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- W3124117961 abstract "Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates. The catalytic and enantioselective synthesis of alkyl amines from readily accessible precursors is challenging. Here we develop a nickel-catalyzed hydroalkylation method to assemble a wide range of chiral alkyl amines from enecarbamates (N-Cbz-protected enamines) and alkyl halides with high regio- and enantioselectivity. The method works for both nonactivated and activated alkyl halides and is able to produce enantiomerically enriched amines with two minimally differentiated α-alkyl substituents. The mild conditions lead to high functional group tolerance, which is demonstrated in the postproduct functionalization of many natural products and drug molecules, as well as the synthesis of chiral building blocks and key intermediates to bioactive compounds." @default.
- W3124117961 created "2021-02-01" @default.
- W3124117961 creator A5030612940 @default.
- W3124117961 creator A5076829051 @default.
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- W3124117961 date "2021-01-22" @default.
- W3124117961 modified "2023-10-04" @default.
- W3124117961 title "Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates" @default.
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- W3124117961 doi "https://doi.org/10.1021/jacs.0c11630" @default.
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