Matches in SemOpenAlex for { <https://semopenalex.org/work/W3124293135> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3124293135 abstract "Abstract A population pharmacokinetic (PK) study with 363 subjects was performed using real-world data extracted from electronic heath records (EHRs) to estimate the tacrolimus population PK profile. As population PK studies for oral medications performed using EHR data often assume a regular dosing schedule as prescribed without incorporating exact dosing time, we assessed the sensitivity of the PK parameter estimates to assumptions about dose timing using last-dose times extracted by our own natural language processing system, medExtractR . We also investigated the sensitivity of estimations to absorption rate constants that are often fixed at a published value in tacrolimus population PK analysis. There was no appreciable difference in parameters estimates with vs . without last-dose time incorporated in the data and our sensitivity analysis revealed little difference between parameters estimated assuming a range of absorption rate constants. We also conducted simulation studies to investigate how drug PK profiles and experimental designs such as concentration measurements affects sensitivity to incorrect assumptions about dose timing and absorption rates. Our findings suggest that drugs with a slower elimination rate (or a longer half-life) are less sensitive to dose timing errors and that experimental designs which only allow for trough blood concentrations are usually insensitive to deviation in absorption rate." @default.
- W3124293135 created "2021-02-01" @default.
- W3124293135 creator A5016858483 @default.
- W3124293135 creator A5036726449 @default.
- W3124293135 creator A5055852387 @default.
- W3124293135 creator A5086273557 @default.
- W3124293135 date "2021-01-20" @default.
- W3124293135 modified "2023-09-23" @default.
- W3124293135 title "Sensitivity of Estimated Tacrolimus Population Pharmacokinetic Profile to Inaccurate Assumptions about Dose Timing and Absorption: An Investigation in Real-World and Simulated Data" @default.
- W3124293135 cites W1484895848 @default.
- W3124293135 cites W1517340523 @default.
- W3124293135 cites W1533452775 @default.
- W3124293135 cites W163126517 @default.
- W3124293135 cites W1972287977 @default.
- W3124293135 cites W1983165519 @default.
- W3124293135 cites W2013296110 @default.
- W3124293135 cites W2025752875 @default.
- W3124293135 cites W2026360416 @default.
- W3124293135 cites W2038428490 @default.
- W3124293135 cites W2068650301 @default.
- W3124293135 cites W2087499594 @default.
- W3124293135 cites W2087775788 @default.
- W3124293135 cites W2145434855 @default.
- W3124293135 cites W2166801934 @default.
- W3124293135 cites W2321311842 @default.
- W3124293135 cites W2402766332 @default.
- W3124293135 cites W2929863656 @default.
- W3124293135 cites W2942673049 @default.
- W3124293135 cites W2973894283 @default.
- W3124293135 cites W3000571281 @default.
- W3124293135 cites W3000657409 @default.
- W3124293135 doi "https://doi.org/10.1101/2021.01.15.21249900" @default.
- W3124293135 hasPublicationYear "2021" @default.
- W3124293135 type Work @default.
- W3124293135 sameAs 3124293135 @default.
- W3124293135 citedByCount "0" @default.
- W3124293135 crossrefType "posted-content" @default.
- W3124293135 hasAuthorship W3124293135A5016858483 @default.
- W3124293135 hasAuthorship W3124293135A5036726449 @default.
- W3124293135 hasAuthorship W3124293135A5055852387 @default.
- W3124293135 hasAuthorship W3124293135A5086273557 @default.
- W3124293135 hasBestOaLocation W31242931351 @default.
- W3124293135 hasConcept C105795698 @default.
- W3124293135 hasConcept C112705442 @default.
- W3124293135 hasConcept C125287762 @default.
- W3124293135 hasConcept C127413603 @default.
- W3124293135 hasConcept C159985019 @default.
- W3124293135 hasConcept C192562407 @default.
- W3124293135 hasConcept C21200559 @default.
- W3124293135 hasConcept C24326235 @default.
- W3124293135 hasConcept C2777288759 @default.
- W3124293135 hasConcept C2908647359 @default.
- W3124293135 hasConcept C33923547 @default.
- W3124293135 hasConcept C71924100 @default.
- W3124293135 hasConcept C98274493 @default.
- W3124293135 hasConcept C99454951 @default.
- W3124293135 hasConceptScore W3124293135C105795698 @default.
- W3124293135 hasConceptScore W3124293135C112705442 @default.
- W3124293135 hasConceptScore W3124293135C125287762 @default.
- W3124293135 hasConceptScore W3124293135C127413603 @default.
- W3124293135 hasConceptScore W3124293135C159985019 @default.
- W3124293135 hasConceptScore W3124293135C192562407 @default.
- W3124293135 hasConceptScore W3124293135C21200559 @default.
- W3124293135 hasConceptScore W3124293135C24326235 @default.
- W3124293135 hasConceptScore W3124293135C2777288759 @default.
- W3124293135 hasConceptScore W3124293135C2908647359 @default.
- W3124293135 hasConceptScore W3124293135C33923547 @default.
- W3124293135 hasConceptScore W3124293135C71924100 @default.
- W3124293135 hasConceptScore W3124293135C98274493 @default.
- W3124293135 hasConceptScore W3124293135C99454951 @default.
- W3124293135 hasLocation W31242931351 @default.
- W3124293135 hasOpenAccess W3124293135 @default.
- W3124293135 hasPrimaryLocation W31242931351 @default.
- W3124293135 hasRelatedWork W1964391114 @default.
- W3124293135 hasRelatedWork W1990335353 @default.
- W3124293135 hasRelatedWork W2065005216 @default.
- W3124293135 hasRelatedWork W2089699421 @default.
- W3124293135 hasRelatedWork W2098089006 @default.
- W3124293135 hasRelatedWork W2154372624 @default.
- W3124293135 hasRelatedWork W2317533048 @default.
- W3124293135 hasRelatedWork W2361014804 @default.
- W3124293135 hasRelatedWork W2377624422 @default.
- W3124293135 hasRelatedWork W2802097422 @default.
- W3124293135 isParatext "false" @default.
- W3124293135 isRetracted "false" @default.
- W3124293135 magId "3124293135" @default.
- W3124293135 workType "article" @default.