FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W31241181> ?p ?o ?g. }

• W31241181 endingPage "4" @default.
• W31241181 startingPage "S61" @default.
• W31241181 abstract "We investigated the cytotoxicity and the interaction with low-dose radiation (1-4Gy) of tirapazamine by the in vitro cytokinesis-block micronucleus (MN) assay. Murine SCCVII and human melanoma (G-361) cells were treated with tirapazamine under aerobic or hypoxic conditions for 1 h and the MN frequency was determined using cytochalasin-B. The cells were also treated with or without tirapazamine or KU-2285 (hypoxic cell sensitiser) under hypoxic conditions and irradiated with or without reaeration of the cell suspensions. A dose-dependent increase of MN frequency was observed by tirapazamine treatment and the hypoxic toxicity ratio was about 130 for SCCVII and 37 for G-361. The radiation dose-response curves of MN frequency suggested that the interaction of tirapazamine with irradiation appeared to be essentially additive in both cell lines. In contrast, the dose-response curve became steeper by KU-2285 treatment. Combined effects of tirapazamine and irradiation on the hypoxic cells were much higher than the radiation effect on aerobic cells at low doses, while the effects of KU-2285 did not exceed that of aerobic irradiation. In conclusion, tirapazamine appeared to be superior to hypoxic radiosensitisers at clinically relevant doses, not because of aerobic radiosensitisation but because of its potent hypoxic cytotoxicity additive to radiation effect." @default.
• W31241181 created "2016-06-24" @default.
• W31241181 creator A5013307791 @default.
• W31241181 creator A5015259799 @default.
• W31241181 creator A5040691530 @default.
• W31241181 creator A5050452238 @default.
• W31241181 creator A5054458732 @default.
• W31241181 creator A5066274607 @default.
• W31241181 creator A5067546830 @default.
• W31241181 creator A5071240286 @default.
• W31241181 creator A5078435301 @default.
• W31241181 date "1996-07-01" @default.
• W31241181 modified "2023-09-23" @default.
• W31241181 title "Tirapazamine: hypoxic cytotoxicity and interaction with radiation as assessed by the micronucleus assay." @default.
• W31241181 cites W1966336358 @default.
• W31241181 cites W1975462388 @default.
• W31241181 cites W1982374730 @default.
• W31241181 cites W1994555849 @default.
• W31241181 cites W1996501114 @default.
• W31241181 cites W2005146092 @default.
• W31241181 cites W2013267151 @default.
• W31241181 cites W2017742180 @default.
• W31241181 cites W2057088400 @default.
• W31241181 cites W2066082960 @default.
• W31241181 cites W2077266389 @default.
• W31241181 cites W2081370503 @default.
• W31241181 cites W2085651157 @default.
• W31241181 cites W2085851177 @default.
• W31241181 cites W2090839918 @default.
• W31241181 cites W2113336365 @default.
• W31241181 cites W2117181100 @default.
• W31241181 cites W2145953677 @default.
• W31241181 cites W2155258039 @default.
• W31241181 cites W2168552512 @default.
• W31241181 cites W2330695030 @default.
• W31241181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2149998" @default.
• W31241181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8763848" @default.
• W31241181 hasPublicationYear "1996" @default.
• W31241181 type Work @default.
• W31241181 sameAs 31241181 @default.
• W31241181 citedByCount "4" @default.
• W31241181 countsByYear W312411812017 @default.
• W31241181 crossrefType "journal-article" @default.
• W31241181 hasAuthorship W31241181A5013307791 @default.
• W31241181 hasAuthorship W31241181A5015259799 @default.
• W31241181 hasAuthorship W31241181A5040691530 @default.
• W31241181 hasAuthorship W31241181A5050452238 @default.
• W31241181 hasAuthorship W31241181A5054458732 @default.
• W31241181 hasAuthorship W31241181A5066274607 @default.
• W31241181 hasAuthorship W31241181A5067546830 @default.
• W31241181 hasAuthorship W31241181A5071240286 @default.
• W31241181 hasAuthorship W31241181A5078435301 @default.
• W31241181 hasConcept C109316439 @default.
• W31241181 hasConcept C111337013 @default.
• W31241181 hasConcept C121332964 @default.
• W31241181 hasConcept C12554922 @default.
• W31241181 hasConcept C178790620 @default.
• W31241181 hasConcept C185544564 @default.
• W31241181 hasConcept C185592680 @default.
• W31241181 hasConcept C202751555 @default.
• W31241181 hasConcept C206684579 @default.
• W31241181 hasConcept C2776313096 @default.
• W31241181 hasConcept C29730261 @default.
• W31241181 hasConcept C36681516 @default.
• W31241181 hasConcept C45080847 @default.
• W31241181 hasConcept C55493867 @default.
• W31241181 hasConcept C86803240 @default.
• W31241181 hasConceptScore W31241181C109316439 @default.
• W31241181 hasConceptScore W31241181C111337013 @default.
• W31241181 hasConceptScore W31241181C121332964 @default.
• W31241181 hasConceptScore W31241181C12554922 @default.
• W31241181 hasConceptScore W31241181C178790620 @default.
• W31241181 hasConceptScore W31241181C185544564 @default.
• W31241181 hasConceptScore W31241181C185592680 @default.
• W31241181 hasConceptScore W31241181C202751555 @default.
• W31241181 hasConceptScore W31241181C206684579 @default.
• W31241181 hasConceptScore W31241181C2776313096 @default.
• W31241181 hasConceptScore W31241181C29730261 @default.
• W31241181 hasConceptScore W31241181C36681516 @default.
• W31241181 hasConceptScore W31241181C45080847 @default.
• W31241181 hasConceptScore W31241181C55493867 @default.
• W31241181 hasConceptScore W31241181C86803240 @default.
• W31241181 hasLocation W312411811 @default.
• W31241181 hasOpenAccess W31241181 @default.
• W31241181 hasPrimaryLocation W312411811 @default.
• W31241181 hasRelatedWork W2049571292 @default.
• W31241181 hasRelatedWork W2063828233 @default.
• W31241181 hasRelatedWork W2085165828 @default.
• W31241181 hasRelatedWork W2141088228 @default.
• W31241181 hasRelatedWork W2330042615 @default.
• W31241181 hasRelatedWork W2352979913 @default.
• W31241181 hasRelatedWork W2368230152 @default.
• W31241181 hasRelatedWork W2418878777 @default.
• W31241181 hasRelatedWork W2419141406 @default.
• W31241181 hasRelatedWork W31241181 @default.
• W31241181 hasVolume "27" @default.
• W31241181 isParatext "false" @default.
• W31241181 isRetracted "false" @default.

• next