FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124134382> ?p ?o ?g. }

• W3124134382 abstract "Abstract Hyaluronic acid (HA) is a high value glycosaminoglycan mostly used in health and cosmetic applications. Commercial HA is produced from animal tissues or in toxigenic bacteria of the genus Streptococcus grown in complex media, which are expensive and raise environmental concerns due to the disposal of large amounts of broth with high organic loads. Other microorganisms were proposed as hosts for the heterologous production of HA, but the methods are still costly. The extraordinary capacity of this biopolymer to bind and retain water attracts interest for large scale applications where biodegradable materials are needed, but its high cost and safety concerns are barriers for its adoption. Bacillus subtilis 3NA strain is prototrophic, amenable for genetic manipulation, GRAS, and can rapidly reach high cell densities in salt-based media. These phenotypic traits were exploited to create a platform for biomolecule production using HA as a proof of concept. First, the 3NA strain was engineered to produce HA; second, a chemically defined medium was formulated using commodity-priced inorganic salts combined at the stoichiometric ratios needed to build the necessary quantities of biomass and HA; and third, a scalable fermentation process, where HA can be produced at the maximum volumetric productivity (VP), was designed. A comparative economic analysis against other methods indicates that the new process may increase the operating profit of a manufacturing plant by more than 100 %. The host, the culture medium, and the rationale employed to develop the fermentation process described here, introduce an IP free platform that could be adaptable for production of other biomolecules. Key Points A platform for the production of biomolecules was designed based on B. subtilis 3NA, a chemically defined medium and a fermentation process. As proof of concept, high quality hyaluronic acid was produced with an environmentally friendly process. A techno-economic analysis indicates that the process is more that 100% profitable than current methods." @default.
• W3124134382 created "2021-02-01" @default.
• W3124134382 creator A5020401119 @default.
• W3124134382 creator A5026105193 @default.
• W3124134382 creator A5029051410 @default.
• W3124134382 creator A5059844561 @default.
• W3124134382 creator A5067332102 @default.
• W3124134382 creator A5072753372 @default.
• W3124134382 creator A5084181476 @default.
• W3124134382 date "2021-01-19" @default.
• W3124134382 modified "2023-10-18" @default.
• W3124134382 title "Low cost and sustainable hyaluronic acid production in a manufacturing platform based on Bacillus subtilis 3NA strain" @default.
• W3124134382 cites W1678194650 @default.
• W3124134382 cites W1678318463 @default.
• W3124134382 cites W1964925190 @default.
• W3124134382 cites W1971262916 @default.
• W3124134382 cites W1993126632 @default.
• W3124134382 cites W2003500399 @default.
• W3124134382 cites W2021743090 @default.
• W3124134382 cites W2023864321 @default.
• W3124134382 cites W2033134248 @default.
• W3124134382 cites W2045813821 @default.
• W3124134382 cites W2048318784 @default.
• W3124134382 cites W2067171708 @default.
• W3124134382 cites W2070528883 @default.
• W3124134382 cites W2072029917 @default.
• W3124134382 cites W2076018628 @default.
• W3124134382 cites W2076389019 @default.
• W3124134382 cites W2077542510 @default.
• W3124134382 cites W2082889803 @default.
• W3124134382 cites W2093763547 @default.
• W3124134382 cites W2100491597 @default.
• W3124134382 cites W2127176722 @default.
• W3124134382 cites W2150804231 @default.
• W3124134382 cites W2165118472 @default.
• W3124134382 cites W2291204809 @default.
• W3124134382 cites W2331795678 @default.
• W3124134382 cites W2464906938 @default.
• W3124134382 cites W2516332350 @default.
• W3124134382 cites W2521216131 @default.
• W3124134382 cites W2582162368 @default.
• W3124134382 cites W2737218700 @default.
• W3124134382 cites W2767325925 @default.
• W3124134382 cites W2795291622 @default.
• W3124134382 cites W2801885456 @default.
• W3124134382 cites W2809231499 @default.
• W3124134382 cites W2949361292 @default.
• W3124134382 cites W2950882446 @default.
• W3124134382 cites W2952467237 @default.
• W3124134382 cites W3085982539 @default.
• W3124134382 cites W4239241386 @default.
• W3124134382 cites W579402371 @default.
• W3124134382 doi "https://doi.org/10.1101/2021.01.18.427161" @default.
• W3124134382 hasPublicationYear "2021" @default.
• W3124134382 type Work @default.
• W3124134382 sameAs 3124134382 @default.
• W3124134382 citedByCount "1" @default.
• W3124134382 countsByYear W31241343822022 @default.
• W3124134382 crossrefType "posted-content" @default.
• W3124134382 hasAuthorship W3124134382A5020401119 @default.
• W3124134382 hasAuthorship W3124134382A5026105193 @default.
• W3124134382 hasAuthorship W3124134382A5029051410 @default.
• W3124134382 hasAuthorship W3124134382A5059844561 @default.
• W3124134382 hasAuthorship W3124134382A5067332102 @default.
• W3124134382 hasAuthorship W3124134382A5072753372 @default.
• W3124134382 hasAuthorship W3124134382A5084181476 @default.
• W3124134382 hasBestOaLocation W31241343821 @default.
• W3124134382 hasConcept C100544194 @default.
• W3124134382 hasConcept C115540264 @default.
• W3124134382 hasConcept C127413603 @default.
• W3124134382 hasConcept C150903083 @default.
• W3124134382 hasConcept C178790620 @default.
• W3124134382 hasConcept C183696295 @default.
• W3124134382 hasConcept C185592680 @default.
• W3124134382 hasConcept C2777272437 @default.
• W3124134382 hasConcept C2778636629 @default.
• W3124134382 hasConcept C31903555 @default.
• W3124134382 hasConcept C3952536 @default.
• W3124134382 hasConcept C521977710 @default.
• W3124134382 hasConcept C523546767 @default.
• W3124134382 hasConcept C528095902 @default.
• W3124134382 hasConcept C54355233 @default.
• W3124134382 hasConcept C55493867 @default.
• W3124134382 hasConcept C6557445 @default.
• W3124134382 hasConcept C67568554 @default.
• W3124134382 hasConcept C86803240 @default.
• W3124134382 hasConceptScore W3124134382C100544194 @default.
• W3124134382 hasConceptScore W3124134382C115540264 @default.
• W3124134382 hasConceptScore W3124134382C127413603 @default.
• W3124134382 hasConceptScore W3124134382C150903083 @default.
• W3124134382 hasConceptScore W3124134382C178790620 @default.
• W3124134382 hasConceptScore W3124134382C183696295 @default.
• W3124134382 hasConceptScore W3124134382C185592680 @default.
• W3124134382 hasConceptScore W3124134382C2777272437 @default.
• W3124134382 hasConceptScore W3124134382C2778636629 @default.
• W3124134382 hasConceptScore W3124134382C31903555 @default.
• W3124134382 hasConceptScore W3124134382C3952536 @default.
• W3124134382 hasConceptScore W3124134382C521977710 @default.
• W3124134382 hasConceptScore W3124134382C523546767 @default.
• W3124134382 hasConceptScore W3124134382C528095902 @default.

• next