Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124136762> ?p ?o ?g. }
- W3124136762 endingPage "111890" @default.
- W3124136762 startingPage "111890" @default.
- W3124136762 abstract "To overcome the natural barriers of the ocular system that limit the topical delivery of therapeutically active molecules to the posterior eye, nanoscale drug carriers can be used to improve transcorneal drug transport. So far, using mucoadhesive drug carriers has been put forward as the most promising strategy to optimize drug transport. However, if the mucoadhesivity of a drug carrier is too high, this might limit the diffusive entry of molecules/drug carriers into the vitreous. In this study, we show how modulating the net charge of biopolymer-based drug carrier particles alters not only their mucoadhesivity but also other important properties, e.g., their stability, drug loading capacity and drug release profiles. Compared to simple aqueous solutions of free drug molecules as used in current treatments, nanoparticulate drug carriers with intermediate mucoadhesivity show improved drug transport across the corneal barrier. Therefore, our study shows that mucoadhesion of drug carrier particles is a feature that needs to be considered with great care – not only for ocular delivery attempts but for all drug delivery approaches dealing with mucosal barriers." @default.
- W3124136762 created "2021-02-01" @default.
- W3124136762 creator A5006203687 @default.
- W3124136762 creator A5010965725 @default.
- W3124136762 creator A5016223662 @default.
- W3124136762 creator A5019477749 @default.
- W3124136762 date "2021-02-01" @default.
- W3124136762 modified "2023-10-01" @default.
- W3124136762 title "Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across the corneal barrier" @default.
- W3124136762 cites W138082187 @default.
- W3124136762 cites W1533489260 @default.
- W3124136762 cites W1607700524 @default.
- W3124136762 cites W1964012010 @default.
- W3124136762 cites W1964186648 @default.
- W3124136762 cites W1966607000 @default.
- W3124136762 cites W1969460620 @default.
- W3124136762 cites W1969666381 @default.
- W3124136762 cites W1973587651 @default.
- W3124136762 cites W1980982017 @default.
- W3124136762 cites W1982384502 @default.
- W3124136762 cites W1986180285 @default.
- W3124136762 cites W1997547505 @default.
- W3124136762 cites W2002128115 @default.
- W3124136762 cites W2002826940 @default.
- W3124136762 cites W2005395441 @default.
- W3124136762 cites W2007950027 @default.
- W3124136762 cites W2015097479 @default.
- W3124136762 cites W2026156584 @default.
- W3124136762 cites W2031964173 @default.
- W3124136762 cites W2042740379 @default.
- W3124136762 cites W2057266151 @default.
- W3124136762 cites W2060834487 @default.
- W3124136762 cites W2068119665 @default.
- W3124136762 cites W2090243647 @default.
- W3124136762 cites W2112515081 @default.
- W3124136762 cites W2114739490 @default.
- W3124136762 cites W2138170976 @default.
- W3124136762 cites W2144461025 @default.
- W3124136762 cites W2296417426 @default.
- W3124136762 cites W2313530357 @default.
- W3124136762 cites W2750815580 @default.
- W3124136762 cites W2765257485 @default.
- W3124136762 cites W2771396902 @default.
- W3124136762 cites W2885781018 @default.
- W3124136762 cites W2896408442 @default.
- W3124136762 cites W2897190770 @default.
- W3124136762 cites W2898144829 @default.
- W3124136762 cites W2909577384 @default.
- W3124136762 cites W2947249697 @default.
- W3124136762 cites W3004456848 @default.
- W3124136762 cites W3123472196 @default.
- W3124136762 cites W4376595529 @default.
- W3124136762 doi "https://doi.org/10.1016/j.msec.2021.111890" @default.
- W3124136762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33579502" @default.
- W3124136762 hasPublicationYear "2021" @default.
- W3124136762 type Work @default.
- W3124136762 sameAs 3124136762 @default.
- W3124136762 citedByCount "8" @default.
- W3124136762 countsByYear W31241367622021 @default.
- W3124136762 countsByYear W31241367622022 @default.
- W3124136762 countsByYear W31241367622023 @default.
- W3124136762 crossrefType "journal-article" @default.
- W3124136762 hasAuthorship W3124136762A5006203687 @default.
- W3124136762 hasAuthorship W3124136762A5010965725 @default.
- W3124136762 hasAuthorship W3124136762A5016223662 @default.
- W3124136762 hasAuthorship W3124136762A5019477749 @default.
- W3124136762 hasConcept C126511603 @default.
- W3124136762 hasConcept C13245373 @default.
- W3124136762 hasConcept C155672457 @default.
- W3124136762 hasConcept C171250308 @default.
- W3124136762 hasConcept C178790620 @default.
- W3124136762 hasConcept C185592680 @default.
- W3124136762 hasConcept C192562407 @default.
- W3124136762 hasConcept C2778636629 @default.
- W3124136762 hasConcept C2779820397 @default.
- W3124136762 hasConcept C2780020223 @default.
- W3124136762 hasConcept C2780035454 @default.
- W3124136762 hasConcept C521977710 @default.
- W3124136762 hasConcept C71924100 @default.
- W3124136762 hasConcept C98274493 @default.
- W3124136762 hasConceptScore W3124136762C126511603 @default.
- W3124136762 hasConceptScore W3124136762C13245373 @default.
- W3124136762 hasConceptScore W3124136762C155672457 @default.
- W3124136762 hasConceptScore W3124136762C171250308 @default.
- W3124136762 hasConceptScore W3124136762C178790620 @default.
- W3124136762 hasConceptScore W3124136762C185592680 @default.
- W3124136762 hasConceptScore W3124136762C192562407 @default.
- W3124136762 hasConceptScore W3124136762C2778636629 @default.
- W3124136762 hasConceptScore W3124136762C2779820397 @default.
- W3124136762 hasConceptScore W3124136762C2780020223 @default.
- W3124136762 hasConceptScore W3124136762C2780035454 @default.
- W3124136762 hasConceptScore W3124136762C521977710 @default.
- W3124136762 hasConceptScore W3124136762C71924100 @default.
- W3124136762 hasConceptScore W3124136762C98274493 @default.
- W3124136762 hasFunder F4320320879 @default.
- W3124136762 hasLocation W31241367621 @default.
- W3124136762 hasOpenAccess W3124136762 @default.
- W3124136762 hasPrimaryLocation W31241367621 @default.