Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124094196> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3124094196 abstract "Background Patients with rheumatic diseases have an excess in cardiovascular morbidity and mortality, suggesting the presence of common pathogenic abnormalities for both atherosclerosis and arthritis. One particularly atherogenic apolipoprotein, apo (a), an homologue of plasminogen, may be involved by competing with plasminogen for fibrin binding and by interfering with fibrinolysis. Objectives To study the expression of apo (a) in arthritic joints. Methods Human studies: synovial fluid and plasma from patients with osteoarthritis (OA, n = 8), rheumatoid arthritis (RA, n = 12) and other types of inflammatory arthritis (n = 12) and synovial tissues from OA and RA patients were collected. Apo (a) was quantitated by ELISA and in tissues also by RNase protection. Moreover, immunohistochemical analyses of apo (a) and fibrin were performed on synovial tissues. Animal studies: antigen-induced arthritis (AIA) was induced in genetically modified mice (LDL-receptor deficient (LDL-R -/-) mice expressing a human apoB-100 transgene (hApoB +/+) and a human apo (a) transgene (apo (a) ±)). Joint inflammation was assessed by technetium scintigraphy and histology. Results We detected the presence of apo (a) as a full-length glycoprotein in human arthritic joints. The amount of apo (a) in synovial fluid rose in proportion to plasma apo (a) levels and was higher in inflammatory arthritides than in osteoarthritis. In addition, apo (a) immunoreactive material, but not apo (a) transcripts, was detected in arthritic synovial tissues. This data indicated that synovial fluid apo (a) originates from the circulation and that diffusion through synovial tissue is facilitated in inflammatory types of arthritis. In synovial tissues, apo (a) colocalized with fibrin. These observations could be reproduced in a model of antigen-induced arthritis, using transgenic mice expressing human apo (a). In this particular mouse model, the presence of apo (a) did not change joint inflammation. Conclusion Even if the presence of apo (a) did not change the severity of AIA, we speculate that when levels of apo (a) are sufficiently high to inhibit fibrinolysis in the joints, apo (a) may exacerbate in humans the severity of the disease." @default.
- W3124094196 created "2021-02-01" @default.
- W3124094196 creator A5008889407 @default.
- W3124094196 creator A5018239875 @default.
- W3124094196 creator A5022374956 @default.
- W3124094196 creator A5033873495 @default.
- W3124094196 creator A5039631030 @default.
- W3124094196 creator A5050307056 @default.
- W3124094196 creator A5050474900 @default.
- W3124094196 creator A5058915638 @default.
- W3124094196 date "2001-06-01" @default.
- W3124094196 modified "2023-09-23" @default.
- W3124094196 title "THU0102 Apo(a), a potential link between atherosclerosis and arthritis" @default.
- W3124094196 doi "https://doi.org/10.1136/annrheumdis-2001.979" @default.
- W3124094196 hasPublicationYear "2001" @default.
- W3124094196 type Work @default.
- W3124094196 sameAs 3124094196 @default.
- W3124094196 citedByCount "0" @default.
- W3124094196 crossrefType "proceedings-article" @default.
- W3124094196 hasAuthorship W3124094196A5008889407 @default.
- W3124094196 hasAuthorship W3124094196A5018239875 @default.
- W3124094196 hasAuthorship W3124094196A5022374956 @default.
- W3124094196 hasAuthorship W3124094196A5033873495 @default.
- W3124094196 hasAuthorship W3124094196A5039631030 @default.
- W3124094196 hasAuthorship W3124094196A5050307056 @default.
- W3124094196 hasAuthorship W3124094196A5050474900 @default.
- W3124094196 hasAuthorship W3124094196A5058915638 @default.
- W3124094196 hasBestOaLocation W31240941961 @default.
- W3124094196 hasConcept C126322002 @default.
- W3124094196 hasConcept C142724271 @default.
- W3124094196 hasConcept C203014093 @default.
- W3124094196 hasConcept C204787440 @default.
- W3124094196 hasConcept C2776164576 @default.
- W3124094196 hasConcept C2776268809 @default.
- W3124094196 hasConcept C2776821229 @default.
- W3124094196 hasConcept C2776914184 @default.
- W3124094196 hasConcept C2777077863 @default.
- W3124094196 hasConcept C2777575956 @default.
- W3124094196 hasConcept C2777652487 @default.
- W3124094196 hasConcept C2778163477 @default.
- W3124094196 hasConcept C62746215 @default.
- W3124094196 hasConcept C71924100 @default.
- W3124094196 hasConceptScore W3124094196C126322002 @default.
- W3124094196 hasConceptScore W3124094196C142724271 @default.
- W3124094196 hasConceptScore W3124094196C203014093 @default.
- W3124094196 hasConceptScore W3124094196C204787440 @default.
- W3124094196 hasConceptScore W3124094196C2776164576 @default.
- W3124094196 hasConceptScore W3124094196C2776268809 @default.
- W3124094196 hasConceptScore W3124094196C2776821229 @default.
- W3124094196 hasConceptScore W3124094196C2776914184 @default.
- W3124094196 hasConceptScore W3124094196C2777077863 @default.
- W3124094196 hasConceptScore W3124094196C2777575956 @default.
- W3124094196 hasConceptScore W3124094196C2777652487 @default.
- W3124094196 hasConceptScore W3124094196C2778163477 @default.
- W3124094196 hasConceptScore W3124094196C62746215 @default.
- W3124094196 hasConceptScore W3124094196C71924100 @default.
- W3124094196 hasLocation W31240941961 @default.
- W3124094196 hasOpenAccess W3124094196 @default.
- W3124094196 hasPrimaryLocation W31240941961 @default.
- W3124094196 hasRelatedWork W1422031307 @default.
- W3124094196 hasRelatedWork W1920714223 @default.
- W3124094196 hasRelatedWork W1976711782 @default.
- W3124094196 hasRelatedWork W1977380157 @default.
- W3124094196 hasRelatedWork W2000497851 @default.
- W3124094196 hasRelatedWork W2003701156 @default.
- W3124094196 hasRelatedWork W2008953930 @default.
- W3124094196 hasRelatedWork W2013033735 @default.
- W3124094196 hasRelatedWork W2063613728 @default.
- W3124094196 hasRelatedWork W2069242723 @default.
- W3124094196 hasRelatedWork W2106033318 @default.
- W3124094196 hasRelatedWork W2137021111 @default.
- W3124094196 hasRelatedWork W2143494794 @default.
- W3124094196 hasRelatedWork W2150582828 @default.
- W3124094196 hasRelatedWork W2153291891 @default.
- W3124094196 hasRelatedWork W2372426657 @default.
- W3124094196 hasRelatedWork W2395399990 @default.
- W3124094196 hasRelatedWork W2399359733 @default.
- W3124094196 hasRelatedWork W2743692974 @default.
- W3124094196 hasRelatedWork W322382848 @default.
- W3124094196 isParatext "false" @default.
- W3124094196 isRetracted "false" @default.
- W3124094196 magId "3124094196" @default.
- W3124094196 workType "article" @default.