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• W3124147873 endingPage "102560" @default.
• W3124147873 startingPage "102560" @default.
• W3124147873 abstract "LINEs are retrotransposable elements found in diverse organisms. Their activity is kept in check by several mechanisms, including transcriptional silencing. Here we have analyzed the transcription status of LINE1 copies in the early-branching parasitic protist Entamoeba histolytica. Full-length EhLINE1 encodes ORF1, and ORF2 with reverse transcriptase (RT) and endonuclease (EN) domains. RNA-Seq analysis of EhLINE1 copies (both truncated and full-length) showed unique features. Firstly, although 20/41 transcribed copies were full-length, we failed to detect any full-length transcripts. Rather, sense-strand transcripts mapped to the functional domains- ORF1, RT and EN. Secondly, there was strong antisense transcription specifically from RT domain. No antisense transcripts were seen from ORF1. Antisense RT transcripts did not encode known functional peptides. They could possibly be involved in attenuating translation of RT domain, as we failed to detect ORF2p, whereas ORF1p was detectable. Lack of full-length transcripts and strong antisense RT expression may serve to limit EhLINE1 retrotransposition." @default.
• W3124147873 created "2021-02-01" @default.
• W3124147873 creator A5031877851 @default.
• W3124147873 creator A5038390829 @default.
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• W3124147873 creator A5072103359 @default.
• W3124147873 creator A5075695450 @default.
• W3124147873 date "2021-03-01" @default.
• W3124147873 modified "2023-10-14" @default.
• W3124147873 title "Transcriptomic analysis of Entamoeba histolytica reveals domain-specific sense strand expression of LINE-encoded ORFs with massive antisense expression of RT domain" @default.
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• W3124147873 doi "https://doi.org/10.1016/j.plasmid.2021.102560" @default.
• W3124147873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33482228" @default.
• W3124147873 hasPublicationYear "2021" @default.
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