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• W3124190639 endingPage "1180" @default.
• W3124190639 startingPage "1167" @default.
• W3124190639 abstract "Extremophiles adopt strategies to deal with different environmental stresses, some of which are severely damaging to their cell membrane. To combat high osmotic stress, deep-sea organisms synthesize osmolytes, small polar organic molecules, like trimethylamine-N-oxide (TMAO), and incorporate them in the cell. TMAO is known to protect cells from high osmotic or hydrostatic pressure. Several experimental and simulation studies have revealed the roles of such osmolytes on stabilizing proteins. In contrast, the effect of osmolytes on the lipid membrane is poorly understood and broadly debated. A recent experiment has found strong evidence of the possible role of TMAO in stabilizing lipid membranes. Using the molecular dynamics (MD) simulation technique, we have demonstrated the effect of TMAO on two saturated fully hydrated lipid membranes in their fluid and gel phases. We have captured the impact of TMAO's concentration on the membrane's structural properties along with the fluid/gel phase transition temperatures. On increasing the concentration of TMAO, we see a substantial increase in the packing density of the membrane (estimated by area, thickness, and volume) and enhancement in the orientational order of lipid molecules. Having repulsive interaction with the lipid head group, the TMAO molecules are expelled away from the membrane surface, which induces dehydration of the lipid head groups, increasing the packing density. The addition of TMAO also increases the fluid/gel phase transition temperature of the membrane. All of these results are in close agreement with the experimental observations. This study, therefore, provides a molecular-level understanding of how TMAO can influence the cell membrane of deep-sea organisms and help in combating the osmotic stress condition." @default.
• W3124190639 created "2021-02-01" @default.
• W3124190639 creator A5053997137 @default.
• W3124190639 creator A5080817906 @default.
• W3124190639 date "2021-01-22" @default.
• W3124190639 modified "2023-09-26" @default.
• W3124190639 title "Effect of TMAO on the Structure and Phase Transition of Lipid Membranes: Potential Role of TMAO in Stabilizing Cell Membranes under Osmotic Stress" @default.
• W3124190639 cites W1531578544 @default.
• W3124190639 cites W1563420615 @default.
• W3124190639 cites W1766286537 @default.
• W3124190639 cites W1908353230 @default.
• W3124190639 cites W1949400072 @default.
• W3124190639 cites W1973424040 @default.
• W3124190639 cites W1976499671 @default.
• W3124190639 cites W1980176289 @default.
• W3124190639 cites W1983124595 @default.
• W3124190639 cites W1984434430 @default.
• W3124190639 cites W1985468468 @default.
• W3124190639 cites W1985487126 @default.
• W3124190639 cites W1986477737 @default.
• W3124190639 cites W1992384754 @default.
• W3124190639 cites W1995002044 @default.
• W3124190639 cites W1995773844 @default.
• W3124190639 cites W1999623527 @default.
• W3124190639 cites W2003949305 @default.
• W3124190639 cites W2004177672 @default.
• W3124190639 cites W2005638969 @default.
• W3124190639 cites W2006265229 @default.
• W3124190639 cites W2006708449 @default.
• W3124190639 cites W2006839059 @default.
• W3124190639 cites W2009113911 @default.
• W3124190639 cites W2015917823 @default.
• W3124190639 cites W2022793196 @default.
• W3124190639 cites W2027801804 @default.
• W3124190639 cites W2029168375 @default.
• W3124190639 cites W2029522676 @default.
• W3124190639 cites W2029741562 @default.
• W3124190639 cites W2030885529 @default.
• W3124190639 cites W2035266068 @default.
• W3124190639 cites W2037788435 @default.
• W3124190639 cites W2044307316 @default.
• W3124190639 cites W2046059789 @default.
• W3124190639 cites W2046438851 @default.
• W3124190639 cites W2048623371 @default.
• W3124190639 cites W2049000003 @default.
• W3124190639 cites W2051977718 @default.
• W3124190639 cites W2055003453 @default.
• W3124190639 cites W2055296350 @default.
• W3124190639 cites W2057477511 @default.
• W3124190639 cites W2057653477 @default.
• W3124190639 cites W2059013803 @default.
• W3124190639 cites W2059090244 @default.
• W3124190639 cites W2064275086 @default.
• W3124190639 cites W2065202566 @default.
• W3124190639 cites W2066367620 @default.
• W3124190639 cites W2066414494 @default.
• W3124190639 cites W2071740908 @default.
• W3124190639 cites W2072069399 @default.
• W3124190639 cites W2074717083 @default.
• W3124190639 cites W2076452226 @default.
• W3124190639 cites W2076769060 @default.
• W3124190639 cites W2080042107 @default.
• W3124190639 cites W2080058295 @default.
• W3124190639 cites W2085862980 @default.
• W3124190639 cites W2089038678 @default.
• W3124190639 cites W2090473761 @default.
• W3124190639 cites W2091463270 @default.
• W3124190639 cites W2093806300 @default.
• W3124190639 cites W2094497870 @default.
• W3124190639 cites W2104894769 @default.
• W3124190639 cites W2106704490 @default.
• W3124190639 cites W2109266826 @default.
• W3124190639 cites W2114810075 @default.
• W3124190639 cites W2121682672 @default.
• W3124190639 cites W2128572087 @default.
• W3124190639 cites W2131653836 @default.
• W3124190639 cites W2141711715 @default.
• W3124190639 cites W2142831627 @default.
• W3124190639 cites W2143729332 @default.
• W3124190639 cites W2144909959 @default.
• W3124190639 cites W2145577033 @default.
• W3124190639 cites W2145847261 @default.
• W3124190639 cites W2151929256 @default.
• W3124190639 cites W2157826157 @default.
• W3124190639 cites W2163430576 @default.
• W3124190639 cites W2171268876 @default.
• W3124190639 cites W2295787036 @default.
• W3124190639 cites W2314330043 @default.
• W3124190639 cites W2327524320 @default.
• W3124190639 cites W2332611965 @default.
• W3124190639 cites W2475317853 @default.
• W3124190639 cites W2533606635 @default.
• W3124190639 cites W2561113195 @default.
• W3124190639 cites W2591424651 @default.
• W3124190639 cites W2605887913 @default.
• W3124190639 cites W2734345091 @default.
• W3124190639 cites W2738221053 @default.
• W3124190639 cites W2739266899 @default.

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