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• W3124235917 abstract "Streptococcus pneumoniae serotype 3 is an important cause of pneumonia, bacteremia, and meningitis.To establish the circulating genotypes of S. pneumoniae serotype 3 isolates recovered from the invasive disease between 1994 to 2015 in Colombia.Of the 365 S. pneumoniae serotype 3 isolates recovered through the laboratory national surveillance program, 117 isolates were analyzed. Pulsed-field gel electrophoresis was used for genotyping, and multilocus sequence typing was determined in representative isolates.The frequency of this serotype increased from 2.7% between 1994 and 1998 to 9.1% between 2011 and 2015 (p=0.000); 91.7% of the isolates showed a genetic similarity greater than 77% and were related to the Netherlands3-31(PMEN31) clone CC180. Several subtypes were identified, two of which showed antimicrobial resistance.In Colombia, the pneumococcal population of the capsular type 3 shows a continuous and homogeneous circulation relating to the clonal group ST-180.Introducción. El serotipo 3 de Streptococcus pneumoniae es una causa importante de neumonía, bacteriemia y meningitis. Objetivo. Establecer los genotipos circulantes de aislamientos del serotipo 3 de S. pneumoniae recuperados de muestras de enfermedad invasiva de 1994 a 2015 en Colombia. Materiales y métodos. Se analizaron 117 de los 365 aislamientos del serotipo 3 de S. pneumoniae recuperados del programa nacional de vigilancia por el laboratorio. El genotipo se estableció con electroforesis en gel de campo pulsado y la tipificación se llevó a cabo mediante secuenciación multilocus en aislamientos representativos. Resultados. La frecuencia de este serotipo aumentó de 2,7 % entre 1994 y 1998 a 9,1 % entre 2011 y 2015 (p=0,000). El 91,7 % de los aislamientos evidenció una similitud genética superior al 77 % y se relacionó con el clon CC180 de Netherlands3-31 (PMEN31). Se identificaron varios subtipos, dos de los cuales mostraron resistencia a los antimicrobianos. Conclusión. En Colombia, la población neumocócica del tipo capsular 3 tiene una circulación continua y homogénea relacionada con el grupo clonal ST-180." @default.
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• W3124235917 date "2021-06-29" @default.
• W3124235917 modified "2023-10-18" @default.
• W3124235917 title "Streptococcus pneumoniae serotype 3 genotypes in invasive isolates from Colombia" @default.
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• W3124235917 doi "https://doi.org/10.7705/biomedica.5407" @default.
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