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- W3124179986 abstract "The induction and maintenance of T-cell memory is critical to the success of novel vaccines. A newlydescribed subset of memory CD8 T-cells defined by intermediate expression of the chemokine receptor CX3CR1, were shown to have self-renewal, proliferative and tissue-surveillance properties relevant to vaccine-induced memory. We tracked these cells in situations where memory is sustained at high levels – memory “inflation” induced by cytomegalovirus (CMV) and adenovirus-vectored vaccines. In mice, both CMV and vaccine-induced inflationary T-cells showed sustained high levels of CX3R1int cells exhibiting an effector-memory phenotype, characteristic of inflationary pools. In humans, CX3CR1int CD8 T-cells were strongly induced following administration of an adenovirus-vectored vaccine for HCV (ChAd3-NSmut) and during natural CMV infection, and were associated with a memory phenotype similar to that in mice. These data indicate that CX3CR1int memory cells form a substantial component of the memory pool in response to persistent viruses and vaccines in both mouse and man." @default.
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- W3124179986 date "2018-01-01" @default.
- W3124179986 modified "2023-09-26" @default.
- W3124179986 title "Induction and maintenance of CX3CR1-intermediate peripheral memory CD8 T cells by persistent viruses and novel vaccines" @default.
- W3124179986 doi "https://doi.org/10.2139/ssrn.3151996" @default.
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