FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124250402> ?p ?o ?g. }

• W3124250402 abstract "Abstract Genetic factors play a role in the risk of idiopathic pulmonary fibrosis (IPF). Specifically, MUC5B rs35705950 non-risk alleles and immunologic aberrations were associated with the IPF’s progression. However, rare genetic variants have not been systematically investigated in Chinese IPF patients. In this study, we aimed to improve understanding of the genetic architecture of IPF in the Chinese population and to assess whether rare protein-coding variants in the immunity pathway genes are enriched in the IPF patients with non-risk alleles at rs35705950. A case–control exome-wide study including 110 IPF patients and 60 matched healthy controls was conducted. rs35705950 was genotyped by Sanger sequencing. To identify genes enriched in IPF, gene-based association analyses were performed. Identified genes were included for further pathway analyses using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Associations between rs35705950 and genes enriched in the immunity pathway were also tested. 226 genes that were enriched with deleterious variants were identified in IPF patients. Out of them, 36 genes were significantly enriched in GO and KEGG pathways in the IPF. Pathway analyses implicated that these genes were involved in the immune response and cell adhesion. Rare protein-altering variants in genes related to the immunity pathway did not significantly differ between patients with a MUC5B risk allele and individuals without risk allele. We drafted a comprehensive mutational landscape of rare protein-coding variants in the Chinese IPF and identified genes related to immune response and cell adhesion. These results partially explain changes in gene expression involved in the immunity/inflammatory pathways in IPF patients." @default.
• W3124250402 created "2021-02-01" @default.
• W3124250402 creator A5003267973 @default.
• W3124250402 creator A5003457826 @default.
• W3124250402 creator A5004196247 @default.
• W3124250402 creator A5019390272 @default.
• W3124250402 creator A5033560372 @default.
• W3124250402 creator A5052441498 @default.
• W3124250402 creator A5059088556 @default.
• W3124250402 creator A5067703584 @default.
• W3124250402 creator A5090728786 @default.
• W3124250402 date "2021-01-14" @default.
• W3124250402 modified "2023-10-17" @default.
• W3124250402 title "Whole-exome sequencing identifies susceptibility genes and pathways for idiopathic pulmonary fibrosis in the Chinese population" @default.
• W3124250402 cites W1759114984 @default.
• W3124250402 cites W1849849028 @default.
• W3124250402 cites W1938547050 @default.
• W3124250402 cites W1976574577 @default.
• W3124250402 cites W1978134704 @default.
• W3124250402 cites W1982020898 @default.
• W3124250402 cites W1984068087 @default.
• W3124250402 cites W1985846684 @default.
• W3124250402 cites W1987722665 @default.
• W3124250402 cites W1998107112 @default.
• W3124250402 cites W2024722141 @default.
• W3124250402 cites W2031123734 @default.
• W3124250402 cites W2033151532 @default.
• W3124250402 cites W2037645843 @default.
• W3124250402 cites W2041628196 @default.
• W3124250402 cites W2041953582 @default.
• W3124250402 cites W2055245602 @default.
• W3124250402 cites W2073144389 @default.
• W3124250402 cites W2083836105 @default.
• W3124250402 cites W2085498591 @default.
• W3124250402 cites W2087442158 @default.
• W3124250402 cites W2100190218 @default.
• W3124250402 cites W2103168499 @default.
• W3124250402 cites W2107665433 @default.
• W3124250402 cites W2108169091 @default.
• W3124250402 cites W2108234281 @default.
• W3124250402 cites W2108295593 @default.
• W3124250402 cites W2115176808 @default.
• W3124250402 cites W2136493959 @default.
• W3124250402 cites W2142832452 @default.
• W3124250402 cites W2145949861 @default.
• W3124250402 cites W2150044222 @default.
• W3124250402 cites W2150943858 @default.
• W3124250402 cites W2152641884 @default.
• W3124250402 cites W2153305565 @default.
• W3124250402 cites W2153391504 @default.
• W3124250402 cites W2159141436 @default.
• W3124250402 cites W2160906692 @default.
• W3124250402 cites W2163953557 @default.
• W3124250402 cites W2167383172 @default.
• W3124250402 cites W2168133698 @default.
• W3124250402 cites W2168456091 @default.
• W3124250402 cites W2234165587 @default.
• W3124250402 cites W2415132273 @default.
• W3124250402 cites W2419637322 @default.
• W3124250402 cites W2461860734 @default.
• W3124250402 cites W2490184101 @default.
• W3124250402 cites W2543970179 @default.
• W3124250402 cites W2559588208 @default.
• W3124250402 cites W2562105148 @default.
• W3124250402 cites W2581927130 @default.
• W3124250402 cites W2599075603 @default.
• W3124250402 cites W2767079004 @default.
• W3124250402 cites W2807259602 @default.
• W3124250402 cites W2889197569 @default.
• W3124250402 cites W2893461341 @default.
• W3124250402 cites W2902485525 @default.
• W3124250402 cites W2933489383 @default.
• W3124250402 doi "https://doi.org/10.1038/s41598-020-80944-4" @default.
• W3124250402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7809470" @default.
• W3124250402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33446833" @default.
• W3124250402 hasPublicationYear "2021" @default.
• W3124250402 type Work @default.
• W3124250402 sameAs 3124250402 @default.
• W3124250402 citedByCount "7" @default.
• W3124250402 countsByYear W31242504022021 @default.
• W3124250402 countsByYear W31242504022022 @default.
• W3124250402 countsByYear W31242504022023 @default.
• W3124250402 crossrefType "journal-article" @default.
• W3124250402 hasAuthorship W3124250402A5003267973 @default.
• W3124250402 hasAuthorship W3124250402A5003457826 @default.
• W3124250402 hasAuthorship W3124250402A5004196247 @default.
• W3124250402 hasAuthorship W3124250402A5019390272 @default.
• W3124250402 hasAuthorship W3124250402A5033560372 @default.
• W3124250402 hasAuthorship W3124250402A5052441498 @default.
• W3124250402 hasAuthorship W3124250402A5059088556 @default.
• W3124250402 hasAuthorship W3124250402A5067703584 @default.
• W3124250402 hasAuthorship W3124250402A5090728786 @default.
• W3124250402 hasBestOaLocation W31242504021 @default.
• W3124250402 hasConcept C104317684 @default.
• W3124250402 hasConcept C10590036 @default.
• W3124250402 hasConcept C106208931 @default.
• W3124250402 hasConcept C135763542 @default.
• W3124250402 hasConcept C150194340 @default.
• W3124250402 hasConcept C152724338 @default.
• W3124250402 hasConcept C153209595 @default.

• next