hasRelatedWork W2085949256 @default.
• W3124084304 hasRelatedWork W2125356288 @default.
• W3124084304 hasRelatedWork W2128302072 @default.
• W3124084304 hasRelatedWork W2144634088 @default.
• W3124084304 hasRelatedWork W2606073172 @default.
• W3124084304 hasRelatedWork W2889453578 @default.
• W3124084304 hasRelatedWork W2970622411 @default.
• W3124084304 hasRelatedWork W3154094704 @default.
• W3124084304 hasRelatedWork W2751504412 @default.

• next