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- W3124220305 abstract "Novel peptides containing the sequence -Pro-Leu-Ama(NHOH)- were synthesized and characterized by spectroscopic techniques. Their inhibitory properties towards the activated form of native human gelatinase B (MMP-9) and the catalytic domain of neutrophil collagenase (cdMMP-8) were determined. The most effective inhibitor synthesized exhibits K-i values of 2 x 10(-6) Il I (cdMMP-8) and 5 x 10(-9) RI (MMP-9) thus attaining interesting discrimination between the tested metalloproteinases. A most important feature of this type of inhibitor is its peptide nature making the compounds similar to natural substrates. In spite of the peptide character of the inhibitors synthesized, the P-1-P-1'-peptide bond shows a high resistance to cleavage by the proteinases. (C) 1998 Federation of European Biochemical Societies." @default.
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- W3124220305 date "2010-04-28" @default.
- W3124220305 modified "2023-09-27" @default.
- W3124220305 title "Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases" @default.
- W3124220305 hasPublicationYear "2010" @default.
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