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• W3124165904 abstract "Abstract Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. Half maximal inhibitory concentrations (IC 50 ) of small molecules SM2 and SM6 were, respectively, 9- and 18-fold higher for human than murine PSCs, while the IC 50 of SM8 was comparable for both PSC groups. Treatment of murine embryoid bodies in suspension differentiation cultures with the most effective small molecule SM6 significantly reduced PSC and non-PSC contamination and enriched CM populations that would otherwise be eliminated in genetic selection approaches. All tested salicylic diamines exerted their toxicity by inhibiting the oxygen consumption rate (OCR) in PSCs. No or only minimal and reversible effects on OCR, sarcomeric integrity, DNA stability, apoptosis rate, ROS levels or beating frequency were observed in PSC-CMs, although effects on human PSC-CMs seemed to be more deleterious at higher SM-concentrations. Teratoma formation from SM6-treated murine PSC-CMs was abolished or delayed compared to untreated cells. We conclude that salicylic diamines represent promising compounds for PSC removal and enrichment of CMs without the need for other selection strategies." @default.
• W3124165904 created "2021-02-01" @default.
• W3124165904 creator A5000656991 @default.
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• W3124165904 date "2021-01-27" @default.
• W3124165904 modified "2023-09-27" @default.
• W3124165904 title "Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations" @default.
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• W3124165904 doi "https://doi.org/10.1038/s41598-021-81351-z" @default.
• W3124165904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7841182" @default.
• W3124165904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33504837" @default.
• W3124165904 hasPublicationYear "2021" @default.
• W3124165904 type Work @default.
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• W3124165904 hasAuthorship W3124165904A5000656991 @default.
• W3124165904 hasAuthorship W3124165904A5006334851 @default.
• W3124165904 hasAuthorship W3124165904A5010161793 @default.
• W3124165904 hasAuthorship W3124165904A5010624046 @default.

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