FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124173816> ?p ?o ?g. }

• W3124173816 endingPage "625" @default.
• W3124173816 startingPage "606" @default.
• W3124173816 abstract "The BAP1 gene has emerged as a major tumor suppressor mutated with various frequencies in numerous human malignancies, including uveal melanoma, malignant pleural mesothelioma, clear cell renal cell carcinoma, intrahepatic cholangiocarcinoma, hepatocellular carcinoma, and thymic epithelial tumors. BAP1 mutations are also observed at low frequency in other malignancies including breast, colorectal, pancreatic, and bladder cancers. BAP1 germline mutations are associated with high incidence of mesothelioma, uveal melanoma, and other cancers, defining the BAP1 cancer syndrome. Interestingly, germline BAP1 mutations constitute an important paradigm for gene-environment interactions, as loss of BAP1 predisposes to carcinogen-induced tumorigenesis. Inactivating mutations of BAP1 are also identified in sporadic cancers, denoting the importance of this gene for normal tissue homeostasis and tumor suppression, although some oncogenic properties have also been attributed to BAP1. BAP1 belongs to the deubiquitinase superfamily of enzymes, which are responsible for the maturation and turnover of ubiquitin as well as the reversal of substrate ubiquitination, thus regulating ubiquitin signaling. BAP1 is predominantly nuclear and interacts with several chromatin-associated factors, assembling multi-protein complexes with mutually exclusive partners. BAP1 exerts its function through highly regulated deubiquitination of its substrates. As such, BAP1 orchestrates chromatin-associated processes including gene expression, DNA replication, and DNA repair. BAP1 also exerts cytoplasmic functions, notably in regulating Ca2+ signaling at the endoplasmic reticulum. This DUB is also subjected to multiple post-translational modifications, notably phosphorylation and ubiquitination, indicating that several signaling pathways tightly regulate its function. Recent progress indicated that BAP1 plays essential roles in multiple cellular processes including cell proliferation and differentiation, cell metabolism, as well as cell survival and death. In this review, we summarize the biological and molecular functions of BAP1 and explain how the inactivation of this DUB might cause human cancers. We also highlight some of the unresolved questions and suggest potential new directions." @default.
• W3124173816 created "2021-02-01" @default.
• W3124173816 creator A5006442726 @default.
• W3124173816 creator A5017533525 @default.
• W3124173816 creator A5038736461 @default.
• W3124173816 creator A5052493476 @default.
• W3124173816 creator A5065805086 @default.
• W3124173816 creator A5065879015 @default.
• W3124173816 creator A5067701806 @default.
• W3124173816 date "2021-01-18" @default.
• W3124173816 modified "2023-10-09" @default.
• W3124173816 title "Roles and mechanisms of BAP1 deubiquitinase in tumor suppression" @default.
• W3124173816 cites W1496251975 @default.
• W3124173816 cites W1498250169 @default.
• W3124173816 cites W1517688143 @default.
• W3124173816 cites W1963954727 @default.
• W3124173816 cites W1968657935 @default.
• W3124173816 cites W1973904343 @default.
• W3124173816 cites W1974987314 @default.
• W3124173816 cites W1979920225 @default.
• W3124173816 cites W1979946545 @default.
• W3124173816 cites W1980689264 @default.
• W3124173816 cites W1981327848 @default.
• W3124173816 cites W1986302429 @default.
• W3124173816 cites W1987211450 @default.
• W3124173816 cites W1989561383 @default.
• W3124173816 cites W1992048873 @default.
• W3124173816 cites W1994067160 @default.
• W3124173816 cites W1997183854 @default.
• W3124173816 cites W1999736822 @default.
• W3124173816 cites W1999813105 @default.
• W3124173816 cites W2003053220 @default.
• W3124173816 cites W2003653198 @default.
• W3124173816 cites W2004029643 @default.
• W3124173816 cites W2005071089 @default.
• W3124173816 cites W2006752813 @default.
• W3124173816 cites W2007265317 @default.
• W3124173816 cites W2007541023 @default.
• W3124173816 cites W2007555374 @default.
• W3124173816 cites W2008954479 @default.
• W3124173816 cites W2016311718 @default.
• W3124173816 cites W2024413697 @default.
• W3124173816 cites W2025391163 @default.
• W3124173816 cites W2028003321 @default.
• W3124173816 cites W2030823261 @default.
• W3124173816 cites W2033522521 @default.
• W3124173816 cites W2037824079 @default.
• W3124173816 cites W2040595224 @default.
• W3124173816 cites W2040742197 @default.
• W3124173816 cites W2042418635 @default.
• W3124173816 cites W2042499074 @default.
• W3124173816 cites W2047777235 @default.
• W3124173816 cites W2049183064 @default.
• W3124173816 cites W2050426104 @default.
• W3124173816 cites W2054550040 @default.
• W3124173816 cites W2057802075 @default.
• W3124173816 cites W2060870400 @default.
• W3124173816 cites W2067441802 @default.
• W3124173816 cites W2068470826 @default.
• W3124173816 cites W2071818162 @default.
• W3124173816 cites W2072087420 @default.
• W3124173816 cites W2072155586 @default.
• W3124173816 cites W2072355125 @default.
• W3124173816 cites W2072630073 @default.
• W3124173816 cites W2073904860 @default.
• W3124173816 cites W2077436902 @default.
• W3124173816 cites W2077457197 @default.
• W3124173816 cites W2085531754 @default.
• W3124173816 cites W2092892924 @default.
• W3124173816 cites W2093090845 @default.
• W3124173816 cites W2096469206 @default.
• W3124173816 cites W2106969933 @default.
• W3124173816 cites W2108196925 @default.
• W3124173816 cites W2109361919 @default.
• W3124173816 cites W2113035823 @default.
• W3124173816 cites W2114024085 @default.
• W3124173816 cites W2119036906 @default.
• W3124173816 cites W2120628024 @default.
• W3124173816 cites W2124470681 @default.
• W3124173816 cites W2125161768 @default.
• W3124173816 cites W2127015328 @default.
• W3124173816 cites W2130239280 @default.
• W3124173816 cites W2134244982 @default.
• W3124173816 cites W2135149951 @default.
• W3124173816 cites W2147450167 @default.
• W3124173816 cites W2149067994 @default.
• W3124173816 cites W2149883217 @default.
• W3124173816 cites W2150056778 @default.
• W3124173816 cites W2150322921 @default.
• W3124173816 cites W2162373413 @default.
• W3124173816 cites W2176258152 @default.
• W3124173816 cites W2194928240 @default.
• W3124173816 cites W2204974798 @default.
• W3124173816 cites W2218992355 @default.
• W3124173816 cites W2219837350 @default.
• W3124173816 cites W2258553021 @default.
• W3124173816 cites W2261455423 @default.
• W3124173816 cites W2272704264 @default.

• next