Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124102167> ?p ?o ?g. }
- W3124102167 endingPage "322" @default.
- W3124102167 startingPage "322" @default.
- W3124102167 abstract "In the last decade, several studies based on whole transcriptomic and genomic analyses of pancreatic tumors and their stroma have come to light to supplement histopathological stratification of pancreatic cancers with a molecular point-of-view. Three main molecular studies: Collisson et al. 2011, Moffitt et al. 2015 and Bailey et al. 2016 have found specific gene signatures, which identify different molecular subtypes of pancreatic cancer and provide a comprehensive stratification for both a personalized treatment or to identify potential druggable targets. However, the routine clinical management of pancreatic cancer does not consider a broad molecular analysis of each patient, due probably to the lack of target therapies for this tumor. Therefore, the current treatment decision is taken based on patients´ clinicopathological features and performance status. Histopathological evaluation of tumor samples could reveal many other attributes not only from tumor cells but also from their microenvironment specially about the presence of pancreatic stellate cells, regulatory T cells, tumor-associated macrophages, myeloid derived suppressor cells and extracellular matrix structure. In the present article, we revise the four molecular subtypes proposed by Bailey et al. and associate each subtype with other reported molecular subtypes. Moreover, we provide for each subtype a potential description of the tumor microenvironment that may influence treatment response according to the gene expression profile, the mutational landscape and their associated histology." @default.
- W3124102167 created "2021-02-01" @default.
- W3124102167 creator A5028200237 @default.
- W3124102167 creator A5034758754 @default.
- W3124102167 creator A5075463200 @default.
- W3124102167 date "2021-01-17" @default.
- W3124102167 modified "2023-10-15" @default.
- W3124102167 title "The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance" @default.
- W3124102167 cites W113716995 @default.
- W3124102167 cites W1497915798 @default.
- W3124102167 cites W1504049064 @default.
- W3124102167 cites W1514206265 @default.
- W3124102167 cites W1545264161 @default.
- W3124102167 cites W1641611552 @default.
- W3124102167 cites W1836362594 @default.
- W3124102167 cites W1844836761 @default.
- W3124102167 cites W1968812902 @default.
- W3124102167 cites W1974225259 @default.
- W3124102167 cites W1977103256 @default.
- W3124102167 cites W1979342940 @default.
- W3124102167 cites W1982821807 @default.
- W3124102167 cites W1983959103 @default.
- W3124102167 cites W1984633743 @default.
- W3124102167 cites W1990288931 @default.
- W3124102167 cites W2001573760 @default.
- W3124102167 cites W2003943777 @default.
- W3124102167 cites W2004150448 @default.
- W3124102167 cites W2012276721 @default.
- W3124102167 cites W2012701020 @default.
- W3124102167 cites W2014434319 @default.
- W3124102167 cites W2016699821 @default.
- W3124102167 cites W2021709978 @default.
- W3124102167 cites W2026587982 @default.
- W3124102167 cites W2028433016 @default.
- W3124102167 cites W2029054121 @default.
- W3124102167 cites W2029669820 @default.
- W3124102167 cites W2050164769 @default.
- W3124102167 cites W2053873040 @default.
- W3124102167 cites W2055703363 @default.
- W3124102167 cites W2066230562 @default.
- W3124102167 cites W2068984568 @default.
- W3124102167 cites W2071190021 @default.
- W3124102167 cites W2075253603 @default.
- W3124102167 cites W2076921551 @default.
- W3124102167 cites W2086834665 @default.
- W3124102167 cites W2091140432 @default.
- W3124102167 cites W2092339045 @default.
- W3124102167 cites W2094173258 @default.
- W3124102167 cites W2094358946 @default.
- W3124102167 cites W2099069796 @default.
- W3124102167 cites W2102803053 @default.
- W3124102167 cites W2102882750 @default.
- W3124102167 cites W2108360660 @default.
- W3124102167 cites W2109978756 @default.
- W3124102167 cites W2113533161 @default.
- W3124102167 cites W2120742807 @default.
- W3124102167 cites W2122403898 @default.
- W3124102167 cites W2123996418 @default.
- W3124102167 cites W2126932404 @default.
- W3124102167 cites W2129197203 @default.
- W3124102167 cites W2130409622 @default.
- W3124102167 cites W2133298966 @default.
- W3124102167 cites W2135802413 @default.
- W3124102167 cites W2138482180 @default.
- W3124102167 cites W2139103645 @default.
- W3124102167 cites W2140525205 @default.
- W3124102167 cites W2151021631 @default.
- W3124102167 cites W2154790710 @default.
- W3124102167 cites W2157590016 @default.
- W3124102167 cites W2161558994 @default.
- W3124102167 cites W2169837598 @default.
- W3124102167 cites W2169859344 @default.
- W3124102167 cites W2169895148 @default.
- W3124102167 cites W2193423443 @default.
- W3124102167 cites W2232697670 @default.
- W3124102167 cites W2242701546 @default.
- W3124102167 cites W2253230571 @default.
- W3124102167 cites W2256682118 @default.
- W3124102167 cites W2270388924 @default.
- W3124102167 cites W2277966485 @default.
- W3124102167 cites W2285093314 @default.
- W3124102167 cites W2301831168 @default.
- W3124102167 cites W2321400052 @default.
- W3124102167 cites W2433880588 @default.
- W3124102167 cites W2470222015 @default.
- W3124102167 cites W2508758420 @default.
- W3124102167 cites W2519377527 @default.
- W3124102167 cites W2530909341 @default.
- W3124102167 cites W2559093989 @default.
- W3124102167 cites W2560101007 @default.
- W3124102167 cites W2566650374 @default.
- W3124102167 cites W2590390825 @default.
- W3124102167 cites W2590750824 @default.
- W3124102167 cites W2604454943 @default.
- W3124102167 cites W2736312236 @default.
- W3124102167 cites W2736340856 @default.
- W3124102167 cites W2748710555 @default.
- W3124102167 cites W2749041432 @default.