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• W3124304835 abstract "Abstract Understanding exposures to low doses of ionizing radiation are relevant since most environmental, diagnostic radiology and occupational exposures lie in this region. However, the molecular mechanisms that drive cellular responses at these doses, and the subsequent health outcomes, remain unclear. A local monazite-rich high level natural radiation area (HLNRA) in the state of Kerala on the south-west coast of Indian subcontinent show radiation doses extending from ≤ 1 to ≥ 45 mGy/y and thus, serve as a model resource to understand low dose mechanisms directly on healthy humans. We performed quantitative discovery proteomics based on multiplexed isobaric tags (iTRAQ) coupled with LC–MS/MS on human peripheral blood mononuclear cells from HLNRA individuals. Several proteins involved in diverse biological processes such as DNA repair, RNA processing, chromatin modifications and cytoskeletal organization showed distinct expression in HLNRA individuals, suggestive of both recovery and adaptation to low dose radiation. In protein–protein interaction (PPI) networks, YWHAZ (14-3-3ζ) emerged as the top-most hub protein that may direct phosphorylation driven pro-survival cellular processes against radiation stress. PPI networks also identified an integral role for the cytoskeletal protein ACTB, signaling protein PRKACA; and the molecular chaperone HSPA8. The data will allow better integration of radiation biology and epidemiology for risk assessment [Data are available via ProteomeXchange with identifier PXD022380]." @default.
• W3124304835 created "2021-02-01" @default.
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• W3124304835 date "2021-01-19" @default.
• W3124304835 modified "2023-09-25" @default.
• W3124304835 title "Chronic exposure of humans to high level natural background radiation leads to robust expression of protective stress response proteins" @default.
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• W3124304835 cites W1974343556 @default.
• W3124304835 cites W1978595257 @default.
• W3124304835 cites W1988652724 @default.
• W3124304835 cites W1992981136 @default.
• W3124304835 cites W1993591356 @default.
• W3124304835 cites W2007263630 @default.
• W3124304835 cites W2008676852 @default.
• W3124304835 cites W2009339798 @default.
• W3124304835 cites W2013853442 @default.
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• W3124304835 cites W2041393910 @default.
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• W3124304835 cites W2169522687 @default.
• W3124304835 cites W2192682263 @default.
• W3124304835 cites W2201691085 @default.
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• W3124304835 doi "https://doi.org/10.1038/s41598-020-80405-y" @default.
• W3124304835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7815775" @default.
• W3124304835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33469066" @default.
• W3124304835 hasPublicationYear "2021" @default.
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